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01-04-2009 | Original Paper

Anti-inflammatory and analgesic components from “hierba santa,” a traditional medicine in Peru

Authors: Marii Kawano, Mayumi Otsuka, Kazuhiro Umeyama, Mikio Yamazaki, Tetsuo Shiota, Motoyoshi Satake, Emi Okuyama

Published in: Journal of Natural Medicines | Issue 2/2009

Abstract

“Hierba santa,” a Peruvian herbal medicine, is used to alleviate many symptoms, including headache, hemorrhoids, fever, and rheumatism. Several Cestrum species are said to be the origin of hierba santa. Three lots of hierba santa: Cestrum auriculatum (herb 1 and herb 2) and C. hediundinum (herb 3), which were purchased from Peruvian markets at Cuzco (Andes area) and Equitos (Amazon area), respectively, were examined for their pharmacological activities and active components. Herbs 1–3 showed anti-inflammatory and analgesic activities in the in vivo writhing inhibition test in mouse and inhibited prostaglandin E₁-, E₂-, or ACh-induced contractions of guinea pig ileum in the Magnus method. Activity-based separation of each extract yielded cestrumines A and B, cestrusides A and B, a mixture of (+)- and (−)-pinoresinol glucosides, nicotiflorin, rutin, sinapoyl glucose, ursolic acid, β-sitosteryl glucoside, and 2-sec-butyl-4,6-dihydroxyphenyl-β-d-glucopyranoside. Among them, cestrumine A and cestrusides A and B are new compounds. All three lots of hierba santa do not contain exactly the same active components.

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Title: Anti-inflammatory and analgesic components from “hierba santa,” a traditional medicine in Peru
Authors: Marii Kawano
Mayumi Otsuka
Kazuhiro Umeyama
Mikio Yamazaki
Tetsuo Shiota
Motoyoshi Satake
Emi Okuyama
Publication date: 01-04-2009
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2009
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-008-0302-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anti-inflammatory and analgesic components from “hierba santa,” a traditional medicine in Peru

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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