Top

Published in:

01-10-2017

Anti-coagulant activity of plants: mini review

Authors: Muhammad Akram, Abid Rashid

Published in: Journal of Thrombosis and Thrombolysis | Issue 3/2017

Abstract

Medicinal plants have been used for treatment of human ailments since ancient times. Objective of this study is to document the effect of herbal drugs on anticoagulant therapy. The material for this review was taken mostly from PubMed and the Cochrane database of systematic reviews. Some other relevant references were collected from personal database of papers on anti-coagulant properties of plants. Literature review shows that many plants such as Thymus vulgaris, Cyamopsis tetragonoloba taub, Pulmonaria officinalis and Cinnamomum cassia etc have anti-coagulant activity. This review shows that medicinal plants should be prescribed with care to patients on anticoagulant therapy.

Wells P, Holbrook A, Crowther N (1994) Interactions of warfarin with drugs and food. Ann Intern Med 121:676–683CrossRefPubMed

Miller L (1998) Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 158:2200–2211CrossRefPubMed

Ulubelen A, Guner H, Cetindag M (1988) Alkaloids and coumarins from the roots of Ruta chalepensis var. latifolia. Planta Med 54:551–552CrossRefPubMed

Izzo A (2012) Interactions between herbs and conventional drugs: overview of the clinical data. Med Princ Prac 21:404–428CrossRef

Mestechkina M, Shcherbukhin D, Bannikova E (2008) Anticoagulant activity of low-molecular-weight sulfated derivatives of galactomannan from Cyamopsis tetragonoloba (L.) seeds. Prikl Biokhim Mikrobiol 44:111–116PubMed

Byshevskii S, Gerbert A, Dement’eva P (1990) Nature, properties and the mechanism of the effect on blood coagulation of the preparation obtained from Pulmonaria officinalis. Gematol Transfuziol 35:6–9PubMed

Kim Y, Koo K, Koo Y (2010) Platelet anti-aggregation activities of compounds from Cinnamomum cassia. J Med Food 13:1069–1074CrossRefPubMed

Gadi D, Bnouham M, Aziz M (2009) Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol 125(1):170–174CrossRefPubMed

Naqash SY, Nazeer RA (2011) Anticoagulant, antiherpetic and antibacterial activities of sulphated polysaccharide from Indian medicinal plant Tridax procumbens L. (Asteraceae). Appl. Biochem. Biotechnol 165(3–4):902–912CrossRefPubMed

10.

Kudriashov A, Liapina A, Azieva D (1990) The content of a heparin-like anticoagulant in the flowers of Filipendula ulmaria. Farmakol Toksikol 53(4):39–41PubMed

11.

Liapina A, Kondashevskaia V, Ziadetdinova A (2000) Comparative study of anticoagulants obtained from various extracts of Paeonia anomala. Russ Chem Bull Biol 3:345–349

12.

Lamnaouer D (1999) Anticoagulant activity of coumarins from Ferula communis L.. Therapie 54(6):747–751PubMed

13.

Lau A, Toh D, Chua T (2009) Antiplatelet and anticoagulant effects of Panax notoginseng: comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium. J Ethnopharmacol 125(3):380–386CrossRefPubMed

14.

Ge B, Zhang Z, Zuo Z (2014) Updates on the clinical evidenced herb-warfarin interactions. Evid Based Complement Alternat Med 9:1–18

15.

Okazaki K, Kawazoe K, Takaishi Y (2000) Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). Phytother Res 16:398–399CrossRef

16.

Bone K (2008) Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence? Mol Nutr Food Res 52(7):764–771CrossRefPubMed

17.

Samuels N (2005) Herbal remedies and anticoagulant therapy. Thromb Haemost 93:3–7PubMed

18.

Chan T (2001) Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 35(4):501–504CrossRefPubMed

19.

Anil P, Manish S, Garvendra S, Vijay B (2011) Feverfew (Tanacetum parthenium L.): a systematic review. Pharmacogn Rev 5(9):103–110CrossRef

20.

Rose K, Croissant P, Parliament C (1990) Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report. Neurosurgery 26:880–882CrossRefPubMed

21.

Backon J (1986) Ginger: inhibition of thromboxane synthetase and stimulation of prostacyclin: relevance for medicine and psychiatry. Med Hypotheses 20:271–278CrossRefPubMed

22.

Brendler T, Gruenwald J, Ulbricht C, Basch E (2006) Devil’s Claw (Harpagophytum procumbens DC) an evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother 6(1):89–126PubMed

23.

Lo A, Chan K, Yeung J (1995) Danggui (Angelica sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits. Eur J Drug Metab Pharmacokinet 20(1):55–60CrossRefPubMed

24.

Taylor J, Wilt V (1999) Probable antagonism of warfarin by green tea. Ann Pharmacother 33:426–428CrossRefPubMed

25.

Varadharajan S, Josey C, Kuppusamy A, Muthuswamy U, Thirumalaisamy A, Mugham S, Jagannath P (2010) Anticoagulant activity of methanolic extract of Careya arborea Roxb bark. Int J Pharm Sci Bio 1(2):93–95

26.

Chan K, Yin M, Chao W (2007) Effect of dial-lyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. Food Chem Toxicol 45:502–507CrossRefPubMed

27.

Hamid M, Manicam C, Abdullah JO, Tohit ERM, Seman Z, Chin S (2010) In vitro anticoagulant activities of Melastoma malabathricum Linn. Aqueous leaf extract: a preliminary novel finding. J Med Plants Res 4:1464–1472

28.

Kee N, Mnonopi N, Davids H, Naudé R, Carminita L (2008) Antithrombotic/anticoagulant and anticancer activities of selected medicinal plants from South Africa. Afr J Biotechnol 7(3):217–223

29.

Oliveira C, Maiorano VA, Marcussi S, Sant’ana C, Januário A, Lourenço M, Sampaio S, França S, Pereira P, Soares A (2005) Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms. J Ethanopharmacol 98(2):213–216CrossRef

30.

Osoniyi O, Onajobi F (2003) Coagulant and anticoagulant activities in Jatropha curcas latex. J Ethnopharmacol 89(1):101–105CrossRefPubMed

31.

Yoon S, Pereira M, Pavão M, Hwang J, Pyun Y, Mourão P (2002) The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor II. Thromb Res 106(1):51–58CrossRefPubMed

32.

O’Hara M, Kiefer D, Farrell K, Kemper K (1998) A review of 12 commonly used medicinal herbs. Arch Fam Med 7(6):523–536CrossRefPubMed

33.

Afonne O, Orisakwe O, Obi E, Orish C, Akumka D (2000) Some pharmacological properties of Synclisia scabrida III. Ind J Pharmacol 32:239–241

34.

Matsubara K (2004) Recent advances in marine algal anticoagulants. Curr Med Chem Cardiovasc Hematol Agents 2(1):13–19CrossRefPubMed

35.

Bordia T, Mohammed N, Thomson M, Ali M (1996) An evaluation of garlic and onion as antithrombotic agents. Prostaglandins Leukot Essent Fatty Acids 54(3):183–186CrossRefPubMed

36.

Lee S, Moon J, Chung J, Cha Y, Shin M (2013) Effect of quercetin-rich onion peel extracts on arterial thrombosis in rats. Food Chem Toxicol 57:99–105CrossRefPubMed

37.

Davison C, Levendal R, Frost C (2012) Cardiovascular benefits of an organic extract of Tulbaghia violacea: its anticoagulant and anti-platelet properties. J Med Plants Res 6(33):4815–4824

38.

Kim D, Ku S, Bae J (2012) Anticoagulant activities of curcumin and its derivative. BMB Rep 45(4):221–226CrossRefPubMed

39.

Ansari V, Siddiqui H, Singh S (2012) Antithrombotic and thrombolytic activity of Terminalia belerica fruit extracts. Res J Pharma Bio Chem Sci 3(2):471–478

40.

Quick A (1966) Coagulation. Hemorrhagic diseases and thrombosis. Lea and Febiger, Philadelphia, pp 460–464

Title: Anti-coagulant activity of plants: mini review
Authors: Muhammad Akram
Abid Rashid
Publication date: 01-10-2017
Publisher: Springer US
Published in: Journal of Thrombosis and Thrombolysis / Issue 3/2017
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-017-1546-5

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Anti-coagulant activity of plants: mini review

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2017

Involvement of superoxide generated by NADPH oxidase in the shedding of procoagulant vesicles from human monocytic cells exposed to bupivacaine

Association between aspirin use and deep venous thrombosis in mechanically ventilated ICU patients

Venous thromboembolism prophylaxis for ambulatory cancer patients, can we do better?

Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations

The effective systematic heparin pre-treatment on thrombus formation on pulmonary artery catheter tips during pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a randomized, double-blind study

Comorbidity assessment as predictor of short and long-term mortality in elderly patients with hemodynamically stable acute pulmonary embolism

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page