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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2017

Open Access 01-12-2017 | Letter

Anti-citrullinated protein antibodies and bone loss in patients with early arthritis: comment on the article “Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis” by Bugatti et al.

Authors: Santos Castañeda, Irene Llorente, Rosario García-Vicuña, Isidoro González-Álvaro

Published in: Arthritis Research & Therapy | Issue 1/2017

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Excerpt

We read with great interest the article about the relationship between anti-citrullinated protein antibodies (ACPA), rheumatoid factor (RF) and systemic bone loss in 155 patients with early untreated rheumatoid arthritis (RA), published recently in Arthritis Research & Therapy [1]. The work is really interesting since it shows the association of ACPA with low bone mass in both lumbar spine and total hip in patients with early RA [1]. These findings are supported by recent investigations demonstrating the expression of citrullinated antigens on the surface of osteoclastic linage cells, which converts these cells into prime targets for circulating ACPA [2, 3]. …
Literature
1.
Bugatti S, Bogliolo L, Vitolo B, Manzo A, Montecucco C, Caporali R. Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis. Arthritis Res Ther. 2016;18:226.CrossRefPubMedPubMedCentral
2.
Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012;122:1791–802.CrossRefPubMedPubMedCentral
3.
Malmström V, Catrina AI, Klareskog L. The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. Nat Rev Immunol. 2017;17:60–75.CrossRefPubMed
4.
Llorente I, Merino L, Ortiz AM, Escolano E, González-Ortega S, García-Vicuña R, et al. Anti-citrullinated protein antibodies are associated with decreased bone mineral density: baseline data from a register of early arthritis patients. Rheumatol Int. 2017;37:799-806. doi:10.​1007/​s00296-017-3674-9 [Epub ahead of print].
5.
Orsolini G, Caimmi C, Viapiana O, Idolazzi L, Fracassi E, Gatti D, et al. Titer-dependent effect of anti-citrullinated protein antibodies on systemic bone mass in rheumatoid arthritis patients. Calcif Tissue Int. 2017;101:17-23. doi:10.​1007/​s00223-017-0253-8 [Epub ahead of print].
6.
Bugatti S, Bogliolo L, Montecucco C, Manzo A. B cell autoimmunity and bone damage in rheumatoid arthritis. Reumatismo. 2016;68:117–25.CrossRefPubMed
7.
Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anti citrullinated protein antibodies. Ann Rheum Dis. 2014;73:854–60.CrossRefPubMed
Metadata
Title
Anti-citrullinated protein antibodies and bone loss in patients with early arthritis: comment on the article “Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis” by Bugatti et al.
Authors
Santos Castañeda
Irene Llorente
Rosario García-Vicuña
Isidoro González-Álvaro
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2017
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-017-1362-5

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