Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2016

Open Access 01-12-2016 | Review

Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

Authors: Mehdi Mirsaeidi, Sanaz Gidfar, Ann Vu, Dean Schraufnagel

Published in: Journal of Translational Medicine | Issue 1/2016

Login to get access

Abstract

Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).
Literature
1.
Creutz CE, Pazoles CJ, Pollard HB. Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules. J Biol Chem. 1978;253:2858–66.PubMed
2.
Salzer U, Hinterdorfer P, Hunger U, Borken C, Prohaska R. Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin. Blood. 2002;99:2569–77.CrossRefPubMed
3.
Geisow MJ, Walker JH, Boustead C, Taylor W. Annexins–new family of Ca2+-regulated-phospholipid binding protein. Biosci Rep. 1987;7:289–98.CrossRefPubMed
4.
Sen N, Spitzer AR, Chander A. Calcium-dependence of synexin binding may determine aggregation and fusion of lamellar bodies. Biochem J. 1997;322(Pt 1):103–9.CrossRefPubMedPubMedCentral
5.
6.
7.
8.
Postlethwait JH, Woods IG, Ngo-Hazelett P, Yan YL, Kelly PD, Chu F, Huang H, Hill-Force A, Talbot WS. Zebrafish comparative genomics and the origins of vertebrate chromosomes. Genome Res. 2000;10:1890–902.CrossRefPubMed
9.
10.
Bandorowicz-Pikula J. Annexins: biological importance and annexin-related pathologies. New York: Kluwer Academic/Plenum; 2003. p. 182–95.
11.
Farnaes L, Ditzel HJ. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. J Biol Chem. 2003;278:33120–6.CrossRefPubMed
12.
http://biogpsorg/#goto=genereport&id=311. Accessed 20 Aug 2015.
13.
Kramer PR, Wray S. 17-Beta-estradiol regulates expression of genes that function in macrophage activation and cholesterol homeostasis. J Steroid Biochem Mol Biol. 2002;81:203–16.CrossRefPubMed
14.
Sjolin C, Dahlgren C. Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI. Blood. 1996;87:4817–23.PubMed
15.
Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schurmann M, Muller-Quernheim J, Krawczak M, Rosenstiel P, Schreiber S. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 2008;40:1103–6.CrossRefPubMed
16.
Tomas A, Moss SE. Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope. J Biol Chem. 2003;278:20210–6.CrossRefPubMed
17.
Eberhard DA, Karns LR, VandenBerg SR, Creutz CE. Control of the nuclear-cytoplasmic partitioning of annexin II by a nuclear export signal and by p11 binding. J Cell Sci. 2001;114:3155–66.PubMed
18.
Barton GJ, Newman RH, Freemont PS, Crumpton MJ. Amino acid sequence analysis of the annexin super-gene family of proteins. Eur J Biochem. 1991;198:749–60.CrossRefPubMed
19.
Draeger A, Monastyrskaya K, Babiychuk EB. Plasma membrane repair and cellular damage control: the annexin survival kit. Biochem Pharmacol. 2011;81:703–12.CrossRefPubMed
20.
Rintala-Dempsey AC, Rezvanpour A, Shaw GS. S100-annexin complexes–structural insights. FEBS J. 2008;275:4956–66.CrossRefPubMed
21.
22.
Vahrmann A, Saric M, Koebsch I, Scholze H. alpha14-Giardin (annexin E1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella. Parasitol Res. 2008;102:321–6.CrossRefPubMed
23.
Braun EL, Kang S, Nelson MA, Natvig DO. Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution. J Mol Evol. 1998;47:531–43.CrossRefPubMed
24.
Konopka-Postupolska D, Clark G, Hofmann A. Structure, function and membrane interactions of plant annexins: an update. Plant Sci. 2011;181:230–41.CrossRefPubMed
25.
Odenwald WF, Morris SJ. Identification of a second synexin-like adrenal medullary and liver protein that enhances calcium-induced membrane aggregation. Biochem Biophys Res Commun. 1983;112:147–54.CrossRefPubMed
26.
Tokumitsu H, Mizutani A, Minami H, Kobayashi R, Hidaka H. A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family. J Biol Chem. 1992;267:8919–24.PubMed
27.
Tokumitsu H, Mizutani A, Muramatsu M, Yokota T, Arai K, Hidaka H. Molecular cloning of rabbit CAP-50, a calcyclin-associated annexin protein. Biochem Biophys Res Commun. 1992;186:1227–35.CrossRefPubMed
28.
Lecona E, Turnay J, Olmo N, Guzman-Aranguez A, Morgan RO, Fernandez MP, Lizarbe MA. Structural and functional characterization of recombinant mouse annexin A11: influence of calcium binding. Biochem J. 2003;373:437–49.CrossRefPubMedPubMedCentral
29.
Bances P, Fernandez MR, Rodriguez-Garcia MI, Morgan RO, Fernandez MP. Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. Genomics. 2000;69:95–103.CrossRefPubMed
30.
Solito E, Nuti S, Parente L. Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells. Br J Pharmacol. 1994;112:347–8.CrossRefPubMedPubMedCentral
31.
Brownstein C, Falcone DJ, Jacovina A, Hajjar KA. A mediator of cell surface-specific plasmin generation. Ann N Y Acad Sci. 2001;947:143–55.CrossRefPubMed
32.
Tomas A, Futter C, Moss SE. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. J Cell Biol. 2004;165:813–22.CrossRefPubMedPubMedCentral
33.
van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ. Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J. 2003;22:1478–87.CrossRefPubMedPubMedCentral
34.
Borthwick LA, McGaw J, Conner G, Taylor CJ, Gerke V, Mehta A, Robson L, Muimo R. The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function. Mol Biol Cell. 2007;18:3388–97.CrossRefPubMedPubMedCentral
35.
Hannon R, Croxtall JD, Getting SJ, Roviezzo F, Yona S, Paul-Clark MJ, Gavins FN, Perretti M, Morris JF, Buckingham JC, Flower RJ. Aberrant inflammation and resistance to glucocorticoids in annexin 1−/− mouse. FASEB J. 2003;17:253–5.PubMed
36.
Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest. 2004;113:38–48.CrossRefPubMedPubMedCentral
37.
Srivastava M, Atwater I, Glasman M, Leighton X, Goping G, Caohuy H, Miller G, Pichel J, Westphal H, Mears D, et al. Defects in inositol 1,4,5-trisphosphate receptor expression, Ca2+ signaling, and insulin secretion in the anx7(+/−) knockout mouse. Proc Natl Acad Sci U S A. 1999;96:13783–8.CrossRefPubMedPubMedCentral
38.
Herr C, Smyth N, Ullrich S, Yun F, Sasse P, Hescheler J, Fleischmann B, Lasek K, Brixius K, Schwinger RH, et al. Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes. Mol Cell Biol. 2001;21:4119–28.CrossRefPubMedPubMedCentral
39.
Pandey S, Ranjan R, Pandey S, Mishra RM, Seth T, Saxena R. Effect of ANXA2 gene single nucleotide polymorphism (SNP) on the development of osteonecrosis in Indian sickle cell patient: a PCR-RFLP approach. Indian J Exp Biol. 2012;50:455–8.PubMed
40.
Miyamura H, Nishizawa H, Ota S, Suzuki M, Inagaki A, Egusa H, Nishiyama S, Kato T, Pryor-Koishi K, Nakanishi I, et al. Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss. Mol Hum Reprod. 2011;17:447–52.CrossRefPubMed
41.
Rodriguez-Garcia MI, Fernandez JA, Rodriguez A, Fernandez MP, Gutierrez C, Torre-Alonso JC. Annexin V autoantibodies in rheumatoid arthritis. Ann Rheum Dis. 1996;55:895–900.CrossRefPubMedPubMedCentral
42.
Nielsen CT. Circulating microparticles in systemic lupus erythematosus. Dan Med J. 2012;59:B4548.PubMed
43.
44.
45.
Song J, Shih Ie M, Salani R, Chan DW, Zhang Z. Annexin XI is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients. Clin Cancer Res. 2007;13:6842–9.CrossRefPubMed
46.
Huang Y, Jin Y, Yan CH, Yu Y, Bai J, Chen F, Zhao YZ, Fu SB. Involvement of annexin A2 in p53 induced apoptosis in lung cancer. Mol Cell Biochem. 2008;309:117–23.CrossRefPubMed
47.
Cole SP, Pinkoski MJ, Bhardwaj G, Deeley RG. Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line. Br J Cancer. 1992;65:498–502.CrossRefPubMedPubMedCentral
48.
Rong B, Zhao C, Liu H, Ming Z, Cai X, Gao W, Yang S. Elevated serum annexin A1 as potential diagnostic marker for lung cancer: a retrospective case-control study. Am J Transl Res. 2014;6:558–69.PubMedPubMedCentral
49.
Belhocine TZ, Blankenberg FG, Kartachova MS, Stitt LW, Vanderheyden JL, Hoebers FJ, Van de Wiele C. (99m)Tc-annexin A5 quantification of apoptotic tumor response: a systematic review and meta-analysis of clinical imaging trials. Eur J Nucl Med Mol Imag. 2015;42:2083–97.CrossRef
50.
Birnbaum AD, French DD, Mirsaeidi M, Wehrli S. Sarcoidosis in the national veteran population: association of ocular inflammation and mortality. Ophthalmology. 2015;122:934–8.CrossRefPubMed
51.
52.
Au S, Mirsaeidi M, Aronson IK, Sweiss NJ. Adalimumab induced subcutaneous nodular sarcoidosis: a rare side effect of tumor necrosis factor-alpha inhibitor. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31:249–51.PubMedPubMedCentral
53.
Sweiss NJ, Lower EE, Mirsaeidi M, Dudek S, Garcia JG, Perkins D, Finn PW, Baughman RP. Rituximab in the treatment of refractory pulmonary sarcoidosis. Eur Respir J. 2014;43:1525–8.CrossRefPubMedPubMedCentral
54.
Mirsaeidi M, Machado RF, Schraufnagel D, Sweiss NJ, Baughman RP. Racial difference in sarcoidosis mortality in the United States. Chest. 2015;147:438–49.CrossRefPubMedPubMedCentral
55.
Gideon NM, Mannino DM. Sarcoidosis mortality in the United States 1979–1991: an analysis of multiple-cause mortality data. Am J Med. 1996;100:423–7.CrossRefPubMed
56.
Teirstein AT, Morgenthau AS. End-stage pulmonary fibrosis in sarcoidosis. Mt Sinai J Med. 2009;76:30–6.CrossRefPubMed
57.
Nardi A, Brillet PY, Letoumelin P, Girard F, Brauner M, Uzunhan Y, Naccache JM, Valeyre D, Nunes H. Stage IV sarcoidosis: comparison of survival with the general population and causes of death. Eur Respir J. 2011;38:1368–73.CrossRefPubMed
58.
Swigris JJ, Olson AL, Huie TJ, Fernandez-Perez ER, Solomon J, Sprunger D, Brown KK. Sarcoidosis-related mortality in the United States from 1988 to 2007. Am J Respir Crit Care Med. 2011;183:1524–30.CrossRefPubMedPubMedCentral
59.
Regina Fillerova FM, Zurkova M, Kolek V, Petrek M, Kriegova E. Is a functional variant of ANXA11 R230C associated with impaired apoptosis? Eur Respir J. 2012;40:P777.
60.
Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004;23:2838–49.CrossRefPubMed
61.
Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca2+-dependent manner. Biochem Biophys Res Commun. 2002;291:1166–72.CrossRefPubMed
62.
63.
Craig DB, Dombkowski AA. Disulfide by design 2.0: a web-based tool for disulfide engineering in proteins. BMC Bioinform. 2013;14:346.CrossRef
64.
65.
Fischer A, Rybicki BA. Granuloma genes in sarcoidosis: what is new? Curr Opin Pulm Med. 2015;21:510–6.CrossRefPubMed
66.
Feng X, Zang S, Yang Y, Zhao S, Li Y, Gao X, Zhang L. Annexin A11 (ANXA11) gene polymorphisms are associated with sarcoidosis in a Han Chinese population: a case-control study. BMJ Open. 2014;4:e004466.CrossRefPubMedPubMedCentral
67.
Levin AM, Iannuzzi MC, Montgomery CG, Trudeau S, Datta I, McKeigue P, Fischer A, Nebel A, Rybicki BA. Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans. Genes Immun. 2013;14:13–8.CrossRefPubMedPubMedCentral
Metadata
Title
Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis
Authors
Mehdi Mirsaeidi
Sanaz Gidfar
Ann Vu
Dean Schraufnagel
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2016
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-016-0843-7

Other articles of this Issue 1/2016

Journal of Translational Medicine 1/2016 Go to the issue

Research

ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Research

Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients

Research

Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study

Research

Major components of metabolic syndrome and nutritional intakes in different genotype of UCP2 −866G/A gene polymorphisms in patients with NAFLD

Research

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection

Research

Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits