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Published in: AIDS Research and Therapy 1/2009

Open Access 01-12-2009 | Review

Ankle-brachial index in HIV infection

Authors: Julián Olalla, Daniel Salas, Javier de la Torre, Alfonso del Arco, José Luis Prada, Francisco Martos, Emilio Perea-Milla, Javier García-Alegría

Published in: AIDS Research and Therapy | Issue 1/2009

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Abstract

Prognosis for patients with the human immunodeficiency virus (HIV) has improved with the introduction of highly active antiretroviral therapy (HAART). Evidence over recent years suggests that the incidence of cardiovascular disease is increasing in HIV patients. The ankle-brachial index (ABI) is a cheap and easy test that has been validated in the general population. Abnormal ABI values are associated with increased cardiovascular mortality. To date, six series of ABI values in persons with HIV have been published, but none was a prospective study. No agreement exists concerning the risk factors for an abnormal ABI, though its prevalence is clearly higher in these patients than in the general population. Whether this higher prevalence of an abnormal ABI is associated with a higher incidence of vascular events remains to be determined.
Literature
1.
go back to reference Lewden C, Chene G, Morlat P, Raffi F, Dupon M, Dellamonica P, Pellegrin JL, Katlama C, Dabis F, Leport C: HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population. J Acquir Immune Defic Syndr. 2007, 46 (1): 72-77.PubMed Lewden C, Chene G, Morlat P, Raffi F, Dupon M, Dellamonica P, Pellegrin JL, Katlama C, Dabis F, Leport C: HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population. J Acquir Immune Defic Syndr. 2007, 46 (1): 72-77.PubMed
2.
go back to reference Lima VD, Hogg RS, Harrigan PR, Moore D, Yip B, Wood E, Montaner JS: Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS. 2007, 21 (6): 685-692. 10.1097/QAD.0b013e32802ef30cCrossRefPubMed Lima VD, Hogg RS, Harrigan PR, Moore D, Yip B, Wood E, Montaner JS: Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS. 2007, 21 (6): 685-692. 10.1097/QAD.0b013e32802ef30cCrossRefPubMed
3.
go back to reference Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998, 338 (13): 853-860. 10.1056/NEJM199803263381301CrossRefPubMed Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998, 338 (13): 853-860. 10.1056/NEJM199803263381301CrossRefPubMed
4.
go back to reference Friis-Moller N, Sabin CA, Weber R, d'Arminio MA, El Sadr WM, Reiss P, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Law MG, Kirk O, Phillips AN, Lundgren JD: Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med. 2003, 349 (21): 1993-2003. 10.1056/NEJMoa030218CrossRefPubMed Friis-Moller N, Sabin CA, Weber R, d'Arminio MA, El Sadr WM, Reiss P, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Law MG, Kirk O, Phillips AN, Lundgren JD: Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med. 2003, 349 (21): 1993-2003. 10.1056/NEJMoa030218CrossRefPubMed
5.
go back to reference Friis-Moller N, Weber R, Reiss P, Thiebaut R, Kirk O, d'Arminio MA, Pradier C, Morfeldt L, Mateu S, Law M, El Sadr W, De Wit S, Sabin CA, Phillips AN, Lundgren JD: Cardiovascular disease risk factors in HIV patients – association with antiretroviral therapy. Results from the DAD study. AIDS. 2003, 17 (8): 1179-1193. 10.1097/00002030-200305230-00010CrossRefPubMed Friis-Moller N, Weber R, Reiss P, Thiebaut R, Kirk O, d'Arminio MA, Pradier C, Morfeldt L, Mateu S, Law M, El Sadr W, De Wit S, Sabin CA, Phillips AN, Lundgren JD: Cardiovascular disease risk factors in HIV patients – association with antiretroviral therapy. Results from the DAD study. AIDS. 2003, 17 (8): 1179-1193. 10.1097/00002030-200305230-00010CrossRefPubMed
6.
go back to reference Friis-Moller N, Reiss P, Sabin CA, Weber R, Monforte A, El Sadr W, Thiebaut R, De Wit S, Kirk O, Fontas E, Law MG, Phillips A, Lundgren JD: Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007, 356 (17): 1723-1735. 10.1056/NEJMoa062744CrossRefPubMed Friis-Moller N, Reiss P, Sabin CA, Weber R, Monforte A, El Sadr W, Thiebaut R, De Wit S, Kirk O, Fontas E, Law MG, Phillips A, Lundgren JD: Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007, 356 (17): 1723-1735. 10.1056/NEJMoa062744CrossRefPubMed
7.
go back to reference Hsue PY, Lo JC, Franklin A, Bolger AF, Martin JN, Deeks SG, Waters DD: Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation. 2004, 109 (13): 1603-1608. 10.1161/01.CIR.0000124480.32233.8ACrossRefPubMed Hsue PY, Lo JC, Franklin A, Bolger AF, Martin JN, Deeks SG, Waters DD: Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation. 2004, 109 (13): 1603-1608. 10.1161/01.CIR.0000124480.32233.8ACrossRefPubMed
8.
go back to reference Johnsen S, Dolan SE, Fitch KV, Kanter JR, Hemphill LC, Connelly JM, Lees RS, Lee H, Grinspoon S: Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome. J Clin Endocrinol Metab. 2006, 91 (12): 4916-4924. 10.1210/jc.2006-1140PubMedCentralCrossRefPubMed Johnsen S, Dolan SE, Fitch KV, Kanter JR, Hemphill LC, Connelly JM, Lees RS, Lee H, Grinspoon S: Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome. J Clin Endocrinol Metab. 2006, 91 (12): 4916-4924. 10.1210/jc.2006-1140PubMedCentralCrossRefPubMed
9.
go back to reference Bernal E, Masia M, Padilla S, Gutierrez F: High-density lipoprotein cholesterol in HIV-infected patients: evidence for an association with HIV-1 viral load, antiretroviral therapy status, and regimen composition. AIDS Patient Care STDS. 2008, 22 (7): 569-575. 10.1089/apc.2007.0186CrossRefPubMed Bernal E, Masia M, Padilla S, Gutierrez F: High-density lipoprotein cholesterol in HIV-infected patients: evidence for an association with HIV-1 viral load, antiretroviral therapy status, and regimen composition. AIDS Patient Care STDS. 2008, 22 (7): 569-575. 10.1089/apc.2007.0186CrossRefPubMed
10.
go back to reference Kannel WB, Giordano M: Long-term cardiovascular risk with protease inhibitors and management of the dyslipidemia. Am J Cardiol. 2004, 94 (7): 901-906. 10.1016/j.amjcard.2004.06.025CrossRefPubMed Kannel WB, Giordano M: Long-term cardiovascular risk with protease inhibitors and management of the dyslipidemia. Am J Cardiol. 2004, 94 (7): 901-906. 10.1016/j.amjcard.2004.06.025CrossRefPubMed
11.
go back to reference Mulligan K, Grunfeld C, Tai VW, Algren H, Pang M, Chernoff DN, Lo JC, Schambelan M: Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr. 2000, 23 (1): 35-43.CrossRefPubMed Mulligan K, Grunfeld C, Tai VW, Algren H, Pang M, Chernoff DN, Lo JC, Schambelan M: Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr. 2000, 23 (1): 35-43.CrossRefPubMed
12.
go back to reference Murata H, Hruz PW, Mueckler M: The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem. 2000, 275 (27): 20251-20254. 10.1074/jbc.C000228200CrossRefPubMed Murata H, Hruz PW, Mueckler M: The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem. 2000, 275 (27): 20251-20254. 10.1074/jbc.C000228200CrossRefPubMed
13.
go back to reference Hsue P, Wu Y, Schnell A, Ganz P, Hunt P, Hatano H, Martin J, Deeks S: Association of Abacavir and HIV Disease Factors with Endothelial Function in Patients on Long-term Suppressive ART. 16th Conference on Retroviruses and Opportunistic Infections, Montreal 2009. Abstract 723. 2009, Ref Type: Abstract, Hsue P, Wu Y, Schnell A, Ganz P, Hunt P, Hatano H, Martin J, Deeks S: Association of Abacavir and HIV Disease Factors with Endothelial Function in Patients on Long-term Suppressive ART. 16th Conference on Retroviruses and Opportunistic Infections, Montreal 2009. Abstract 723. 2009, Ref Type: Abstract,
14.
go back to reference Lundgren JD, Battegay M, Behrens G, De Wit S, Guaraldi G, Katlama C, Martinez E, Nair D, Powderly WG, Reiss P, Sutinen J, Vigano A: European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV. HIV Med. 2008, 9 (2): 72-81. 10.1111/j.1468-1293.2007.00534.xCrossRefPubMed Lundgren JD, Battegay M, Behrens G, De Wit S, Guaraldi G, Katlama C, Martinez E, Nair D, Powderly WG, Reiss P, Sutinen J, Vigano A: European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV. HIV Med. 2008, 9 (2): 72-81. 10.1111/j.1468-1293.2007.00534.xCrossRefPubMed
15.
go back to reference Lundgren J, Reiss P, Worm SW, Weber R, El Sadr W, De Wit S, Law M, d'Arminio , Monforte A, Pradier C, Sabin CA: Risk of Myocardial Infarction with Exposure to Specific ARV from the PI, NNRTI, and NRTI Drug Classes: The D:A:D Study. 16th Conference on Retroviruses and Opportunistic Infections, Montreal 2009. Abstract 44LB. 2009, Lundgren J, Reiss P, Worm SW, Weber R, El Sadr W, De Wit S, Law M, d'Arminio , Monforte A, Pradier C, Sabin CA: Risk of Myocardial Infarction with Exposure to Specific ARV from the PI, NNRTI, and NRTI Drug Classes: The D:A:D Study. 16th Conference on Retroviruses and Opportunistic Infections, Montreal 2009. Abstract 44LB. 2009,
16.
go back to reference Sabin CA, Worm SW, Weber R, Reiss P, El Sadr W, Dabis F, De Wit S, Law M, d'Arminio , Monforte A, Friis-Moller N, Kirk O, Pradier C, Weller I, Phillips AN, Lundgren JD: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet. 2008, 371 (9622): 1417-1426. 10.1016/S0140-6736(08)60423-7CrossRefPubMed Sabin CA, Worm SW, Weber R, Reiss P, El Sadr W, Dabis F, De Wit S, Law M, d'Arminio , Monforte A, Friis-Moller N, Kirk O, Pradier C, Weller I, Phillips AN, Lundgren JD: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet. 2008, 371 (9622): 1417-1426. 10.1016/S0140-6736(08)60423-7CrossRefPubMed
17.
go back to reference Law MG, Friis-Moller N, El Sadr WM, Weber R, Reiss P, d'Arminio MA, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Kirk O, Sabin CA, Phillips AN, Lundgren JD: The use of the Framingham equation to predict myocardial infarctions in HIV-infected patients: comparison with observed events in the D:A:D Study. HIV Med. 2006, 7 (4): 218-230. 10.1111/j.1468-1293.2006.00362.xCrossRefPubMed Law MG, Friis-Moller N, El Sadr WM, Weber R, Reiss P, d'Arminio MA, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Kirk O, Sabin CA, Phillips AN, Lundgren JD: The use of the Framingham equation to predict myocardial infarctions in HIV-infected patients: comparison with observed events in the D:A:D Study. HIV Med. 2006, 7 (4): 218-230. 10.1111/j.1468-1293.2006.00362.xCrossRefPubMed
18.
go back to reference Weber R, Sabin CA, Friis-Moller N, Reiss P, El Sadr WM, Kirk O, Dabis F, Law MG, Pradier C, De Wit S, Akerlund B, Calvo G, Monforte A, Rickenbach M, Ledergerber B, Phillips AN, Lundgren JD: Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med. 2006, 166 (15): 1632-1641. 10.1001/archinte.166.15.1632CrossRefPubMed Weber R, Sabin CA, Friis-Moller N, Reiss P, El Sadr WM, Kirk O, Dabis F, Law MG, Pradier C, De Wit S, Akerlund B, Calvo G, Monforte A, Rickenbach M, Ledergerber B, Phillips AN, Lundgren JD: Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med. 2006, 166 (15): 1632-1641. 10.1001/archinte.166.15.1632CrossRefPubMed
19.
go back to reference Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WR, Olin JW, Puschett JB, Rosenfield KA, Sacks D, Stanley JC, Taylor LM, White CJ, White J, White RA, Antman EM, Smith SC, Adams CD, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B: ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation. 2006, 113 (11): e463-e654. 10.1161/CIRCULATIONAHA.106.174526CrossRefPubMed Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WR, Olin JW, Puschett JB, Rosenfield KA, Sacks D, Stanley JC, Taylor LM, White CJ, White J, White RA, Antman EM, Smith SC, Adams CD, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B: ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation. 2006, 113 (11): e463-e654. 10.1161/CIRCULATIONAHA.106.174526CrossRefPubMed
20.
go back to reference Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, Wautrecht JC, Kornitzer M, Newman AB, Cushman M, Sutton-Tyrrell K, Fowkes FG, Lee AJ, Price JF, d'Agostino RB, Murabito JM, Norman PE, Jamrozik K, Curb JD, Masaki KH, Rodriguez BL, Dekker JM, Bouter LM, Heine RJ, Nijpels G, Stehouwer CD, : Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008, 300 (2): 197-208. 10.1001/jama.300.2.197CrossRefPubMed Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, Folsom AR, Hirsch AT, Dramaix M, deBacker G, Wautrecht JC, Kornitzer M, Newman AB, Cushman M, Sutton-Tyrrell K, Fowkes FG, Lee AJ, Price JF, d'Agostino RB, Murabito JM, Norman PE, Jamrozik K, Curb JD, Masaki KH, Rodriguez BL, Dekker JM, Bouter LM, Heine RJ, Nijpels G, Stehouwer CD, : Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008, 300 (2): 197-208. 10.1001/jama.300.2.197CrossRefPubMed
21.
go back to reference Baker JD, Dix DE: Variability of Doppler ankle pressures with arterial occlusive disease: an evaluation of ankle index and brachial-ankle pressure gradient. Surgery. 1981, 89 (1): 134-137.PubMed Baker JD, Dix DE: Variability of Doppler ankle pressures with arterial occlusive disease: an evaluation of ankle index and brachial-ankle pressure gradient. Surgery. 1981, 89 (1): 134-137.PubMed
22.
go back to reference Periard D, Cavassini M, Taffe P, Chevalley M, Senn L, Chapuis-Taillard C, de Valliere S, Hayoz D, Tarr PE: High prevalence of peripheral arterial disease in HIV-infected persons. Clin Infect Dis. 2008, 46 (5): 761-767. 10.1086/527564CrossRefPubMed Periard D, Cavassini M, Taffe P, Chevalley M, Senn L, Chapuis-Taillard C, de Valliere S, Hayoz D, Tarr PE: High prevalence of peripheral arterial disease in HIV-infected persons. Clin Infect Dis. 2008, 46 (5): 761-767. 10.1086/527564CrossRefPubMed
23.
go back to reference Palacios R, Alonso I, Hidalgo A, Aguilar I, Sanchez MA, Valdivielso P, Gonzalez-Santos P, Santos J: Peripheral Arterial Disease in HIV Patients Older than 50 Years of Age. AIDS Res Hum Retroviruses. 2008, 24 (8): 1-4. 10.1089/aid.2008.0001CrossRef Palacios R, Alonso I, Hidalgo A, Aguilar I, Sanchez MA, Valdivielso P, Gonzalez-Santos P, Santos J: Peripheral Arterial Disease in HIV Patients Older than 50 Years of Age. AIDS Res Hum Retroviruses. 2008, 24 (8): 1-4. 10.1089/aid.2008.0001CrossRef
24.
go back to reference Bernal E, Masia M, Padilla S, Hernandez I, Gutierrez F: Low prevalence of peripheral arterial disease in HIV-infected patients with multiple cardiovascular risk factors. J Acquir Immune Defic Syndr. 2008, 47 (1): 126-127. 10.1097/QAI.0b013e318157b0b3CrossRefPubMed Bernal E, Masia M, Padilla S, Hernandez I, Gutierrez F: Low prevalence of peripheral arterial disease in HIV-infected patients with multiple cardiovascular risk factors. J Acquir Immune Defic Syndr. 2008, 47 (1): 126-127. 10.1097/QAI.0b013e318157b0b3CrossRefPubMed
25.
go back to reference Sharma A, Holman S, Pitts R, Minkoff HL, Dehovitz JA, Lazar J: Peripheral arterial disease in HIV-infected and uninfected women. HIV Med. 2007, 8 (8): 555-560. 10.1111/j.1468-1293.2007.00509.xCrossRefPubMed Sharma A, Holman S, Pitts R, Minkoff HL, Dehovitz JA, Lazar J: Peripheral arterial disease in HIV-infected and uninfected women. HIV Med. 2007, 8 (8): 555-560. 10.1111/j.1468-1293.2007.00509.xCrossRefPubMed
26.
go back to reference Gutierrez F, Bernal E, Padilla S, Hernandez I, Masia M: Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients. AIDS. 2008, 22 (11): 1369-1371. 10.1097/QAD.0b013e3282f7cb88CrossRefPubMed Gutierrez F, Bernal E, Padilla S, Hernandez I, Masia M: Relationship between ankle-brachial index and carotid intima-media thickness in HIV-infected patients. AIDS. 2008, 22 (11): 1369-1371. 10.1097/QAD.0b013e3282f7cb88CrossRefPubMed
27.
go back to reference Olalla J, Salas D, Del Arco A, De la TJ, Prada J, Machin-Hamalainen S, Garcia-Alegria J: Ankle-branch index and HIV: the role of antiretrovirals. HIV Med. 2009, 10 (1): 1-5. 10.1111/j.1468-1293.2008.00638.xCrossRefPubMed Olalla J, Salas D, Del Arco A, De la TJ, Prada J, Machin-Hamalainen S, Garcia-Alegria J: Ankle-branch index and HIV: the role of antiretrovirals. HIV Med. 2009, 10 (1): 1-5. 10.1111/j.1468-1293.2008.00638.xCrossRefPubMed
28.
go back to reference Murabito JM, Evans JC, Nieto K, Larson MG, Levy D, Wilson PW: Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study. Am Heart J. 2002, 143 (6): 961-965. 10.1067/mhj.2002.122871CrossRefPubMed Murabito JM, Evans JC, Nieto K, Larson MG, Levy D, Wilson PW: Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study. Am Heart J. 2002, 143 (6): 961-965. 10.1067/mhj.2002.122871CrossRefPubMed
29.
go back to reference Zheng ZJ, Rosamond WD, Chambless LE, Nieto FJ, Barnes RW, Hutchinson RG, Tyroler HA, Heiss G: Lower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Prev Med. 2005, 29 (5 Suppl 1): 42-49. 10.1016/j.amepre.2005.07.019CrossRefPubMed Zheng ZJ, Rosamond WD, Chambless LE, Nieto FJ, Barnes RW, Hutchinson RG, Tyroler HA, Heiss G: Lower extremity arterial disease assessed by ankle-brachial index in a middle-aged population of African Americans and whites: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Prev Med. 2005, 29 (5 Suppl 1): 42-49. 10.1016/j.amepre.2005.07.019CrossRefPubMed
30.
go back to reference Francisci D, Giannini S, Baldelli F, Leone M, Belfiori B, Guglielmini G, Malincarne L, Gresele P: HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS. 2009, 23 (5): 589-596.CrossRefPubMed Francisci D, Giannini S, Baldelli F, Leone M, Belfiori B, Guglielmini G, Malincarne L, Gresele P: HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction. AIDS. 2009, 23 (5): 589-596.CrossRefPubMed
31.
go back to reference Grinspoon SK, Grunfeld C, Kotler DP, Currier JS, Lundgren JD, Dube MP, Lipshultz SE, Hsue PY, Squires K, Schambelan M, Wilson PW, Yarasheski KE, Hadigan CM, Stein JH, Eckel RH: State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary. Circulation. 2008, 118 (2): 198-210. 10.1161/CIRCULATIONAHA.107.189622PubMedCentralCrossRefPubMed Grinspoon SK, Grunfeld C, Kotler DP, Currier JS, Lundgren JD, Dube MP, Lipshultz SE, Hsue PY, Squires K, Schambelan M, Wilson PW, Yarasheski KE, Hadigan CM, Stein JH, Eckel RH: State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary. Circulation. 2008, 118 (2): 198-210. 10.1161/CIRCULATIONAHA.107.189622PubMedCentralCrossRefPubMed
32.
go back to reference Triant VA, Lee H, Hadigan C, Grinspoon SK: Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007, 92 (7): 2506-2512. 10.1210/jc.2006-2190PubMedCentralCrossRefPubMed Triant VA, Lee H, Hadigan C, Grinspoon SK: Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007, 92 (7): 2506-2512. 10.1210/jc.2006-2190PubMedCentralCrossRefPubMed
Metadata
Title
Ankle-brachial index in HIV infection
Authors
Julián Olalla
Daniel Salas
Javier de la Torre
Alfonso del Arco
José Luis Prada
Francisco Martos
Emilio Perea-Milla
Javier García-Alegría
Publication date
01-12-2009
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2009
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/1742-6405-6-6

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