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Experimental & Translational Stroke Medicine

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Open Access 01-12-2013 | Review

Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations

Authors: Jessica M Livingston-Thomas, R Andrew Tasker

Published in: Experimental & Translational Stroke Medicine | Issue 1/2013

Abstract

Many survivors of stroke experience arm impairments, which can severely impact their quality of life. Forcing use of the impaired arm appears to improve functional recovery in post-stroke hemiplegic patients, however the mechanisms underlying improved recovery remain unclear. Animal models of post-stroke rehabilitation could prove critical to investigating such mechanisms, however modeling forced use in animals has proven challenging. Potential problems associated with reported experimental models include variability between stroke methods, rehabilitation paradigms, and reported outcome measures. Herein, we provide an overview of commonly used stroke models, including advantages and disadvantages of each with respect to studying rehabilitation. We then review various forced use rehabilitation paradigms, and highlight potential difficulties and translational problems. Lastly, we discuss the variety of functional outcome measures described by experimental researchers. To conclude, we outline ongoing challenges faced by researchers, and the importance of translational communication. Many stroke patients rely critically on rehabilitation of post-stroke impairments, and continued effort toward progression of rehabilitative techniques is warranted to ensure best possible treatment of the devastating effects of stroke.

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Title: Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations
Authors: Jessica M Livingston-Thomas
R Andrew Tasker
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Experimental & Translational Stroke Medicine / Issue 1/2013
Electronic ISSN: 2040-7378
DOI: https://doi.org/10.1186/2040-7378-5-2

At a glance: The STEP trials

Springer Medicine

Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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Other articles of this Issue 1/2013

Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats

Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients – an observational study

Guideline clinical nutrition in patients with stroke

Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke

An experimental protocol for in vivo imaging of neuronal structural plasticity with 2-photon microscopy in mice

Magnesium treatment for neuroprotection in ischemic diseases of the brain