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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2020 | Angiography | Retinal Disorders

Optical coherence tomography angiography findings of type 1 diabetic patients with diabetic retinopathy, in comparison with type 2 patients

Authors: Taewoong Um, Eoi Jong Seo, Yoon Jeon Kim, Young Hee Yoon

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2020

Abstract

Purpose

To compare optical coherence tomography angiography (OCT-A) parameters between type 1 and type 2 diabetic patients with diabetic retinopathy (DR).

Methods

A total of 70 patients with type 1 diabetes and 70 with type 2 diabetes were retrospectively analyzed. DR was graded as no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR (PDR). Using OCT-A, the foveal avascular zone (FAZ) area (mm²) and vascular density (VD) (%) were calculated in the superficial capillary plexus (SCP) and deep capillary plexus (DCP).

Results

In both type 1 and 2 diabetes patients, the FAZ area (mm²) in both capillary plexuses (CP) increased with DR progression, whereas the VD (%) progressively decreased. The changes in the FAZ area and the VD were significantly greater in the DCP than in the SCP in both types of diabetes patients(p < 0.001). In the analysis of decreasing slope of the VD in the DCP, attenuation was not significant until severe NPDR stage but then abruptly decreased when it progressed to PDR stage in type 1 diabetes. In type 2 diabetes, the DCP VD decreased gradually as DR stage progressed.

Conclusions

As DR progression, the increasing in FAZ area and the decreasing in VD are more severe in the DCP than in the SCP in both types of diabetes. In type 1 diabetes eyes, they were remained in relatively healthy until it gets to the advanced stage of DR, while the gradual deterioration of FAZ area and VD was found from the early stage to the advanced stage of DR in type 2 diabetes.

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Title: Optical coherence tomography angiography findings of type 1 diabetic patients with diabetic retinopathy, in comparison with type 2 patients
Authors: Taewoong Um
Eoi Jong Seo
Yoon Jeon Kim
Young Hee Yoon
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Angiography
Diabetic Retinopathy
Diabetic Retinopathy
Type 1 Diabetes
Type 2 Diabetes
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04517-6

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Springer Medicine

Optical coherence tomography angiography findings of type 1 diabetic patients with diabetic retinopathy, in comparison with type 2 patients

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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