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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-11-2020 | Angiography | Retinal Disorders

Evaluation of retinal neurovascular structures by optical coherence tomography and optical coherence tomography angiography in children and adolescents with type 1 diabetes mellitus without clinical sign of diabetic retinopathy

Authors: Semra Tiryaki Demir, Ahmet Ucar, Gizem Kara Elitok, Mehmet Egemen Karatas, Murat Karapapak, Oguz Kaan Kutucu, Saniye Uke Uzun, Dilek Guven

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2020

Abstract

Background

The aim of the study was to investigate whether retinal neurovascular structural impairment in children and adolescents with type 1 diabetes mellitus (T1D) without clinical signs of diabetic retinopathy (DR) could be detected early via optical coherence tomography (OCT) and OCT angiography (OCTA).

Methods

In the current prospective, cross-sectional, observational clinical study children and adolescents with T1D without DR were evaluated between December 2018 and May 2019. Retinal neurovascular structures in the macular and optic disc regions were examined in detail and quantitatively assessed using OCT and OCTA. Data from subjects with T1D were compared with data from healthy controls. Whether retinal neurovascular structural changes were significantly associated with puberty stage, diabetes duration, and HbA1c level was also investigated.

Results

The T1D group included 110 eyes and the control group included 84 eyes. In the T1D group the mean inside disc vessel density (VD) was significantly lower than that of the control group (p < 0.001), as was the mean superior temporal disc VD (p < 0.043). Puberty stage was significantly associated with retinal thickness, parafoveal superficial capillary plexus VD, and peripapillary retinal nerve fiber layer thickness (p < 0.05). Diabetes duration and HbA1c level was significantly correlated with retinal layer thickness, foveal avascular zone diameter, and superficial and deep capillary plexus VDs.

Conclusion

In children and adolescents with T1D without clinical signs of DR, the VD of the disc region is affected earlier than the macular region. In these patients, early neurovascular impairment can be detected non-invasively via OCT and OCTA.

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Title: Evaluation of retinal neurovascular structures by optical coherence tomography and optical coherence tomography angiography in children and adolescents with type 1 diabetes mellitus without clinical sign of diabetic retinopathy
Authors: Semra Tiryaki Demir
Ahmet Ucar
Gizem Kara Elitok
Mehmet Egemen Karatas
Murat Karapapak
Oguz Kaan Kutucu
Saniye Uke Uzun
Dilek Guven
Publication date: 01-11-2020
Publisher: Springer Berlin Heidelberg
Keywords: Angiography
Diabetic Retinopathy
Diabetic Retinopathy
Diabetes
Type 1 Diabetes
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04842-1

At a glance: The STEP trials

Springer Medicine

Evaluation of retinal neurovascular structures by optical coherence tomography and optical coherence tomography angiography in children and adolescents with type 1 diabetes mellitus without clinical sign of diabetic retinopathy

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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