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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-07-2021 | Angiography | Retinal Disorders

Dilated retinal large vessels and capillaries associated with diabetic macular edema and photoreceptor loss respectively

Authors: Jianqin Lei, Xiayu Xu, Li Chen, Xiaojuan Fan, Nizar Saleh Abdelfattah

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2021

Abstract

Purpose

Previously, we measured retinal large vessels and capillaries separately on optical coherence tomography angiography (OCTA). In the present study, we aim to evaluate the role of these parameters in association to diabetic macular edema (DME) and ellipsoid zone disruption (EZD).

Methods

In this cross-sectional study, 54 eyes from 31 patients (10 females, 31 Asians) with severe non-proliferative diabetic retinopathy (25 eyes) or proliferative diabetic retinopathy (PDR, 29 eyes) were enrolled. All eyes underwent 3 × 3 mm OCTA scans centered on the fovea. Perfusion density (PD), vessel length density (VLD), and vessel diameter index (VDI) were calculated for retinal large vessels and superficial capillaries separately. Other OCTA findings included suspended scattering particles in motion (SSPiM), number of microaneurysms (MA) in all retinal layers, and the area of foveal avascular zone (FAZ) of superficial capillary plexus. DME and EZD were evaluated on B-scans. Both univariate and multivariate analysis were performed.

Results

Of the 54 study eyes, 31 (57%) had DME and 21 (40%) had EZD. Multivariate regression model showed that PDR (β = 27.8, 95% confidence interval (CI): 2.7–282.8, p = 0.005), more MA (β = 2.5, 95% CI: 1.3–4.5, p = 0.003), and increased VDI of larger vessels (β = 1.9, 95% CI: 1.0–3.5, p = 0.047) were risk factors for DME. As for EZD, presence of SSPiM (β = 5.5, 95% CI: 1.2–26.1, p = 0.032) and increased VDI of capillaries (β = 3.9, 95% CI: 1.1–13.8, p = 0.034) were risk factors.

Conclusions

In eyes with diabetic retinopathy, dilation of retinal larger vessels was associated with macular edema, while dilation of retinal capillaries was associated with ellipsoid zone disruption.

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Title: Dilated retinal large vessels and capillaries associated with diabetic macular edema and photoreceptor loss respectively
Authors: Jianqin Lei
Xiayu Xu
Li Chen
Xiaojuan Fan
Nizar Saleh Abdelfattah
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Angiography
Diabetic Retinopathy
Edema
Diabetic Retinopathy
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2021
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-05039-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dilated retinal large vessels and capillaries associated with diabetic macular edema and photoreceptor loss respectively

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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