Skip to main content
Top
Published in: BMC Pediatrics 1/2021

Open Access 01-12-2021 | Anemia | Research

Anemia among children living with HIV/AIDS on HAART in Mekelle Hospital, Tigray regional state of northern ethiopia – a cross-sectional study

Authors: Feven Tesfay, Abrha Gebregerges, Haftay Gebrehiwot, Haftu Hailekiros, Letegebriel Girmay, Hadush Bekuretsion, Gebrekidan Gebrezigher, Gebreslassie Gebremariam, Gebreyohannes Teklehaimanot

Published in: BMC Pediatrics | Issue 1/2021

Login to get access

Abstract

Background

Anemia is a common complication of HIV/AIDS in children. There is lack of evidence on anemia prevalence among children living with HIV/AIDS on highly active antiretroviral therapy (HAART) in Tigray regional state, which the current study aimed to generate.

Methods

An institution-based cross-sectional study was conducted on 241 children living with HIV/AIDS on HAART attending the antiretroviral therapy (ART) clinic of Mekelle hospital from November 2018-January 2019. Socio-demographic data were collected using a structured pretested questionnaire. Participants’ hemoglobin level was utilized to determine the prevalence of anemia. WHO cut-off values for Hgb were used to categorise the severity of anemia. Microscopic examination was performed for morphological classification of anemia.

Results

Among the participants, 7 % (n = 16) were anemic in this study. Of these, 56 %, 19 %, and 25 % had mild, moderate, and severe anemia, respectively. Morphologically, normocytic-normochromic anemia was found the most common type of anemia in this study.

Conclusions

The prevalence of anemia among participants was low in this study. However, a considerable proportion of participants had severe anemia, requiring regular monitoring of anemia status in these patients for better clinical outcomes and quality of life improvements.
Literature
3.
go back to reference Pasricha SR. Anemia: a comprehensive global estimate. Blood. 2014;123:611–2.CrossRef Pasricha SR. Anemia: a comprehensive global estimate. Blood. 2014;123:611–2.CrossRef
7.
go back to reference Mocroft A, Kirk O, Barton S. Anemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. AIDS. 1999;13:943–50.CrossRef Mocroft A, Kirk O, Barton S. Anemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. AIDS. 1999;13:943–50.CrossRef
8.
go back to reference Sullivan PS, Hanson DL, Chu SY, Ward JW. Epidemiology of anemia in human immunodeficiency virus (HIV) infected persons: results from multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998;91:301–8.CrossRef Sullivan PS, Hanson DL, Chu SY, Ward JW. Epidemiology of anemia in human immunodeficiency virus (HIV) infected persons: results from multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998;91:301–8.CrossRef
9.
go back to reference Ludwig H, Strasser K. Symptomatology of anemia. Semin Oncol. 2001;28:7–14.CrossRef Ludwig H, Strasser K. Symptomatology of anemia. Semin Oncol. 2001;28:7–14.CrossRef
10.
go back to reference Belperio PS, Rhew DC. Prevalence and outcomes of anaemia in individuals with human immunodefficiency virus: a systemic review of literature. AM J Med. 2004;116:27S-43S.CrossRef Belperio PS, Rhew DC. Prevalence and outcomes of anaemia in individuals with human immunodefficiency virus: a systemic review of literature. AM J Med. 2004;116:27S-43S.CrossRef
11.
go back to reference Brabin JB, Premji Z, Verhoeff F. Iron deficiency anaemia: reexamining the nature and magnitude of the public health problem. J Nutr. 2001;131:636S-48S. Brabin JB, Premji Z, Verhoeff F. Iron deficiency anaemia: reexamining the nature and magnitude of the public health problem. J Nutr. 2001;131:636S-48S.
12.
go back to reference Semba RD. Iron deficiency anemia and the cycle of poverty among human immunodeficiency virus infected women in the inner city. Clin Infect Dis. 2003;37:S105-11.CrossRef Semba RD. Iron deficiency anemia and the cycle of poverty among human immunodeficiency virus infected women in the inner city. Clin Infect Dis. 2003;37:S105-11.CrossRef
14.
go back to reference Calis JC, van Hensbroek MB, de Haan RJ, Moons P, Brabin BJ, Bates I. HIV-associated anemia in children: a systematic review from a global perspective. AIDS. 2008;22:1099.CrossRef Calis JC, van Hensbroek MB, de Haan RJ, Moons P, Brabin BJ, Bates I. HIV-associated anemia in children: a systematic review from a global perspective. AIDS. 2008;22:1099.CrossRef
16.
go back to reference Mulugeta A, Assefa H, Tewelde T, Dube L. Determinants of survival among HIV positive children on antiretroviral therapy in public hospitals, Addis Ababa, Ethiopia. Qual Prim Care. 2017;25:235–241. Mulugeta A, Assefa H, Tewelde T, Dube L. Determinants of survival among HIV positive children on antiretroviral therapy in public hospitals, Addis Ababa, Ethiopia. Qual Prim Care. 2017;25:235–241.
17.
go back to reference Wagnew F, Eshetie S, Alebel A, Tesema C, Kibret GD, Gebrie A, et al. Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2019;19:1032.CrossRef Wagnew F, Eshetie S, Alebel A, Tesema C, Kibret GD, Gebrie A, et al. Burden of anemia and its association with HAART in HIV infected children in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2019;19:1032.CrossRef
18.
go back to reference Engdaw B, Alem M, Melku M, Addis Z, Terefe B, Yitayew G. Prevalence and associated risk factors of anemia among HIV infected children in Gondar university hospital, Northwest Ethiopia. BMC Hematol. 2015;15:12.CrossRef Engdaw B, Alem M, Melku M, Addis Z, Terefe B, Yitayew G. Prevalence and associated risk factors of anemia among HIV infected children in Gondar university hospital, Northwest Ethiopia. BMC Hematol. 2015;15:12.CrossRef
21.
go back to reference Fenta DA, Nuru MM, Yemane T, Asres Y, Wube TB. Anemia and related factors among highly active antiretroviral therapy experienced children in Hawassa comprehensive specialized hospital, southern Ethiopia: emphasis on patient management. Drug Healthc Patient Saf. 2020;12:49–56.CrossRef Fenta DA, Nuru MM, Yemane T, Asres Y, Wube TB. Anemia and related factors among highly active antiretroviral therapy experienced children in Hawassa comprehensive specialized hospital, southern Ethiopia: emphasis on patient management. Drug Healthc Patient Saf. 2020;12:49–56.CrossRef
22.
go back to reference Geletaw T, Tadesse MZ, Demisse AG. Hematologic abnormalities and associated factors among HIV infected children pre- and post-antiretroviral treatment, Northwest Ethiopia. J Blood Med. 2017;8:99–105.CrossRef Geletaw T, Tadesse MZ, Demisse AG. Hematologic abnormalities and associated factors among HIV infected children pre- and post-antiretroviral treatment, Northwest Ethiopia. J Blood Med. 2017;8:99–105.CrossRef
24.
go back to reference Nyesigire Ruhinda E, Bajunirwe F, Kiwanuka J. Anaemia in HIV-infected children: severity, types and effect on response to HAART. BMC Pediatr. 2012;12:170.CrossRef Nyesigire Ruhinda E, Bajunirwe F, Kiwanuka J. Anaemia in HIV-infected children: severity, types and effect on response to HAART. BMC Pediatr. 2012;12:170.CrossRef
25.
go back to reference Muluneh A, Fessahaye A. Hematologic abnormalities among children on HAART in Jimma University specialized hospital, southwestern Ethiopia. Ethiop J Health Sci. 2009;19:83–89. Muluneh A, Fessahaye A. Hematologic abnormalities among children on HAART in Jimma University specialized hospital, southwestern Ethiopia. Ethiop J Health Sci. 2009;19:83–89.
26.
go back to reference Menon MP, Yoon SS. Prevalence and factors associated with anemia among children under 5 years of age—Uganda, 2009. Am J Trop Med Hyg. 2015;93:521–6.CrossRef Menon MP, Yoon SS. Prevalence and factors associated with anemia among children under 5 years of age—Uganda, 2009. Am J Trop Med Hyg. 2015;93:521–6.CrossRef
27.
go back to reference Shetn A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel NM, et al. Anemia and growth failure among HIV-infected children in India: a retrospective analysis. BMC Pediatr. 2009;9:37.CrossRef Shetn A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel NM, et al. Anemia and growth failure among HIV-infected children in India: a retrospective analysis. BMC Pediatr. 2009;9:37.CrossRef
28.
go back to reference Gebremedhin A, Gebremariam S, Haile F, Weldearegawi B, Decotelli C. Predictors of mortality among HIV infected children on anti-retroviral therapy in Mekelle Hospital, Northern Ethiopia: a retrospective cohort study. BMC Public Health. 2013;13:1047.CrossRef Gebremedhin A, Gebremariam S, Haile F, Weldearegawi B, Decotelli C. Predictors of mortality among HIV infected children on anti-retroviral therapy in Mekelle Hospital, Northern Ethiopia: a retrospective cohort study. BMC Public Health. 2013;13:1047.CrossRef
Metadata
Title
Anemia among children living with HIV/AIDS on HAART in Mekelle Hospital, Tigray regional state of northern ethiopia – a cross-sectional study
Authors
Feven Tesfay
Abrha Gebregerges
Haftay Gebrehiwot
Haftu Hailekiros
Letegebriel Girmay
Hadush Bekuretsion
Gebrekidan Gebrezigher
Gebreslassie Gebremariam
Gebreyohannes Teklehaimanot
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-021-02960-1

Other articles of this Issue 1/2021

BMC Pediatrics 1/2021 Go to the issue