Published in:
Open Access
01-12-2010 | Poster presentation
Analysis of transmitted drug resistance, resistance mutations and future antiretroviral efficacy in HIV-1 subtype F infected-patients prior to therapy
Authors:
LSC Manolescu, CM Sultana, C Vagu, A Temereanca, SM Ruta
Published in:
Journal of the International AIDS Society
|
Special Issue 4/2010
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Excerpt
Studies have shown that transmitted drug resistance mutations involving major antiretroviral classes appear to persist for months, even years, after infection. Efficacy of antiretroviral treatment in recently infected individuals imply resistance testing prior to initialize treatment. The prevalence of drug resistance mutations in patients newly infected with HIV-1 is high throughout the world and little is known about transmission of resistant virus in non B subtypes. In Romania from 1992 to 2009, analysis of the relative incidence of different HIV-1 circulating strains revealed a stable profile with high prevalence of subtype - F, in both long term survivors and recently infected adults. …