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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2008

01-03-2008 | Head and Neck Oncology

Analysis of Risk Factors of Predictive Local Tumor Control in Oral Cavity Cancer

Authors: Chun-Ta Liao, MD, Joseph Tung-Chieh Chang, MD, MHA, Hung-Ming Wang, MD, Shu-Hang Ng, MD, Chuen Hsueh, MD, Li-Yu Lee, MD, Chih-Hung Lin, MD, I-How Chen, MD, Shiang-Fu Huang, MD, Ann-Joy Cheng, PhD, Tzu-Chen Yen, MD, PhD

Published in: Annals of Surgical Oncology | Issue 3/2008

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Abstract

Background

Survival in oral cavity squamous cell carcinoma (OSCC) depends heavily on locoregional control. In this study, we sought to determine the independent prognosticators for local tumor control, disease-specific survival (DSS), and overall survival (OS) rates in a series of OSCC patients undergoing radical surgery.

Methods

We retrospectively reviewed 827 consecutive OSCC patients undergoing radical surgery from January 1998 to March 2005. Postoperative radiotherapy was performed in patients with pT4 tumors, positive lymph node(s), or close margins (≤4 mm). Local control rates and survivals were plotted using the Kaplan–Meier method.

Results

On multivariate analysis (MVA), unfavorable prognostic factors for local control were pathological margins ≤7 mm (P < 0.001), pathological tumor depth ≥10 mm (P < 0.001), pathological positive lymph node(s) (P = 0.001), and the presence of betel quid chewing (P = 0.012). The same predictors, with the exception of betel quid chewing and pathological positive lymph node(s), were independently associated with DSS and OS in MVA. A prognostic scoring system was formulated by summing up the four significant local control covariates from MVA. Patients with scores of 3–4 had a significantly poorer local control rate compared to patients with scores of 0–2 (score 3 versus score 0–2: P < 0.001; score 4 versus score 0–2: P < 0.001)

Conclusions

Taken together, our data suggest that pathological margins and pathological tumor depth are major independent prognosticators not only for local tumor control, but also for DSS and OS.
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Metadata
Title
Analysis of Risk Factors of Predictive Local Tumor Control in Oral Cavity Cancer
Authors
Chun-Ta Liao, MD
Joseph Tung-Chieh Chang, MD, MHA
Hung-Ming Wang, MD
Shu-Hang Ng, MD
Chuen Hsueh, MD
Li-Yu Lee, MD
Chih-Hung Lin, MD
I-How Chen, MD
Shiang-Fu Huang, MD
Ann-Joy Cheng, PhD
Tzu-Chen Yen, MD, PhD
Publication date
01-03-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 3/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-007-9761-5

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