Published in:
01-12-2017 | Editorial
Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders
Authors:
Jonathan Gotfried, Ron Schey
Published in:
Digestive Diseases and Sciences
|
Issue 12/2017
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Excerpt
Nausea is an unpleasant sensation typically experienced in the epigastrium or throat, often accompanied by the impending urge to vomit [
1]. While the neural pathways involved with nausea and emesis are generally well defined, the specific pathways involved in the nausea mechanism are not fully elucidated. Within the gastrointestinal tract, mechanical obstruction, organic disorders such as peptic ulcer disease or malignancy, and neuromuscular dysfunction such as chronic intestinal pseudo-obstruction and gastroparesis may all lead to nausea. Medications, chemotherapy, and ingested noxious agents also contribute to the pathogenesis of nausea, mainly through recognition of circulating emetic agents in the blood by central chemoreceptors [
2]. Nausea is an oft-cited adverse effect of medications that often prompts therapy discontinuation. …