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European Radiology
Published in: European Radiology 11/2010

01-11-2010 | Ultrasound

Analysis of intrahepatic vascular morphological changes of chronic liver disease for assessment of liver fibrosis stages by micro-flow imaging with contrast-enhanced ultrasound: preliminary experience

Authors: Katsutoshi Sugimoto, Junji Shiraishi, Fuminori Moriyasu, Shigeki Ichimura, Ryo Metoki, Kunio Doi

Published in: European Radiology | Issue 11/2010

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Abstract

Objective

To assess morphological vascular changes due to an increase in liver fibrosis by using micro-flow imaging (MFI) of contrast-enhanced ultrasound.

Methods

MFI was performed in 47 patients who underwent liver biopsy, and in 10 normal cases. For 27/57 cases, we performed MFI twice in order to assess the reproducibility of the examination, thus yielding a total of 84 examinations. Seven physicians interpreted each case individually by assigning confidence levels for the presence or absence of three imaging features that were related to alteration of portal vein morphology: angle widening, tapering/interruption and tortuosity.

Results

Pearson’s correlation coefficient between the average rating scores based on tortuosity and the histological fibrosis stage was 0.806 (p < 0.001). The diagnostic accuracy of the average area under the ROC curve, which was estimated by use of the confidence levels of tapering/interruption, tortuosity and angle widening, was 0.964 for F1 vs. F2–4, 0.968 for F1–2 vs. F3–4 and 0.910 for F1–3 vs. F4. The average correlation coefficient between the ratings on different images from the same patients was 0.838.

Conclusion

Assessment of morphological intrahepatic vascular changes on MFI may be useful for grading liver fibrosis.
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Literature
1.
Anthony PP, Ishak KG, Nayak NC et al (1978) The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol 31:395–414CrossRefPubMed
2.
Daniel PM, Prichard MML, Reynell PC (1952) The portal circulation in experimental cirrhosis of the liver. J Pathol Bacteriol 114:53–60CrossRef
3.
Popper H, Elias H, Patty DE (1952) Vascular pattern of the cirrhotic liver. Am J Clin Pathol 22:717–729PubMed
4.
Sugimoto K, Moriyasu F, Kamiyama N et al (2008) Analysis of morphological vascular changes of hepatocellular carcinoma by micro flow imaging using contrast-enhanced sonography. Hepatol Res 38:790–799CrossRefPubMed
5.
Shiraishi J, Sugimoto K, Moriyasu F, Kamiyama N, Doi K (2008) Computer-aided diagnosis for the classification of focal liver lesions by use of contrast-enhanced ultrasonography. Med Phys 35:1734–1746CrossRefPubMed
6.
Wilson SR, Jang HJ, Kim TK, Iijima H, Kamiyama N, Burns PN (2008) Real-time temporal maximum-intensity projection imaging of hepatic lesions with contrast-enhanced sonography. AJR Am J Roentgenol 190:691–695CrossRefPubMed
7.
Burns PN (2002) Contrast ultrasound technology. In: Solbital L, Martegani A, Leen E, Correas JM, Burns PN, Becker D (eds) Contrast-enhanced ultrasound of liver diseases. Springer, Milan, pp 1–19
8.
Ichida F, Tsuji T, Omata M et al (1996) New Inuyama classification: new criteria for histological assessment of chronic hepatitis. Int Hepatol Commun 6:112–119CrossRef
9.
Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ (1994) Classification of chronic hepatitis: diagnosis, grading and staining. Hepatology 19:1513–1520CrossRefPubMed
10.
Ludwing J (1993) The nomenclature of chronic active hepatitis; An obituary. Gastroenterology 105:274
11.
MacMahon H, Engelman R, Behlen FM et al (1999) Computer-aided diagnosis of pulmonary nodules: results of a large-scale observer test. Radiology 213:723PubMed
12.
Shrout PE, Fleiss JL (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428CrossRefPubMed
13.
Strader DB, Wright T, Thomas DL, Seeff LB (2004) Diagnosis, management, and treatment of hepatitis C. Hepatology 39:1147–1171CrossRefPubMed
14.
15.
De Franchis R (2005) Evolving consensus in portal hypertension: report of the Baveno IV Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension. J Hepatol 43:167–176CrossRefPubMed
16.
Kelty RH, Baggenstoss AH, Butt HR (1950) The relation of the regenerated liver nodule to the vascular bed in cirrhosis. Gastroenterology 15:285–295PubMed
17.
Wai CT, Greenson JK, Fontana RJ et al (2003) A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with hepatitis C. Hepatology 38:518–526CrossRefPubMed
18.
Imbert-Bismut F, Ratziu V, Pieroni L, Charlotte F, Benhamou Y, Poynard T (2001) Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 357:1069–1075CrossRefPubMed
19.
Rocky DC, Bissel DM (2006) Noninvasive measures of liver fibrosis. Hepatology 43:S113–S120CrossRef
20.
Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209–218PubMed
21.
Colli A, Fraquelli M, Andreoletti M, Marino B, Zuccoli E, Conte D (2003) Severe liver fibrosis or cirrhosis: accuracy of US for detection - analysis of 300 cases. Radiology 227:89–94CrossRefPubMed
22.
Fridrich-Rust M, Ong MF, Herrmann E et al (2007) Real-time elastography for noninvasive assessment of liver fibrosis in chronic viral hepatitis. AJR Am J Roentgenol 188:758–764CrossRef
23.
Aguirre DA, Behling CA, Alpert E, Hassanein TI, Sirlin CB (2006) Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging. Radiology 239:425–437CrossRefPubMed
24.
Annet L, Materne R, Danse E, Jamart J, Horsmans Y, Van Beers BE (2003) Hepatic flow parameters measured with MR imaging and Doppler US: correlation with degree of cirrhosis and portal hypertension. Radiology 229:409–414CrossRefPubMed
25.
Koinuma M, Ohashi I, Hanafusa K, Shibuya H (2005) Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis. J Magn Reson Imaging 22:80–85CrossRefPubMed
26.
Huwart L, Sempoux C, Salameh N et al (2007) Liver fibrosis: noninvasive assessment with MR elastography versus aspirate aminotransferase-to-platelet ratio index. Radiology 245:458–466CrossRefPubMed
27.
Poniachik J, Bernstein DE, Reddy KR et al (1996) The role of laparoscopy in the diagnosis of cirrhosis. Gastrointest Endosc 43:568–571CrossRefPubMed
28.
Pagliaro L, Rinaldi F, Craxi A et al (1983) Percutaneous blind biopsy versus laparoscopy with guided biopsy in diagnosis of cirrhosis: a prospective, randomized trial. Dig Dis Sci 28:39–43CrossRefPubMed
29.
Maharaj B, Maharaj RJ, Leary WP et al (1986) Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet 1:523–525CrossRefPubMed
Metadata
Title
Analysis of intrahepatic vascular morphological changes of chronic liver disease for assessment of liver fibrosis stages by micro-flow imaging with contrast-enhanced ultrasound: preliminary experience
Authors
Katsutoshi Sugimoto
Junji Shiraishi
Fuminori Moriyasu
Shigeki Ichimura
Ryo Metoki
Kunio Doi
Publication date
01-11-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 11/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1852-1

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