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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 3/2019

01-03-2019 | Anal Cancer | Original Article

Prognostic significance of inflammatory-related parameters in patients with anal canal cancer

Authors: Francesca De Felice, Filippo Lorenzo Rubini, Luca Romano, Nadia Bulzonetti, Rossella Caiazzo, Daniela Musio, Vincenzo Tombolini

Published in: International Journal of Colorectal Disease | Issue 3/2019

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Abstract

Purpose

To investigate the correlation between inflammatory-related parameters and overall survival (OS) and disease-free survival (DFS) in anal canal cancer population.

Methods and materials

Patients diagnosed with anal canal carcinoma and treated with curative intent chemoradiotherapy (CRT) were included. Data about pre-treatment complete blood count were collected. Neutrophil to lymphocyte ratio (NLR), fibrinogen (F), and a combination of these (F-NLR score) were correlated with OS.

Results

A total of 58 patients were enrolled. In multivariate analysis, the strongest OS prognostic factor was NLR, with a hazard ratio (HR) for low NLR compared to high NLR of 1.30 (95% confidence interval 1.01–14.12). Kaplan-Meier survival analysis showed that patients with high NLR, F, and F-NLR had significantly shorter OS and DFS.

Conclusion

To our knowledge, this is the first study providing evidence that elevated pre-treatment NLR, F, and F-NLR score significantly correlate with worse survival outcomes in patients with anal canal carcinoma. In view of our findings, future clinical trials in anal canal cancer patients are warranted to verify our results.
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Metadata
Title
Prognostic significance of inflammatory-related parameters in patients with anal canal cancer
Authors
Francesca De Felice
Filippo Lorenzo Rubini
Luca Romano
Nadia Bulzonetti
Rossella Caiazzo
Daniela Musio
Vincenzo Tombolini
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 3/2019
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-018-03225-7

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