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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2019

Open Access 01-12-2019 | Anakinra | Letter

Efficacy of canakinumab as first-line biologic agent in adult-onset Still’s disease

Authors: Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A. Dinarello, Elena Baldissera, Lorenzo Dagna

Published in: Arthritis Research & Therapy | Issue 1/2019

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Excerpt

Adult-onset Still’s disease (AOSD) is a rare condition characterized by fever, arthritis, skin rash, and multi-organ inflammation. The pathogenesis is mediated by the pro-inflammatory cytokine interleukin (IL)-1β, as confirmed by the clinical efficacy of selective blockade. Anakinra, a recombinant inhibitor of the IL-1β receptor, currently represents the cornerstone of biologic therapy [1]. …
Literature
1.
Cavalli G, Franchini S, Aiello P, Guglielmi B, Berti A, Campochiaro C, Sabbadini MG, Baldissera E, Dagna L. Efficacy and safety of biological agents in adult-onset Still's disease. Scand J Rheumatol. 2015;44(4):309–14.CrossRef
2.
Junge G, Mason J, Feist E. Adult onset Still’s disease-the evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review). Semin Arthritis Rheum. 2017;47(2):295–302.CrossRefPubMedCentral
3.
Colafrancesco S, Priori R, Valesini G, Argolini L, Baldissera E, Bartoloni E, Cammelli D, Canestrari G, Cantarini L, Cavallaro E, et al. Response to Interleukin-1 inhibitors in 140 Italian patients with adult-onset Still’s disease: a multicentre retrospective observational study. Front Pharmacol. 2017;8:369.CrossRefPubMedCentral
4.
Cavalli G, Dinarello CA. Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies. Rheumatology (Oxford). 2015;54(12):2134–44.
5.
Pouchot J, Arlet JB. Biological treatment in adult-onset Still’s disease. Best Pract Res Clin Rheumatol. 2012;26(4):477–87.CrossRefPubMedCentral
Metadata
Title
Efficacy of canakinumab as first-line biologic agent in adult-onset Still’s disease
Authors
Giulio Cavalli
Alessandro Tomelleri
Giacomo De Luca
Corrado Campochiaro
Charles A. Dinarello
Elena Baldissera
Lorenzo Dagna
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Anakinra
Published in
Arthritis Research & Therapy / Issue 1/2019
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-019-1843-9

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Developed by: Springer Medicine
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