Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Geriatrics
Published in: BMC Geriatrics 1/2019

Open Access 01-12-2019 | Research article

An augmented prescribed exercise program (APEP) to improve mobility of older acute medical patients – a randomized, controlled pilot and feasibility trial

Authors: Tobias Braun, Christian Grüneberg, Kirsten Süßmilch, Max Wiessmeier, Isabel Schwenk, Sarah Eggert, Annika Machleit-Ebner, Irene Harras, Christian Thiel

Published in: BMC Geriatrics | Issue 1/2019

Login to get access

Abstract

Background

There is inconclusive evidence for the effectiveness of additional exercise in older hospital patients. The aims of this study were (1) to assess the feasibility of an augmented prescribed exercise program (APEP) in older acute medical patients and (2) to measure the potential effects of APEP on mobility capacity in order to assess the feasibility of a large full-scale study.

Methods

We conducted a single-center, prospective, parallel-group, single-blinded, randomized (1:1) controlled pilot and feasibility trial. Participants were recruited from acute geriatric wards of a general hospital. Key inclusion criteria were: age ≥ 65 years and walking ability. Key exclusion criteria were severe cognitive impairment and medical restriction for physical exercise interventions.
Both groups received usual care, including physiotherapy. Intervention group participants were scheduled for additional exercise sessions (20–30 min, 4-5x/week). Feasibility of the trial design was assessed along pre-defined criteria for process, resources and management. Feasibility of the APEP intervention was analyzed by means of adherence, compliance and safety. Outcomes were measured at baseline and prior to hospital discharge. The primary outcome was mobility capacity (de Morton Mobility Index; DEMMI). Secondary outcomes were walking ability, physical endurance, fear of falling, frailty and length of stay.

Results

Thirty-five participants were recruited (recruitment rate 20.3%). We lost 7 participants to follow-up (retention rate: 80%). Intervention group participants (n = 17) each participated in 5.3 ± 2.2 additional exercise sessions (mean duration: 23.2 ± 4.0 min; mean adherence rate 78% ± 26%). No severe adverse events occurred during study assessments or APEP sessions.
There were no statistically significant differences in mean change scores in any outcome measure. A sample of 124 participants would be required to detect a difference of 4 DEMMI points (ES = 0.45) with a power of 80%.

Conclusions

This small feasibility RCT indicates that an APEP intervention may be safe and feasible in older acute medical patients. APEP may possibly induce small to moderate effects on mobility, but the clinical relevance of these effects may be limited. These results inform the planning of a larger-scale phase III study.

Trial registration

German Clinical Trials Register (DRKS00011262). Registered 27 October 2016.
Appendix
Available only for authorised users
Literature
1.
Fisher S, Ottenbacher KJ, Goodwin JS, Graham JE, Ostir GV. Short Physical Performance Battery in hospitalized older adults. Aging Clin Exp Res. 2009;21:445–52.PubMedPubMedCentralCrossRef
2.
Hubbard RE, Eeles EMP, Rockwood MRH, Fallah N, Ross E, Mitnitski A, Rockwood K. Assessing balance and mobility to track illness and recovery in older inpatients. J Gen Intern Med. 2011;26:1471–8.PubMedPubMedCentralCrossRef
3.
4.
Callen BL, Mahoney JE, Wells TJ, Enloe M, Hughes S. Admission and discharge mobility of frail hospitalized older adults. Medsurg Nurs. 2004;13:156–63.PubMed
5.
Ostir GV, Berges I, Ottenbacher KJ, Fisher SR, Barr E, Hebel JR, Guralnik JM. Gait Speed and Dismobility in Older Adults. Archives of Physical. Med Rehabil. 2015;96:1641–5.CrossRef
6.
Stier-Jarmer M, Grill E, Müller M, Strobl R, Quittan M, Stucki G. Validation of the comprehensive ICF Core Set for patients in geriatric post-acute rehabilitation facilities. J Rehabil Med. 2011;43:102–12.PubMed
7.
Brown CJ, Redden DT, Flood KL, Allman RM. The underrecognized epidemic of low mobility during hospitalization of older adults. J Am Geriatr Soc. 2009;57:1660–5.PubMedCrossRef
8.
Pedersen MM, Bodilsen AC, Petersen J, Beyer N, Andersen O, Lawson-Smith L, et al. Twenty-four-hour mobility during acute hospitalization in older medical patients. J Gerontol A Biol Sci Med Sci. 2013;68:331–7.PubMedCrossRef
9.
10.
Villumsen M, Jorgensen MG, Andreasen J, Rathleff MS, Mølgaard CM. Very Low Levels of Physical Activity in Older Patients During Hospitalization at an Acute Geriatric Ward: A Prospective Cohort Study. J Aging Phys Act. 2015;23:542–9.PubMedCrossRef
11.
Callen BL, Mahoney JE, Grieves CB, Wells TJ, Enloe M. Frequency of hallway ambulation by hospitalized older adults on medical units of an academic hospital. Geriatr Nurs. 2004;25:212–7.PubMedCrossRef
12.
Tudor-Locke C, Schuna JM, Barreira TV, Mire EF, Broyles ST, Katzmarzyk PT, Johnson WD. Normative steps/day values for older adults: NHANES 2005–2006. J. Gerontol. A Biol. Sci. Med. Sci. 2013;68:1426–32.PubMedCrossRef
13.
Smith P, Galea M, Woodward M, Said C, Dorevitch M. Physical activity by elderly patients undergoing inpatient rehabilitation is low: An observational study. Aust J Physiother. 2008;54:209–13.PubMedCrossRef
14.
Fisher SR, Goodwin JS, Protas EJ, Kuo Y-F, Graham JE, Ottenbacher KJ, Ostir GV. Ambulatory activity of older adults hospitalized with acute medical illness. J Am Geriatr Soc. 2011;59:91–5.PubMedCrossRef
15.
Evans D, Hodgkinson B, Lambert L, Wood J. Falls risk factors in the hospital setting: A systematic review. Int J Nurs Prac. 2001;7:38–45.CrossRef
16.
Oliver D, Daly F, Martin FC, McMurdo MET. Risk factors and risk assessment tools for falls in hospital in-patients: A systematic review. Age Ageing. 2004;33:122–30.PubMedCrossRef
17.
Preyde M, Brassard K. Evidence-based risk factors for adverse health outcomes in older patients after discharge home and assessment tools: A systematic review. J Evid Based Soc Work. 2011;8:445–68.PubMedCrossRef
18.
Brown CJ, Friedkin RJ, Inouye SK. Prevalence and outcomes of low mobility in hospitalized older patients. J Am Geriatr Soc. 2004;52:1263–70.PubMedCrossRef
19.
Fried LP, Bandeen-Roche K, Chaves PH, Johnson BA. Preclinical mobility disability predicts incident mobility disability in older women. J. Gerontol. A Biol. Sci. Med. Sci. 2000;55:M43–52.PubMedCrossRef
20.
Brown CJ, Flood KL. Mobility limitation in the older patient: a clinical review. JAMA. 2013;310:1168–77.PubMedCrossRef
21.
Sager MA, Franke T, Inouye SK, Landefeld CS, Morgan TM, Rudberg MA, et al. Functional outcomes of acute medical illness and hospitalization in older persons. Arch. Intern. Med. 1996;156:645–52.PubMedCrossRef
22.
de Morton NA, Keating JL, Jeffs K. Exercise for acutely hospitalised older medical patients. Cochrane Database Syst Rev. 2007:CD005955.
23.
Kosse NM, Dutmer AL, Dasenbrock L, Bauer JM, Lamoth CJC. Effectiveness and feasibility of early physical rehabilitation programs for geriatric hospitalized patients: a systematic review. BMC Geriatr. 2013;13:107.PubMedPubMedCentralCrossRef
24.
Martinez-Velilla N, Cadore L, Casas-Herrero A, Idoate-Saralegui F, Izquierdo M. Physical Activity and Early Rehabilitation in Hospitalized Elderly Medical Patients: Systematic Review of Randomized Clinical Trials. J Nutr Health Aging. 2016;20:738–51.PubMedCrossRef
25.
de Morton NA, Keating JL, Jeffs K. The effect of exercise on outcomes for older acute medical inpatients compared with control or alternative treatments: a systematic review of randomized controlled trials. Clin Rehabil. 2007;21:3–16.PubMedCrossRef
26.
Kolb G, Breuninger K, Gronemeyer S, van den Heuvel D, Lübke N, Lüttje D, et al. 10 Jahre geriatrische frührehabilitative Komplexbehandlung im DRG-System. Z Gerontol Geriatr. 2014;47:6–12.PubMedCrossRef
27.
Siebens H, Aronow H, Edwards D, Ghasemi Z. A randomized controlled trial of exercise to improve outcomes of acute hospitalization in older adults. J Am Geriatr Soc. 2000;48:1545–52.PubMedCrossRef
28.
Mudge AM, Giebel AJ, Cutler AJ. Exercising body and mind: An integrated approach to functional independence in hospitalized older people. J Am Geriatr Soc. 2008;56:630–5.PubMedCrossRef
29.
de Morton NA, Keating JL, Berlowitz DJ, Jackson B, Lim WK. Additional exercise does not change hospital or patient outcomes in older medical patients: a controlled clinical trial. Aust J Physiother. 2007;53:105–11.PubMedCrossRef
30.
Jeffs KJ, Berlowitz DJ, Grant S, Lawlor V, Graco M, de Morton NA, et al. An enhanced exercise and cognitive programme does not appear to reduce incident delirium in hospitalised patients: a randomised controlled trial. BMJ Open. 2013;3:e002569.PubMedPubMedCentralCrossRef
31.
Killey B, Watt E. The effect of extra walking on the mobility, independence and exercise self-efficacy of elderly hospital in-patients: A pilot study. Contemp Nurse. 2006;22:120–33.PubMedCrossRef
32.
Oestergaard AS, Mathiesen MH, Karlsen A, Turtumoeygaard IF, Vahlgren J, Kjaer M, Beyer N. In acutely admitted geriatric patients, offering increased physical activity during hospitalization decreases length of stay and can improve mobility. Transl Sports Med. 2018;1:46–53.CrossRef
33.
Said CM, Morris ME, Woodward M, Churilov L, Bernhardt J. Enhancing physical activity in older adults receiving hospital based rehabilitation: a phase II feasibility study. BMC Geriatr. 2012;12:26.PubMedPubMedCentralCrossRef
34.
Tibaek S, Andersen CW, Pedersen SF, Rudolf KS. Does progressive resistance strength training as additional training have any measured effect on functional outcomes in older hospitalized patients? A single-blinded randomized controlled trial. Clin Rehabil. 2014;28:319–28.PubMedCrossRef
35.
Said CM, Morris ME, McGinley JL, Szoeke C, Workman B, Liew D, et al. Additional structured physical activity does not improve walking in older people (60years) undergoing inpatient rehabilitation: A randomised trial. J Physiother. 2018;64:237–44.PubMedCrossRef
36.
McCullagh R, O’Connell E, O’Meara S, Perry I, Fitzgerald A, O’Connor K, et al. A study protocol of a randomised controlled trial to measure the effects of an augmented prescribed exercise programme (APEP) for frail older medical patients in the acute setting. BMC Geriatr. 2016;16:451.CrossRef
37.
McCullagh R, O’Connell E, O’Meara S, Dahly D, Horgan NF, Timmons S. An Augmented Prescribed Exercise Programme (APEP) for Frail Medical Inpatients: A Randomised Controlled Trial. Age Ageing. 2018;47:v13–60.CrossRef
38.
39.
Eldridge SM, Chan CL, Campbell MJ, Bond CM, Hopewell S, Thabane L, Lancaster GA. CONSORT 2010 statement: Extension to randomised pilot and feasibility trials. Pilot Feasibility Stud. 2016;2:726.CrossRef
40.
Hoffmann TC, Glasziou PP, Boutron I, Milne R, Perera R, Moher D, et al. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ. 2014;348:g1687.CrossRefPubMed
41.
Slade SC, Dionne CE, Underwood M, Buchbinder R, Beck B, Bennell K, et al. Consensus on Exercise Reporting Template (CERT): Modified Delphi Study. Phys Ther. 2016;96:1514–24.PubMedCrossRef
42.
Mehrholz J, Wagner K, Rutte K, Meissner D, Pohl M. Predictive validity and responsiveness of the functional ambulation category in hemiparetic patients after stroke. Arch Phys Med Rehabil. 2007;88:1314–9.PubMedCrossRef
43.
Podsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39:142–8.PubMedCrossRef
44.
Folstein MF, Robins LN, Helzer JE. The Mini-Mental State Examination. Arch Gen Psychiatry. 1983;40:812.PubMedCrossRef
45.
Borg G. Anstrengungsempfinden und körperliche Aktivität. Deutsches Ärzteblatt. 2004;101:1016–21.
46.
Vogler CM, Sherrington C, Ogle SJ, Lord SR. Reducing risk of falling in older people discharged from hospital: a randomized controlled trial comparing seated exercises, weight-bearing exercises, and social visits. Arch Phys Med Rehabil. 2009;90:1317–24.PubMedCrossRef
47.
Gardner MM, Buchner DM, Robertson MC, Campbell AJ. Practical implementation of an exercise-based falls prevention programme. Age Ageing. 2001;30:77–83.PubMedCrossRef
48.
Littbrand H, Rosendahl E, Lindelof N, Lundin-Olsson L, Gustafson Y, Nyberg L. A high-intensity functional weight-bearing exercise program for older people dependent in activities of daily living and living in residential care facilities: evaluation of the applicability with focus on cognitive function. Phys Ther. 2006;86:489–98.PubMed
49.
Braun T, Grüneberg C, Thiel C, Schulz R-J. Measuring mobility in older hospital patients with cognitive impairment using the de Morton Mobility Index. BMC Geriatr. 2018;18:100.PubMedPubMedCentralCrossRef
50.
Braun T, Thiel C, Schulz R-J, Grüneberg C. Reliability of mobility measures in older medical patients with cognitive impairment. BMC Geriatr. 2019;19:20.PubMedPubMedCentralCrossRef
51.
Braun T, Grüneberg C, Coppers A, Tofaute L, Thiel C. Comparison of the de Morton Mobility Index and Hierarchical Assessment of Balance and Mobility in older acute medical patients. J Rehabil Med. 2018;50:292–301.PubMedCrossRef
52.
de Morton NA, Davidson M, Keating JL. The de Morton Mobility Index (DEMMI): an essential health index for an ageing world. Health Qual Life Outcomes. 2008;6:63.PubMedPubMedCentralCrossRef
53.
Braun T, Schulz R-J, Hoffmann M, Reinke J, Tofaute L, Urner C, et al. German version of the de Morton Mobility Index. First clinical results from the process of the cross-cultural adaptation. Z Gerontol Geriatr. 2015;48:154–63.PubMedCrossRef
54.
Braun T, Schulz R-J, Reinke J, van Meeteren NL, de Morton NA, Davidson M, et al. Reliability and validity of the German translation of the de Morton Mobility Index (DEMMI) performed by physiotherapists in patients admitted to a sub-acute inpatient geriatric rehabilitation hospital. BMC Geriatr. 2015;15:1660.CrossRef
55.
MacKnight C, Rockwood K. Rasch analysis of the hierarchical assessment of balance and mobility (HABAM). J Clin Epidemiol. 2000;53:1242–7.PubMedCrossRef
56.
Rockwood K, Rockwood MRH, Andrew MK, Mitnitski A. Reliability of the hierarchical assessment of balance and mobility in frail older adults. J Am Geriatr Soc. 2008;56:1213–7.PubMedCrossRef
57.
Braun T, Rieckmann A, Grüneberg C, Marks D, Thiel C. Hierarchical assessment of balance and mobility - German translation and cross-cultural adaptation. Zeitschrift für Gerontologie und Geriatrie. 2016;49:386–97.PubMedCrossRef
58.
Graham JE, Ostir GV, Fisher SR, Ottenbacher KJ. Assessing walking speed in clinical research: a systematic review. J Eval Clin Pract. 2008;14:552–62.PubMedPubMedCentralCrossRef
59.
Peel NM, Kuys SS, Klein K. Gait speed as a measure in geriatric assessment in clinical settings: a systematic review. J Gerontol A Biol Sci Med Sci. 2013;68:39–46.PubMedCrossRef
60.
Holden MK, Gill KM, Magliozzi MR, Nathan J, Piehl-Baker L. Clinical gait assessment in the neurologically impaired. Reliability and meaningfulness. Phys Ther. 1984;64:35–40.PubMed
61.
Bean JF, Kiely DK, Leveille SG, Herman S, Huynh C, Fielding R, Frontera W. The 6-minute walk test in mobility-limited elders: what is being measured? J. Gerontol. A Biol. Sci. Med. Sci. 2002;57:6.CrossRef
62.
63.
64.
Roberts H, Denison H, Martin H, Patel H, Syddall H, Cooper C, Sayer A. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40:423–9.PubMedCrossRef
65.
Yardley L, Beyer N, Hauer K, Kempen G, Piot-Ziegler C, Todd C. Development and initial validation of the Falls Efficacy Scale-International (FES-I). Age Ageing. 2005;34:614–9.PubMedCrossRef
66.
Zijlstra GAR, van Haastregt JCM, van Rossum E, van Eijk JTM, Yardley L, Kempen GIJM. Interventions to reduce fear of falling in community-living older people: a systematic review. J Am Geriatr Soc. 2007;55:603–15.PubMedCrossRef
67.
Mahoney FI, Barthel DW. Functional Evaluation: The Barthel Index. Md State Med J. 1965;14:61–5.PubMed
68.
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.PubMedCrossRef
69.
Terwee CB, Bot SDM, de Boer MR, van der Windt DAWM, Knol DL, Dekker J, et al. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007;60:34–42.PubMedCrossRef
70.
Soares Menezes KVR, Auger C, de Souza Menezes WR, Guerra RO. Instruments to evaluate mobility capacity of older adults during hospitalization: A systematic review. Arch Gerontol Geriatr. 2017;72:67–79.PubMedCrossRef
71.
Whitehead AL, Julious SA, Cooper CL, Campbell MJ. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Stat Methods Med Res. 2016;25:1057–73.PubMedCrossRef
72.
73.
Fritz CO, Morris PE, Richler JJ. Effect size estimates: current use, calculations, and interpretation. J Exp Psychol Gen. 2012;141:2–18.PubMedCrossRef
74.
Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. New York, NY: Psychology Press; 2009.
75.
Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.PubMedCrossRef
76.
Nyman SR, Victor CR. Older people’s recruitment, sustained participation, and adherence to falls prevention interventions in institutional settings: A supplement to the Cochrane systematic review. Age Ageing. 2011;40:430–6.PubMedCrossRef
77.
Lindemann U, Beck L, Becker C. Effect of course length and corridor width on the 2-minute walk test performance in geriatric patients. Clin Rehabil. 2017;31:273–7.PubMedCrossRef
78.
Scrivener K, Jones T, Schurr K, Graham PL, Dean CM. After-hours or weekend rehabilitation improves outcomes and increases physical activity but does not affect length of stay: a systematic review. J Physiother. 2015;61:61–7.PubMedCrossRef
79.
Mallery LH, MacDonald EA, Hubley-Kozey CL, Earl ME, Rockwood K, MacKnight C. The feasibility of performing resistance exercise with acutely ill hospitalized older adults. BMC Geriatr. 2003;3:3.PubMedPubMedCentralCrossRef
80.
Deng LX, Patel K, Miaskowski C, Maravilla I, Schear S, Garrigues S, et al. Prevalence and Characteristics of Moderate to Severe Pain among Hospitalized Older Adults. J Am Geriatr Soc. 2018;66:1744–51.PubMedCrossRefPubMedCentral
81.
Zdanys KF, Steffens DC. Sleep Disturbances in the Elderly. Psychiatr Clin North Am. 2015;38:723–41.PubMedCrossRef
82.
Zengarini E, Ruggiero C, Perez-Zepeda MU, Hoogendijk EO, Vellas B, Mecocci P, Cesari M. Fatigue: Relevance and implications in the aging population. Exp Gerontol. 2015;70:78–83.PubMedCrossRef
83.
Herr K, Titler M. Acute pain assessment and pharmacological management practices for the older adult with a hip fracture: Review of ED trends. J Emerg Nurs. 2009;35:312–20.PubMedCrossRef
84.
Morrison RS, Magaziner J, McLaughlin MA, Orosz G, Silberzweig SB, Koval KJ, Siu AL. The impact of post-operative pain on outcomes following hip fracture. Pain. 2003;103:303–11.PubMedCrossRef
85.
86.
O’Hare L, Savage E, McCullagh R, Bantry White E, Fitzgerald E, Timmons S. Frail older adults’ perceptions of an in-hospital structured exercise intervention. Physiotherapy. 2017;103:478–84.PubMedCrossRef
87.
Bohannon RW, Glenney SS. Minimal clinically important difference for change in comfortable gait speed of adults with pathology: a systematic review. J Eval Clin Pract. 2014;20:295–300.PubMedCrossRef
88.
Perera S, Mody SH, Woodman RC, Studenski SA. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc. 2006;54:743–9.PubMedCrossRef
89.
90.
Peiris CL, Taylor NF, Shields N. Extra physical therapy reduces patient length of stay and improves functional outcomes and quality of life in people with acute or subacute conditions: A systematic review. Arch Phys Med Rehabil. 2011;92:1490–500.PubMedCrossRef
Metadata
Title
An augmented prescribed exercise program (APEP) to improve mobility of older acute medical patients – a randomized, controlled pilot and feasibility trial
Authors
Tobias Braun
Christian Grüneberg
Kirsten Süßmilch
Max Wiessmeier
Isabel Schwenk
Sarah Eggert
Annika Machleit-Ebner
Irene Harras
Christian Thiel
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2019
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-019-1246-4

Other articles of this Issue 1/2019

BMC Geriatrics 1/2019 Go to the issue

Research article

Effect of deep tissue laser therapy treatment on peripheral neuropathic pain in older adults with type 2 diabetes: a pilot randomized clinical trial

Research article

Temporal trends in incidence, recurrence and prevalence of stroke in an era of ageing populations, a longitudinal study of the total Swedish population

Research article

Procalcitonin is not an independent predictor of 30-day mortality, albeit predicts pneumonia severity in patients with pneumonia acquired outside the hospital

Research article

Objective physical measures and their association with subjective functional limitations in a representative study population of older Thais

Research article

Development of an evaluation tool for geriatric rehabilitation care

Research article

Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits