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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2014

Open Access 01-12-2014 | Research article

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

Authors: Rebecca JM Hurst, Thomas Hopwood, Amanda L Gallagher, Frederick A Partridge, Timothy Burgis, David B Sattelle, Kathryn J Else

Published in: BMC Infectious Diseases | Issue 1/2014

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Abstract

Background

Trichuriasis is a parasitic disease caused by the human whipworm, Trichuris trichiura. It affects millions worldwide, particularly in the tropics. This nematode parasite burrows into the colonic epithelium resulting in inflammation and morbidity, especially in children. Current treatment relies mainly on general anthelmintics such as mebendazole but resistance to these drugs is increasingly problematic. Therefore, new treatments are urgently required.

Methods

The prospect of using the retinoid X receptor (RXR) antagonist HX531 as a novel anthelmintic was investigated by carrying out multiple viability assays with the mouse whipworm Trichuris muris.

Results

HX531 reduced both the motility and viability of T. muris at its L3, L4 and adult stages. Further, bioinformatic analyses show that the T. muris genome possesses an RXR-like receptor, a possible target for HX531.

Conclusions

The study suggested that Trichuris-specific RXR antagonists may be a source of much-needed novel anthelmintic candidates for the treatment of trichuriasis. The identification of an RXR-like sequence in the T. muris genome also paves the way for further research based on this new anthelmintic lead compound.
Appendix
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Metadata
Title
An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro
Authors
Rebecca JM Hurst
Thomas Hopwood
Amanda L Gallagher
Frederick A Partridge
Timothy Burgis
David B Sattelle
Kathryn J Else
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2014
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-520

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