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01-10-2013 | Correspondence

Amyloid and tau: neither chicken nor egg but two partners in crime!

Authors: Johannes Attems, Kurt A. Jellinger

Published in: Acta Neuropathologica | Issue 4/2013

Excerpt

We read with great interest the recent correspondence by Mann and Hardy published in Acta Neuropathologica [15]. The authors critically discuss a novel concept for the pathogenesis of Alzheimer’s disease (AD) suggested by Braak and Del Tredici [7], namely the assumption that AD-associated tau pathology begins in the locus coeruleus (LC) and causes amyloid-β (Aβ) pathology. The LC would therefore represent the primary manifestation site of AD. …

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Title: Amyloid and tau: neither chicken nor egg but two partners in crime!
Authors: Johannes Attems
Kurt A. Jellinger
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 4/2013
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-013-1167-9

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