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01-10-2013 | Correspondence

Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYC^lowBCL2^low subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas

Authors: Anna Brunn, Inga Nagel, Manuel Montesinos-Rongen, Wolfram Klapper, Inga Vater, Werner Paulus, Volkmar Hans, Ingmar Blümcke, Joachim Weis, Reiner Siebert, Martina Deckert

Published in: Acta Neuropathologica | Issue 4/2013

Excerpt

“Double-hit” (DH) systemic diffuse large B cell lymphomas (DLBCL), defined by molecular cytogenetics as breakpoint affecting the MYC locus concomitantly with a breakpoint affecting the BCL2 and/or BCL6 locus as well as double-expressing (DE) lymphomas defined by immunohistochemistry (IHC) as coexpression of MYC with BCL2 proteins, carry a poor prognosis [2‐4]. Primary lymphoma of the CNS (PCNSL) is a specific DLBCL with particular target organ manifestation and a significantly adverse outcome. To investigate potential mechanisms leading to these features, we studied a series of 50 PCNSL (immunocompetent patients) for MYC, BCL2, and BCL6 breaks by FISH and MYC, BCL2, and BCL6 expression by IHC. …

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Title: Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYClowBCL2low subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas
Authors: Anna Brunn
Inga Nagel
Manuel Montesinos-Rongen
Wolfram Klapper
Inga Vater
Werner Paulus
Volkmar Hans
Ingmar Blümcke
Joachim Weis
Reiner Siebert
Martina Deckert
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 4/2013
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-013-1169-7

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Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYC^lowBCL2^low subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas

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