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01-04-2019 | Alzheimer's Disease | Original Article

Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease Among Han Chinese

Authors: Qian Yang, Kang Chen, Hanlin Zhang, Wanying Zhang, Changlin Gong, Qing Zhang, Pan Liu, Tianyi Sun, Yuanyuan Xu, Xiaojing Qian, Wenying Qiu, Chao Ma

Published in: Neuroscience Bulletin | Issue 2/2019

Abstract

In this study, the distribution of five Alzheimer’s disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4.482, P = 0.004), the RS2305421 GG genotype (adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype (adjusted OR = 2.375, P = 0.028) were associated with a higher score on the ABC (Aβ plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD, the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research.

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Title: Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease Among Han Chinese
Authors: Qian Yang
Kang Chen
Hanlin Zhang
Wanying Zhang
Changlin Gong
Qing Zhang
Pan Liu
Tianyi Sun
Yuanyuan Xu
Xiaojing Qian
Wenying Qiu
Chao Ma
Publication date: 01-04-2019
Publisher: Springer Singapore
Keywords: Alzheimer's Disease
Alzheimer's Disease
Pathology
Dementia
Dementia
Published in: Neuroscience Bulletin / Issue 2/2019
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-019-00343-2

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Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer’s Disease Among Han Chinese

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