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01-09-2016 | Original Communication

Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease

Authors: Toru Ishii, Nobukatsu Sawamoto, Hayato Tabu, Hidekazu Kawashima, Tomohisa Okada, Kaori Togashi, Ryosuke Takahashi, Hidenao Fukuyama

Published in: Journal of Neurology | Issue 9/2016

Abstract

Patients with Parkinson’s disease (PD) have been suggested to share personality traits characterised by low novelty-seeking and high harm-avoidance. Although a link between novelty-seeking and dopamine is hypothesised, the link is not fully supported by 6-[¹⁸F]fluoro-l-dopa positron emission tomography (PET) studies. Meanwhile, tractography studies with magnetic resonance imaging (MRI) link personality to the connectivity of the striatum in healthy subjects. Here, we investigated neurochemical and anatomical correlates of characteristic personality traits in PD. Sixteen PD patients and 28 healthy controls were assessed using the Temperament and Character Inventory. All patients and 17 randomly selected controls were scanned with 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-¹¹C-methyl]tropane ([¹¹C]CFT) PET to measure striatal dopamine transporter availability. All subjects were scanned with MRI to evaluate the connectivity of the striatum using probabilistic tractography. PET findings revealed no correlation of novelty-seeking and harm-avoidance with [¹¹C]CFT uptake in patients or controls. Novelty-seeking correlated positively with the connectivity strength of the striatum with the hippocampus and amygdala in both patients and controls. Harm-avoidance and the fibre connectivity strength of the striatum including ventral area with the amygdala correlated negatively in patients and positively in controls, which differed significantly between the groups. Our data support the notion that the fibre connectivity of the striatum with limbic and frontal areas underlies the personality profile. Furthermore, our findings suggest that higher harm-avoidance in PD is linked to alterations of the network, including the nucleus accumbens and amygdala.

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Title: Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease
Authors: Toru Ishii
Nobukatsu Sawamoto
Hayato Tabu
Hidekazu Kawashima
Tomohisa Okada
Kaori Togashi
Ryosuke Takahashi
Hidenao Fukuyama
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 9/2016
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-016-8206-0

At a glance: The STEP trials

Springer Medicine

Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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