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Open Access 01-12-2013 | Research article

Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration

Authors: Ling Zhao, Jixin Liu, Xilin Dong, Yulin Peng, Kai Yuan, Fumei Wu, Jinbo Sun, Qiyong Gong, Wei Qin, Fanrong Liang

Published in: The Journal of Headache and Pain | Issue 1/2013

Abstract

Background

Advanced neuroimaging approaches have been employed to prove that migraine was a central nervous system disorder. This study aims to examine resting-state abnormalities in migraine without aura (MWoA) patients stratified by disease duration, and to explore the neuroimaging markers for reflecting the disease duration.

Methods

40 eligible MWoA patients and 20 matched healthy volunteers were included in the study. Regional homogeneity (ReHo) analysis was used to identify the local features of spontaneous brain activity in MWoA patients stratified by disease duration, and analysis was performed to investigate the correlation of overlapped brain dysfunction in MWoA patients with different disease duration (long-term and short-term) and course of disease.

Results

Compared with healthy controls, MWoA patients with long-term disease duration showed comprehensive neuronal dysfunction than patients with short-term disease duration. In addition, increased average ReHo values in the thalamus, brain stem, and temporal pole showed significantly positive correlations with the disease duration. On the contrary, ReHo values were negatively correlated with the duration of disease in the anterior cingulate cortex, insula, posterior cingulate cortex and superior occipital gyrus.

Conclusions

Our findings of progressive brain damage in relation to increasing disease duration suggest that migraine without aura is a progressive central nervous disease, and the length of the disease duration was one of the key reasons to cause brain dysfunction in MwoA patients. The repeated migraine attacks over time result in resting-state abnormalities of selective brain regions belonging to the pain processing and cognition. We predict that these brain regions are sensitive neuroimaging markers for reflecting the disease duration of migraine patients without aura.

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Title: Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration
Authors: Ling Zhao
Jixin Liu
Xilin Dong
Yulin Peng
Kai Yuan
Fumei Wu
Jinbo Sun
Qiyong Gong
Wei Qin
Fanrong Liang
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/1129-2377-14-85

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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