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European Archives of Oto-Rhino-Laryngology

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11-04-2023 | Allergic Rhinitis | Rhinology

Association between poly-sensitisation and sensitisation to staphylococcal enterotoxin A and B affecting allergic severity in children

Authors: Young-Ha Lee, Minheon Kim, Cheol Hyo Ku, Hyun Su Lee, Joo Hyung Lee, Dong Hwan Kwon, Eun Jung Lee

Published in: European Archives of Oto-Rhino-Laryngology | Issue 9/2023

Abstract

Purpose

Accumulating evidence suggests that Staphylococcus aureus plays a significant role as a disease modifier in upper and lower airway diseases. We aimed to assess the association between staphylococcal enterotoxins (SEs) with allergic diseases and the degree of allergen sensitisation in children, which remains unclear.

Methods

We retrospectively reviewed the medical records of 455 patients aged 3–18 years between March 2018 and March 2022. Clinical history and demographic data were obtained. The baseline study included paranasal sinus X-ray scan, multiple allergen simultaneous test, and ImmunoCAP® for measuring serum total and specific immunoglobulin E (IgE) levels to allergens and staphylococcal enterotoxin A and B (SEA and SEB).

Results

The mean age was 9.77 ± 4.3 years. 133 patients (29.2%) were sensitised to one inhalant allergen, and 188 patients (41.3%) showed polysensitisation. Patients sensitised to SEs showed higher total and specific IgE levels and total eosinophil counts compared to non-SE-sensitised patients. Sensitisation to SEs is closely associated with polysensitisation to inhalant allergens and allergic multimorbidity. When the SE-IgE value was 0.35 or higher, the odds ratio for allergen polysensitisation was significantly higher than when the SE-IgE value was lower than 0.35.

Conclusions

Association between polysensitisation and sensitisation to SEs in children shows the higher the specific IgE levels for SEs, the higher the likelihood of polysensitisation. Considering the relationship between polysensitisation, high IgE levels, and the severity of allergic morbidity, sensitisation to SEs is thought to be related to allergy severity.

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Title: Association between poly-sensitisation and sensitisation to staphylococcal enterotoxin A and B affecting allergic severity in children
Authors: Young-Ha Lee
Minheon Kim
Cheol Hyo Ku
Hyun Su Lee
Joo Hyung Lee
Dong Hwan Kwon
Eun Jung Lee
Publication date: 11-04-2023
Publisher: Springer Berlin Heidelberg
Keywords: Allergic Rhinitis
Bronchial Asthma
Published in: European Archives of Oto-Rhino-Laryngology / Issue 9/2023
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-07968-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between poly-sensitisation and sensitisation to staphylococcal enterotoxin A and B affecting allergic severity in children

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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