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Open Access 01-12-2019 | Albuminuria | Research article

Number of parity is associated with low-grade albuminuria in middle-aged and elderly Chinese women

Authors: Kan Sun, Diaozhu Lin, Feng Qiling, Feng Li, Yiqin Qi, Wanting Feng, Meng Ren, Li Yan, Dan Liu

Published in: BMC Women's Health | Issue 1/2019

Abstract

Background

Women with a higher number of pregnancies have a higher risk of developing cardiovascular diseases. Subtle fluctuations in albumin excretion could be related to pathophysiologic changes in the vascular system. We aimed to investigate the possible association of parity with low-grade albuminuria.

Methods

We conducted a community-based study in 6495 women aged 40 years or older. Low-grade albuminuria was defined according to the highest quartile of urine albumin-to-creatinine ratio in participants free of micro- or macro-albuminuria.

Results

Parous women with a higher number of pregnancies had increased age, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), fasting plasma glucose (FPG), and fasting insulin, as well as decreased high-density lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR) levels, and proportion of menopause. The prevalence of low-grade albuminuria in parous women gradually increased with parity number. Compared with women with one childbirth, those with more than two childbirths were independently associated with a higher prevalent low-grade albuminuria (odds ratios [ORs] 1.41, 95% confidence interval [CI], 1.09–1.81) after multiple adjustments. In subgroup analysis after multiple adjustments, significant relation between parity number and prevalent low-grade albuminuria was detected in subjects age 55 years or older.

Conclusion

Number of parity is associated with prevalent low-grade albuminuria in middle-aged and elderly Chinese women without micro- or macro-albuminuria.

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Title: Number of parity is associated with low-grade albuminuria in middle-aged and elderly Chinese women
Authors: Kan Sun
Diaozhu Lin
Feng Qiling
Feng Li
Yiqin Qi
Wanting Feng
Meng Ren
Li Yan
Dan Liu
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Albuminuria
Published in: BMC Women's Health / Issue 1/2019
Electronic ISSN: 1472-6874
DOI: https://doi.org/10.1186/s12905-019-0814-2

At a glance: The STEP trials

Springer Medicine

Number of parity is associated with low-grade albuminuria in middle-aged and elderly Chinese women

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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