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Indian Journal of Hematology and Blood Transfusion

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01-06-2016 | Case Report

Aggressive Lymphomas Diagnosed in the Bone Marrow: Two Illustrative Cases

Authors: Rekha Bhat, Swati Pai, Kunal Das, Ashish Dixit

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2016

Abstract

Lymphomas with subtle patterns in the marrow can be a diagnostic challenge, unless a high index of suspicion is maintained. We present two patients with aggressive lymphomas who presented with cytopenias and the subsequent bone marrow examinations yielded surprising results. These cases highlight the potential usefulness of a bone marrow examination in the diagnosis of lymphomas in the absence of nodal or other tissue specimens.

Foucar K, Reichard K, Czuchlewski D (2010) Bone marrow pathology, 3rd edn. ASCP Press, Chicago

Swerdlow SH, International Agency for Research on Cancer., World Health Organization (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours, 4th edn. International Agency for Research on Cancer, Lyon

Ferreri AJ, Dognini GP, Campo E, Willemze R, Seymour JF, Bairey O, Martelli M, De Renz AO, Doglioni C, Montalban C, Tedeschi A, Pavlovsky A, Morgan S, Uziel L, Ferracci M, Ascani S, Gianelli U, Patriarca C, Facchetti F, Dalla Libera A, Pertoldi B, Horvath B, Szomor A, Zucca E, Cavalli F, Ponzoni M (2007) Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions. Haematologica 92(4):486–492CrossRefPubMed

Morice WG, Rodriguez FJ, Hoyer JD, Kurtin PJ (2005) Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases. Mod Pathol 18(4):495–502. doi:10.1038/modpathol.3800297 CrossRefPubMed

Yegappan S, Coupland R, Arber DA, Wang N, Miocinovic R, Tubbs RR, Hsi ED (2001) Angiotropic lymphoma: an immunophenotypically and clinically heterogeneous lymphoma. Mod Pathol 14(11):1147–1156. doi:10.1038/modpathol.3880450 CrossRefPubMed

Ponzoni M, Arrigoni G, Gould VE, Del Curto B, Maggioni M, Scapinello A, Paolino S, Cassisa A, Patriarca C (2000) Lack of CD 29 (beta1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis. Hum Pathol 31(2):220–226CrossRefPubMed

Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, Niitsu N, Kosugi H, Tsukamoto N, Miwa H, Asaoku H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T (2008) Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan. J Clin Oncol 26(19):3189–3195. doi:10.1200/JCO.2007.15.4278 CrossRefPubMed

Bazhenova L, Higginbottom P, Mason J (2006) Intravascular lymphoma: a role for single-agent rituximab. Leuk Lymphoma 47(2):337–341. doi:10.1080/10428190500300837 CrossRefPubMed

Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S (2007) Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol 25(21):3168–3173. doi:10.1200/JCO.2006.08.2313 CrossRefPubMed

10.

Farcet JP, Gaulard P, Marolleau JP, Le Couedic JP, Henni T, Gourdin MF, Divine M, Haioun C, Zafrani S, Goossens M et al (1990) Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta. Blood 75(11):2213–2219PubMed

11.

Vose J, Armitage J, Weisenburger D (2008) International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 26(25):4124–4130. doi:10.1200/JCO.2008.16.4558 CrossRefPubMed

12.

Mackey AC, Green L, Liang LC, Dinndorf P, Avigan M (2007) Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J Pediatr Gastroenterol Nutr 44(2):265–267. doi:10.1097/MPG.0b013e31802f6424 CrossRefPubMed

13.

Chen YH, Chadburn A, Evens AM, Winter JN, Gordon LI, Chenn A, Goolsby C, Peterson L (2011) Clinical, morphologic, immunophenotypic, and molecular cytogenetic assessment of CD4-/CD8-gammadelta T-cell large granular lymphocytic leukemia. Am J Clin Pathol 136(2):289–299. doi:10.1309/AJCPTFFQ18JMYKDF CrossRefPubMed

14.

Tripodo C, Iannitto E, Florena AM, Pucillo CE, Piccaluga PP, Franco V, Pileri SA (2009) Gamma-delta T-cell lymphomas. Nat Rev Clin Oncol 6(12):707–717. doi:10.1038/nrclinonc.2009.169 CrossRefPubMed

15.

Foppoli M, Ferreri AJ (2014) Gamma-delta t-cell lymphomas. Eur J Haematol. doi:10.1111/ejh.12439 PubMed

16.

Belhadj K, Reyes F, Farcet JP, Tilly H, Bastard C, Angonin R, Deconinck E, Charlotte F, Leblond V, Labouyrie E, Lederlin P, Emile JF, Delmas-Marsalet B, Arnulf B, Zafrani ES, Gaulard P (2003) Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood 102(13):4261–4269. doi:10.1182/blood-2003-05-1675 CrossRefPubMed

17.

Nosari A, Oreste PL, Biondi A, Costantini MC, Santoleri L, Intropido L, Muti G, Pungolino E, Gargantini L, Morra E (1999) Hepato-splenic gammadelta T-cell lymphoma: a rare entity mimicking the hemophagocytic syndrome. Am J Hematol 60(1):61–65. doi:10.1002/(SICI)1096-8652(199901)60:1<61:AID-AJH10>3.0.CO;2-L CrossRefPubMed

18.

Gaulard P, Belhadj K, Reyes F (2003) Gammadelta T-cell lymphomas. Semin Hematol 40(3):233–243 (S0037196303001379)CrossRefPubMed

19.

Schafer E, Chen A, Arceci RJ (2009) Sustained first remission in an adolescent with hepatosplenic T-cell lymphoma treated with T-cell leukemia induction, nucleoside analog-based consolidation, and early hematopoietic stem cell transplant. Pediatr Blood Cancer 53(6):1127–1129. doi:10.1002/pbc.22129 CrossRefPubMedPubMedCentral

20.

Weidmann E (2000) Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 14(6):991–997CrossRefPubMed

21.

Mittal S, Milner BJ, Johnston PW, Culligan DJ (2006) A case of hepatosplenic gamma-delta T-cell lymphoma with a transient response to fludarabine and alemtuzumab. Eur J Haematol 76(6):531–534. doi:10.1111/j.1600-0609.2006.00646.x CrossRefPubMed

22.

Jaeger G, Bauer F, Brezinschek R, Beham-Schmid C, Mannhalter C, Neumeister P (2008) Hepatosplenic gammadelta T-cell lymphoma successfully treated with a combination of alemtuzumab and cladribine. Ann Oncol 19(5):1025–1026. doi:10.1093/annonc/mdn119mdn119 CrossRefPubMed

Title: Aggressive Lymphomas Diagnosed in the Bone Marrow: Two Illustrative Cases
Authors: Rekha Bhat
Swati Pai
Kunal Das
Ashish Dixit
Publication date: 01-06-2016
Publisher: Springer India
Published in: Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2016
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-015-0520-7

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