Skip to main content
Top
Published in: The Journal of Headache and Pain 1/2018

Open Access 01-12-2018 | Research article

Aggression and its association with suicidality in migraine patients: a case-control study

Authors: Sung-Pa Park, Jong-Geun Seo

Published in: The Journal of Headache and Pain | Issue 1/2018

Login to get access

Abstract

Background

To identify aggression and its association with suicidality in migraine patients.

Methods

We enrolled 144 migraine patients who made their first visit to our headache clinic. We collected data regarding their clinical characteristics and the patients completes the Aggression Questionnaire (AQ) and other questionnaires. We also interviewed patients with the Mini International Neuropsychiatric Interview—Plus Version 5.0.0 (MINI) to identify their suicidality. The degree of aggression in migraine patients was compared to the degree of aggression in healthy controls. Major determinants for aggression and its association with suicidality were also examined.

Results

The overall AQ score and anger and hostility subscale scores were higher in migraine patients than controls. For migraine chronicity, patients with chronic migraine (CM) had a higher overall AQ score and physical aggression, anger, and hostility subscale scores than controls. On the other hand, all AQ scores in patients with episodic migraine were not different from the scores of the controls. Although several factors were associated with the overall AQ score, major determinants were anxiety (ß = 0.395, p < 0.001), headache intensity (ß = 0.180, p = 0.016), and CM (ß = − 0.165, p = 0.037). Patients who had suicidality based on the MINI showed a higher overall AQ score than patients without suicidality (p < 0.001).

Conclusions

Aggression is likely to be a common feature in CM. Comorbid aggression may help to identify suicidality in migraine patients.
Literature
1.
go back to reference Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American migraine study II. Headache 41:646–657CrossRefPubMed Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American migraine study II. Headache 41:646–657CrossRefPubMed
2.
go back to reference Minen MT, Begasse De Dhaem O, Powers S, Schwedt TJ, Lipton R, Silbersweig D (2016) Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry 87:741–749CrossRefPubMed Minen MT, Begasse De Dhaem O, Powers S, Schwedt TJ, Lipton R, Silbersweig D (2016) Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry 87:741–749CrossRefPubMed
3.
go back to reference Seo JG, Park SP (2018) Significance of fatigue in patients with migraine. J Clin Neurosci 50:69–73CrossRefPubMed Seo JG, Park SP (2018) Significance of fatigue in patients with migraine. J Clin Neurosci 50:69–73CrossRefPubMed
5.
go back to reference Lee YH, Yoon SJ, Kim A, Seo H, Ko S (2016) Health performance and challenges in Korea: a review of the global burden of disease study 2013. J Korean Med Sci 31(Suppl 2):S114–S120CrossRefPubMedPubMedCentral Lee YH, Yoon SJ, Kim A, Seo H, Ko S (2016) Health performance and challenges in Korea: a review of the global burden of disease study 2013. J Korean Med Sci 31(Suppl 2):S114–S120CrossRefPubMedPubMedCentral
8.
go back to reference Ramirez JM, Andreu JM (2006) Aggression, and some related psychological constructs (anger, hostility, and impulsivity); some comments from a research project. Neurosci Biobehav Rev 30:276–291CrossRefPubMed Ramirez JM, Andreu JM (2006) Aggression, and some related psychological constructs (anger, hostility, and impulsivity); some comments from a research project. Neurosci Biobehav Rev 30:276–291CrossRefPubMed
9.
go back to reference Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321–352CrossRefPubMed Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321–352CrossRefPubMed
11.
go back to reference Davis RE, Smitherman TA, Baskin SM (2013) Personality traits, personality disorders, and migraine: a review. Neurol Sci 34(Suppl 1):S7–S10CrossRefPubMed Davis RE, Smitherman TA, Baskin SM (2013) Personality traits, personality disorders, and migraine: a review. Neurol Sci 34(Suppl 1):S7–S10CrossRefPubMed
12.
go back to reference Silberstein S, Lipton R, Breslau N (1995) Migraine: association with personality characteristics and psychopathology. Cephalalgia 15:358–369CrossRefPubMed Silberstein S, Lipton R, Breslau N (1995) Migraine: association with personality characteristics and psychopathology. Cephalalgia 15:358–369CrossRefPubMed
13.
go back to reference Leichsenring F, Leibing E, Kruse J, New AS, Leweke F (2011) Borderline personality disorder. Lancet 377:74–84CrossRefPubMed Leichsenring F, Leibing E, Kruse J, New AS, Leweke F (2011) Borderline personality disorder. Lancet 377:74–84CrossRefPubMed
16.
17.
go back to reference Headache Classification Committee of the International Headache Society (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808CrossRef Headache Classification Committee of the International Headache Society (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808CrossRef
18.
go back to reference Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF; American Migraine Prevalence Prevention Advisory Group (2008) Cutaneous allodynia in the migraine population. Ann Neurol 63:148–158CrossRef Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF; American Migraine Prevalence Prevention Advisory Group (2008) Cutaneous allodynia in the migraine population. Ann Neurol 63:148–158CrossRef
19.
go back to reference Seo SG, Kwon SM (2002) Validation study of the Korean version of the aggression questionnaire. Korean J Clin Psychol 21:487–501 Seo SG, Kwon SM (2002) Validation study of the Korean version of the aggression questionnaire. Korean J Clin Psychol 21:487–501
20.
go back to reference Lee HS, Chung CS, Song HJ, Park HS (2000) The reliability and validity of the MIDAS (migraine disability assessment) questionnaire for Korean migraine sufferers. J Korean Neurol Assoc 18:287–291 Lee HS, Chung CS, Song HJ, Park HS (2000) The reliability and validity of the MIDAS (migraine disability assessment) questionnaire for Korean migraine sufferers. J Korean Neurol Assoc 18:287–291
23.
go back to reference Cho YW, Lee JH, Son HK, Lee SH, Shin C, Johns MW (2011) The reliability and validity of the Korean version of the Epworth sleepiness scale. Sleep Breath 15:377–384CrossRefPubMed Cho YW, Lee JH, Son HK, Lee SH, Shin C, Johns MW (2011) The reliability and validity of the Korean version of the Epworth sleepiness scale. Sleep Breath 15:377–384CrossRefPubMed
25.
go back to reference Yoo SW, Kim YS, Noh JS, Oh KS, Kim CH, Namkoong K, Chae JH, Lee GC, Jeon SI, Min KJ, Oh DJ, Koo EJ, Park HJ, Choi YH, Kim SJ (2006) Validity of Korean version of the MINI-international neuropsychiatric interview. Anxiety and Mood 2:50–55 Yoo SW, Kim YS, Noh JS, Oh KS, Kim CH, Namkoong K, Chae JH, Lee GC, Jeon SI, Min KJ, Oh DJ, Koo EJ, Park HJ, Choi YH, Kim SJ (2006) Validity of Korean version of the MINI-international neuropsychiatric interview. Anxiety and Mood 2:50–55
27.
go back to reference Bag B, Hacihasanoglu R, Tufekci FG (2005) Examination of anxiety, hostility and psychiatric disorders in patients with migraine and tension-type headache. Int J Clin Pract 59:515–521CrossRefPubMed Bag B, Hacihasanoglu R, Tufekci FG (2005) Examination of anxiety, hostility and psychiatric disorders in patients with migraine and tension-type headache. Int J Clin Pract 59:515–521CrossRefPubMed
28.
go back to reference Perozzo P, Savi L, Castelli L, Valfrè W, Lo Giudice R, Gentile S, Rainero I, Pinessi L (2005) Anger and emotional distress in patients with migraine and tension-type headache. J Headache Pain 6:392–399CrossRefPubMedPubMedCentral Perozzo P, Savi L, Castelli L, Valfrè W, Lo Giudice R, Gentile S, Rainero I, Pinessi L (2005) Anger and emotional distress in patients with migraine and tension-type headache. J Headache Pain 6:392–399CrossRefPubMedPubMedCentral
29.
go back to reference Abbate-Daga G, Fassino S, Lo Giudice R, Rainero I, Gramaglia C, Marech L, Amianto F, Gentile S, Pinessi L (2007) Anger, depression and personality dimensions in patients with migraine without aura. Psychother Psychosom 76:122–128CrossRefPubMed Abbate-Daga G, Fassino S, Lo Giudice R, Rainero I, Gramaglia C, Marech L, Amianto F, Gentile S, Pinessi L (2007) Anger, depression and personality dimensions in patients with migraine without aura. Psychother Psychosom 76:122–128CrossRefPubMed
30.
go back to reference Luerding R, Henkel K, Gaul C, Dresler T, Lindwurm A, Paelecke-Habermann Y, Leinisch E, Jürgens TP (2012) Aggressiveness in different presentations of cluster headache: results from a controlled multicentric study. 32:528–536 Luerding R, Henkel K, Gaul C, Dresler T, Lindwurm A, Paelecke-Habermann Y, Leinisch E, Jürgens TP (2012) Aggressiveness in different presentations of cluster headache: results from a controlled multicentric study. 32:528–536
34.
go back to reference Gorman JM, Kent JM, Sullivan GM, Coplan JD (2000) Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 157:493–505CrossRefPubMed Gorman JM, Kent JM, Sullivan GM, Coplan JD (2000) Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 157:493–505CrossRefPubMed
35.
go back to reference Schulte LH, Allers A, May A (2017) Hypothalamus as a mediator of chronic migraine: evidence from high-resolution fMRI. Neurology 88:2011–2016CrossRefPubMed Schulte LH, Allers A, May A (2017) Hypothalamus as a mediator of chronic migraine: evidence from high-resolution fMRI. Neurology 88:2011–2016CrossRefPubMed
36.
go back to reference Serafini G, Pompili M, Innamorati M, Gentile G, Borro M, Lamis DA, Lala N, Negro A, Simmaco M, Girardi P, Martelletti P (2012) Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation. Eur Rev Med Pharmacol Sci 16:1389–1398PubMed Serafini G, Pompili M, Innamorati M, Gentile G, Borro M, Lamis DA, Lala N, Negro A, Simmaco M, Girardi P, Martelletti P (2012) Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation. Eur Rev Med Pharmacol Sci 16:1389–1398PubMed
Metadata
Title
Aggression and its association with suicidality in migraine patients: a case-control study
Authors
Sung-Pa Park
Jong-Geun Seo
Publication date
01-12-2018
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2018
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-018-0903-x

Other articles of this Issue 1/2018

The Journal of Headache and Pain 1/2018 Go to the issue