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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2018

Open Access 01-12-2018 | Review

Migraine and cluster headache – the common link

Authors: Anne Luise Vollesen, Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Messoud Ashina, Christian Lampl, on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)

Published in: The Journal of Headache and Pain | Issue 1/2018

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Abstract

Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.
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Metadata
Title
Migraine and cluster headache – the common link
Authors
Anne Luise Vollesen
Silvia Benemei
Francesca Cortese
Alejandro Labastida-Ramírez
Francesca Marchese
Lanfranco Pellesi
Michele Romoli
Messoud Ashina
Christian Lampl
on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)
Publication date
01-12-2018
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2018
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-018-0909-4

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