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Child's Nervous System
Published in: Child's Nervous System 7-8/2003

01-08-2003 | Original Paper

Agenesis of corpus callosum: prenatal diagnosis and prognosis

Authors: Marie-Laure Moutard, Virginie Kieffer, Josué Feingold, François Kieffer, Fanny Lewin, Catherine Adamsbaum, Antoinette Gélot, Jaume Campistol i Plana, Patrick van Bogaert, Monique André, Gérard Ponsot

Published in: Child's Nervous System | Issue 7-8/2003

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Abstract

Introduction

Agenesis of corpus callosum (ACC) is commonly diagnosed prenatally. When isolated, it appears to carry a good prognosis but studies are often retrospective and follow-up short. We report a prospective study of 17 children (11 boys, 6 girls) with prenatally diagnosed isolated ACC.

Methods

Neuropsychological evaluation was performed each year and results at the ages of 2, 4, and 6 years were compared.

Results

Febrile seizures occurred in 3 patients. Median intellectual quotient (IQ) was within the normal range (80–109) and nonrelated to partial or complete ACC, sex, or febrile seizures. Lower median IQ was significantly related to low cultural status. With age, the number of children with IQ in the lower range (80–89) increased and slowness, attentional troubles, and instability appeared.

Conclusion

This study demonstrates that if outcome of isolated ACC is favorable, a long follow-up is necessary: with age, IQ in the lower range and behavioral troubles are linked to difficulties in school.
Literature
1.
Bamforth F, Bamforth S, Poskitt K, Applegarth D, Hall J (1988) Abnormalities of corpus callosum in patients with inherited metabolic diseases. Lancet 2:451
2.
Battistella PA (1993) Occurrence of Andermann syndrome out of French Canada—agenesis of the corpus callosum with neuronopathy. Neuropediatrics 24:107–110PubMed
3.
Berry-Kravis E, Israel J (1994) X-linked pachygyria and agenesis of the corpus callosum: evidence for an X-chromosome lissencephaly locus. Ann Neurol 36:229–233
4.
Blum A, André M, Droulle P, Husson S, Leheup B (1990) Prenatal diagnosis of the corpus callosum agenesis. The Nancy experience, 1982–1989. Genet Couns 38:115–126
5.
Brown GK, Brown RM, Scholem RD, Kirby DM, Dahl HH (1989) The clinical and biochemical spectrum of human pyruvate deshydrogenase complex deficiency. Annals NY Acad Sci 573:360–368
6.
Brunet O, Lézine I (1977) Echelle de développement psychomoteur de la première enfance. Etablissements d'applications psychotechniques (EAP)
7.
Casaubon LK, Melanson M, Lopes-Cendes I, Marineau C, Andermann E, Andermann F, Weissenbach J, Prevost C, Bouchard JP, Mathieu J, Rouleau GA (1996) The gene responsible for a severe form of peripheral neuropathy and agenesis of corpus callosum maps to chromosome 15q. Am J Hum Genet 58:28–34PubMed
8.
Chacko A, Koul R, Sankhla DK (2001) Corpus callosum agenesis. Saudi Med J 22:22–25PubMed
9.
De Agostini M, Dellatolas G (1988) Une épreuve simple pour évaluer la préférence manuelle chez l'enfant de 3 ans. Enfance 41:139–147
10.
D'Ercole C, Girard N, Cravello L, Boubli L, Potier A, Raybaud C, Blanc B (1998) Prenatal diagnostics of fetal corpus callosum agenesis by ultrasonography and magnetic resonance imaging. Prenat Diagn 18:247–253CrossRefPubMed
11.
Diebler K, Dulac O (1987) Malformations of the corpus callosum in pediatric neurology and neuroradiology. Springer, Berlin Heidelberg New York, pp 1–4
12.
Dobyns WB (1996) Absence makes the search much longer. Am J Hum Genet 58:7–16PubMed
13.
Doffe L, Adamsbaum C, Rolland Y, Robain O, Ponsot G, Kalifa G (1996) Agénésie du corps calleux et kyste inter hémisphérique paramédian. J Radiol 77:427–43PubMed
14.
Dominguez R, Aguirre Vila-Coro A, Slopis JM, Bohan TP (1991) Brain and ocular abnormalities in infants with in utero exposure to cocaine and other street drugs. Am J Dis Child 145:688–695PubMed
15.
Fischer M, Ryan SB, Dobyns WB (1992) Mechanisms of hemispheric transfer and patterns of cognitive functions in acallosal patients of normal intelligence. Arch Neurol 49:271–277PubMed
16.
Gelot A, Esperandieu O, Pompidou A (1998) Histogénèse du corps calleux. Neurochirurgie 44 [Suppl 1]:61–73
17.
Goodyear PW, Bannister CM, Russell S, Rimmer S (2001) Outcome in prenatally diagnosed fetal agenesis of corpus callosum. Fetal Diagn Ther 16:139–145CrossRefPubMed
18.
Gupta JK, Lilford RJ (1995) Assessment and management of fetal agenesis of the corpus callosum. Prenatal Diagn 15:301–312PubMed
19.
Hirayama K, Hoshino Y, Kumashiro H, Yamamoto T (1994) Reverse Shapiro's syndrome: a case of agenesis of the corpus callosum associated with periodic hyperthermia. Arch Neurol 51:494–496PubMed
20.
Jacobson LS, Servos P, Goodale MA, Lassonde M (1994) Control of proximal and distal components of prehension in callosal agenesis. Brain 117:1107–1113PubMed
21.
Jeret JS, Serur D, Wiesniewski KE, Lubin RA (1987) Clinicopathological findings associated with agenesis of the corpus callosum. Brain Dev 9:255–264PubMed
22.
Kaufmann AS, Kaufmann NL (1983) Batterie pour l'examen psychologique de l'enfant. American guidance service (version française 1993 par ECPA)
23.
Lair-Milan F, Gelot A, Baron JM, Lewin F, André C, Adamsbaum C (1997) IRM encéphalique antenatale. Etude rétrospective à propos de 34 examens. J Radiol 78:499–505
24.
Lemesle M, Giroud M, Madinier G, Martin D, Baudouin N, Binnert D, Dumas R (1997) Agénésie du corps calleux: les modes de révélation chez l'adulte. Rev Neurol (Paris) 153:256–261
25.
Lindhout D, Omtzigt JG, Cornel MC (1992) Spectrum of neural tube defects in 34 infants prenatally exposed to antiepileptic drugs. Neurology 42:11–18PubMed
26.
Malinger G, Lev D, Lerman-Sagie T (2002) Is fetal magnetic resonance imaging superior to sonography for detection of brain anomalies? Ultrasound Obstet Gynecol 20:317–321
27.
Philip N, Chabrol B, Lethel V (1998) Génétique de l'agénésie du corps calleux. Neurochirurgie 44 [Suppl 1]:99–101
28.
Pilu G, Sandri F, Perolo A, Pittalis MC, Grisolia G, Cocchi G, Foschini MP, Salvioli GP, Bovicelli L (1993) Sonography of fetal agenesis of the corpus callosum: a survey of 35 cases. Ultrasound Obstet Gynecol 3:318–329CrossRefPubMed
29.
Shevell MI, Matthews PM, Scriver CR, Brown RM, Otero LJ, Legris M, Brown GK, Arnold DL (1994) Cerebral dysgenesis and lactic acidemia: an MRI/MRS phenotype associated with pyruvate deshydrogenase deficiency. Pediatr Neurol 11:224–229CrossRefPubMed
30.
Tiffin J (1961) Examiner manual for the Purdue Pegboard. Purdue research foundation (French version by ECPA 1961)
31.
Vergani P, Ghidini A, Strobelt N, Locatelli A, Mariani S, Bertalero C, Cavallone M (1994) Prognostic indicators in the prenatal diagnosis of agenesis of the corpus callosum. Am J Obstet Gynecol 170:753–758PubMed
32.
Wechsler D (1989) Manual for the Wechsler preschool and primary scale of intelligence revised. The psychological corporation (French version 1995 by ECPA)
Metadata
Title
Agenesis of corpus callosum: prenatal diagnosis and prognosis
Authors
Marie-Laure Moutard
Virginie Kieffer
Josué Feingold
François Kieffer
Fanny Lewin
Catherine Adamsbaum
Antoinette Gélot
Jaume Campistol i Plana
Patrick van Bogaert
Monique André
Gérard Ponsot
Publication date
01-08-2003
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 7-8/2003
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-003-0781-6

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