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Child's Nervous System

Published in:

01-08-2003 | Original Paper

Prenatal screening: invasive diagnostic approaches

Authors: Claude d'Ercole, Raha Shojai, Raoul Desbriere, Cécile Chau, Florence Bretelle, Laurence Piéchon, Léon Boubli

Published in: Child's Nervous System | Issue 7-8/2003

Abstract

Introduction

Fetal invasive procedures provide ovular samples that are helpful in establishing diagnosis, etiology, and prognosis when ultrasonography and MRI show a central nervous system (CNS) anomaly or when the fetus is at high risk of such pathology.

Procedures

Invasive procedure techniques are amniocentesis, fetal blood sampling (FBS), and chorionic villous sampling (CVS). They provide material for fetal DNA, biochemical analysis, or identification of various infectious agents.

Complications

The main complications are miscarriage and premature delivery. Counseling the parents about the risks and benefits of these procedures is therefore mandatory.

Discussion

Amniocentesis may be performed as early as 15 weeks' gestation and is the most widely used invasive technique. FBS is performed after 18 to 20 weeks of pregnancy and CVS may be carried out after 11 weeks. Indications for invasive techniques include DNA and cytogenetic analysis, diagnosis of neural tube defects, identification of infectious agents (toxoplasmosis, cytomegalovirus, rubella, and varicella), and etiology of intracerebral hemorrhage (fetal platelets and coagulation factors).

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Title: Prenatal screening: invasive diagnostic approaches
Authors: Claude d'Ercole
Raha Shojai
Raoul Desbriere
Cécile Chau
Florence Bretelle
Laurence Piéchon
Léon Boubli
Publication date: 01-08-2003
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 7-8/2003
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-003-0788-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prenatal screening: invasive diagnostic approaches

Abstract

Introduction

Procedures

Complications

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Procedures

Complications

Discussion

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