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01-11-2005 | Neuro

Age-related signal intensity changes in the corpus callosum: assessment with three orthogonal FLAIR images

Authors: Akira Yamamoto, Yukio Miki, Hidekazu Tomimoto, Mitsunori Kanagaki, Takahiro Takahashi, Yasutaka Fushimi, Junya Konishi, Tabassum Laz Haque, Kaori Togashi

Published in: European Radiology | Issue 11/2005

Abstract

The presence of age-related hyperintensities of the corpus callosum has not been thoroughly evaluated. Fifty-two patients of 50 years of age or older (mean, 71 years; range, 50–87 years) were included in this study. Fluid-attenuated inversion recovery images were obtained in three orthogonal planes. Periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) were graded according to Fazekas’ rating scale. Correlations between the presence of hyperintensities in the corpus callosum and age, and the grade of PVH and DWMH were statistically analyzed. PVH was categorized as grade 0 (n=4), grade 1 (n=28), grade 2 (n=10), or grade 3 (n=10). DWMH was categorized as grade 0 (n=4), grade 1 (n=25), grade 2 (n=8), or grade 3 (n=15). Hyperintensity was considered present in the corpus callosum in 31 of the 52 patients (60%). In these 31 patients, PVH was categorized as grade 1 (n=16), grade 2 (n=7), or grade 3 (n=8), while DWMH was categorized as grade 0 (n=1), grade 1 (n=10), grade 2 (n=7), or grade 3 (n=13). The presence of callosal hyperintensities was significantly correlated with age (p=0.001), and with PVH (p=0.04) and DWMH grades (p=0.004). Hyperintensities may be present in the corpus callosum with aging, and are correlated with PVH and DWMH.

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Title: Age-related signal intensity changes in the corpus callosum: assessment with three orthogonal FLAIR images
Authors: Akira Yamamoto
Yukio Miki
Hidekazu Tomimoto
Mitsunori Kanagaki
Takahiro Takahashi
Yasutaka Fushimi
Junya Konishi
Tabassum Laz Haque
Kaori Togashi
Publication date: 01-11-2005
Publisher: Springer-Verlag
Published in: European Radiology / Issue 11/2005
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-005-2759-0

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Age-related signal intensity changes in the corpus callosum: assessment with three orthogonal FLAIR images

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