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Open Access 01-12-2021 | Mood Disorders | Research article

Antenatal depressive symptoms and adverse perinatal outcomes

Authors: Despina Pampaka, Stefania I. Papatheodorou, Mohammad AlSeaidan, Rihab Al Wotayan, Rosalind J. Wright, Julie E. Buring, Douglas W. Dockery, Costas A. Christophi

Published in: BMC Pregnancy and Childbirth | Issue 1/2021

Abstract

Background

The association of antenatal depression with adverse pregnancy, birth, and postnatal outcomes has been an item of scientific interest over the last decades. However, the evidence that exists is controversial or limited. We previously found that one in five women in Kuwait experience antenatal depressive symptoms. Therefore, the aim of this study was to examine whether antenatal depressive symptoms are associated with preterm birth (PTB), small for gestational age (SGA), or large for gestational age (LGA) babies in this population.

Methods

This was a secondary analysis based on data collected in the Transgenerational Assessment of Children’s Environmental Risk (TRACER) Study that was conducted in Kuwait. Logistic regression analysis was used to examine whether antenatal depressive symptoms assessed using the Edinburgh Depression Scale (EDS) were associated with preterm birth, small for gestational age, and large for gestational age babies.

Results

A total of 1694 women had complete information about the outcomes of interest. Women with depressive symptoms in pregnancy had increased, albeit non-significant, odds of having PTB (OR = 1.41; 95%CI: 0.81, 2.45), SGA babies (OR = 1.26; 0.80, 1.98), or LGA babies (OR = 1.27; 0.90, 1.79). Antenatal depressive symptoms had similar increased odds for the three outcomes even after adjusting for several covariates though none of these reached statistical significance.

Conclusions

In the present study, the depressive symptoms in pregnancy did not predict adverse birth outcomes, such as PTB, SGA, and LGA, which adds to the currently non-conclusive literature. However, further research is needed to examine these associations, as the available evidence is quite limited.

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Title: Antenatal depressive symptoms and adverse perinatal outcomes
Authors: Despina Pampaka
Stefania I. Papatheodorou
Mohammad AlSeaidan
Rihab Al Wotayan
Rosalind J. Wright
Julie E. Buring
Douglas W. Dockery
Costas A. Christophi
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Mood Disorders
Premature Birth
Affective Disorder
Published in: BMC Pregnancy and Childbirth / Issue 1/2021
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/s12884-021-03783-9

2024 ASCO Annual Meeting

Springer Medicine

Antenatal depressive symptoms and adverse perinatal outcomes

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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