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Published in: BMC Public Health 1/2019

Open Access 01-12-2019 | Mood Disorders | Research article

Effects of psychosocial interventions on children affected by parental HIV/AIDS: a meta-analysis on depression and anxiety

Authors: Peilian Chi, Shan Zhao, Chen Zhang, Xiaoming Li, Yan Guo, Xiuyun Lin, Hongfei Du

Published in: BMC Public Health | Issue 1/2019

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Abstract

Background

Children orphaned by parental AIDS or those of parents with HIV infection demonstrate many negative mental health outcomes. Different types of psychosocial interventions have been conducted to improve the psychological well-being of these children. The efficacy of these psychosocial interventions has been reviewed and synthesized recently (Skeena et al., Vulnerable Child Youth Stud 12:91-116, 2017), but not quantified.

Method

This study therefore adopted meta-analytic approach to quantify the efficacy of the existing psychosocial interventions on depressive and anxiety symptoms in children affected by parental HIV/AIDS. Eight intervention studies—four randomized controlled trials (RCT) and four pre–post intervention trials—were included.

Result

In general, psychosocial interventions could effectively reduce anxiety or depressive symptoms in children of parents with HIV/AIDS. The overall intervention effect size (Cohen’s d) was 1.298 and 1.100 for depressive and anxiety symptoms, respectively. Publication bias and exploratory moderating effects of study design (RCT vs. pre–post intervention trials), study location, and intervention levels were also analyzed.

Conclusion

Future studies reporting the detailed outcome data, which could be used for research integration, are warranted. Further research should also focus on the implementation of evidence-based interventions sensitive to the target population in a developmentally appropriate manner.
Literature
1.
go back to reference Akwara PA, Noubary B, Lim Ah Ken P, Johnson K, Yates R, Winfrey W, et al. Who is the vulnerable child? Using survey data to identify children at risk in the era of HIV and AIDS. AIDS Care. 2010;22(9):1066–85.CrossRefPubMed Akwara PA, Noubary B, Lim Ah Ken P, Johnson K, Yates R, Winfrey W, et al. Who is the vulnerable child? Using survey data to identify children at risk in the era of HIV and AIDS. AIDS Care. 2010;22(9):1066–85.CrossRefPubMed
2.
go back to reference Chi PL, Li XM. Impact of parental HIV/AIDS on Children's psychological well-being: a systematic review of global literature. AIDS Behav. 2013;17(7):2554–74.CrossRefPubMedPubMedCentral Chi PL, Li XM. Impact of parental HIV/AIDS on Children's psychological well-being: a systematic review of global literature. AIDS Behav. 2013;17(7):2554–74.CrossRefPubMedPubMedCentral
3.
go back to reference Cluver LD, Orkin M, Gardner F, Boyes ME. Persisting mental health problems among AIDS-orphaned children in South Africa. J Child Psychol Psychiatry. 2012;53(4):363–70.CrossRefPubMed Cluver LD, Orkin M, Gardner F, Boyes ME. Persisting mental health problems among AIDS-orphaned children in South Africa. J Child Psychol Psychiatry. 2012;53(4):363–70.CrossRefPubMed
4.
go back to reference Mason S, Sultzman VO. Stigma as experienced by children of HIV-positive parents: a narrative review. Aids Care-Psychol Socio-Med Asp Aids-Hiv. 2019;31(9):1049–60. Mason S, Sultzman VO. Stigma as experienced by children of HIV-positive parents: a narrative review. Aids Care-Psychol Socio-Med Asp Aids-Hiv. 2019;31(9):1049–60.
5.
go back to reference Gregson CL, Hartley A, Majonga E, McHugh G, Crabtree N, Rukuni R, et al. Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe. Bone. 2019;125:96–102.CrossRefPubMedPubMedCentral Gregson CL, Hartley A, Majonga E, McHugh G, Crabtree N, Rukuni R, et al. Older age at initiation of antiretroviral therapy predicts low bone mineral density in children with perinatally-infected HIV in Zimbabwe. Bone. 2019;125:96–102.CrossRefPubMedPubMedCentral
6.
go back to reference Atwine B, Cantor-Graae E, Bajunirwe F. Psychological distress among AIDS orphans in rural Uganda. Soc Sci Med. 2005;61(3):555–64.CrossRefPubMed Atwine B, Cantor-Graae E, Bajunirwe F. Psychological distress among AIDS orphans in rural Uganda. Soc Sci Med. 2005;61(3):555–64.CrossRefPubMed
7.
go back to reference Forsyth BC, Damour L, Nagler S, Adnopoz J. The psychological effects of parental human immunodeficiency virus infection on uninfected children. Arch Pediatr Adolesc Med. 1996;150(10):1015–20.CrossRefPubMed Forsyth BC, Damour L, Nagler S, Adnopoz J. The psychological effects of parental human immunodeficiency virus infection on uninfected children. Arch Pediatr Adolesc Med. 1996;150(10):1015–20.CrossRefPubMed
8.
go back to reference Sun S, Li L, Ji G, Lin C, Semaan A. Child behaviour and parenting in HIV/AIDS-affected families in China. Vulnerable Child Youth Stud. 2008;3(3):192–202.CrossRefPubMedPubMedCentral Sun S, Li L, Ji G, Lin C, Semaan A. Child behaviour and parenting in HIV/AIDS-affected families in China. Vulnerable Child Youth Stud. 2008;3(3):192–202.CrossRefPubMedPubMedCentral
9.
go back to reference Esposito S, Musetti L, Musetti MC, Tornaghi R, Corbella S, Massironi E, et al. Behavioral and psychological disorders in uninfected children aged 6 to 11 years born to human immunodeficiency virus-seropositive mothers. J Dev Behav Pediatr. 1999;20(6):411–7.CrossRefPubMed Esposito S, Musetti L, Musetti MC, Tornaghi R, Corbella S, Massironi E, et al. Behavioral and psychological disorders in uninfected children aged 6 to 11 years born to human immunodeficiency virus-seropositive mothers. J Dev Behav Pediatr. 1999;20(6):411–7.CrossRefPubMed
10.
go back to reference Ji G, Li L, Ding Y, Xiao Y, Tian J. Parents living with HIV and children's stress and delinquent behaviors in China. Vulnerable Child Youth Stud. 2012;7(3):249–59.CrossRefPubMedPubMedCentral Ji G, Li L, Ding Y, Xiao Y, Tian J. Parents living with HIV and children's stress and delinquent behaviors in China. Vulnerable Child Youth Stud. 2012;7(3):249–59.CrossRefPubMedPubMedCentral
11.
go back to reference Cluver LD, Frances G, Don O. Effects of stigma on the mental health of adolescents orphaned by AIDS. J Adolesc Health. 2008;42(4):410–7.CrossRefPubMed Cluver LD, Frances G, Don O. Effects of stigma on the mental health of adolescents orphaned by AIDS. J Adolesc Health. 2008;42(4):410–7.CrossRefPubMed
12.
go back to reference Eloff I, Finestone M, Makin JD, Boeving-Allen A, Visser M, Ebersohn L, et al. A randomized clinical trial of an intervention to promote resilience in young children of HIV-positive mothers in South Africa. Aids. 2014;28:S347–S57.CrossRefPubMed Eloff I, Finestone M, Makin JD, Boeving-Allen A, Visser M, Ebersohn L, et al. A randomized clinical trial of an intervention to promote resilience in young children of HIV-positive mothers in South Africa. Aids. 2014;28:S347–S57.CrossRefPubMed
13.
go back to reference Skeena SA, Sherr L, Croomed N, Gandhi N, Roberts KJ, Macedo A, et al. Interventions to improve psychosocial well-being for children affected by HIV and AIDS: a systematic review. Vulnerable Child Youth Stud. 2017;12(2):91–116.CrossRef Skeena SA, Sherr L, Croomed N, Gandhi N, Roberts KJ, Macedo A, et al. Interventions to improve psychosocial well-being for children affected by HIV and AIDS: a systematic review. Vulnerable Child Youth Stud. 2017;12(2):91–116.CrossRef
14.
go back to reference Rotheram-Borus MJ, Stein JA, Lin YY. Impact of parent death and an intervention on the adjustment of adolescents whose parents have HIV/AIDS. J Consult Clin Psychol. 2001;69(5):763–73.CrossRefPubMed Rotheram-Borus MJ, Stein JA, Lin YY. Impact of parent death and an intervention on the adjustment of adolescents whose parents have HIV/AIDS. J Consult Clin Psychol. 2001;69(5):763–73.CrossRefPubMed
15.
go back to reference Sherr L, Croome N, Bradshaw K, Castaneda KP. A systematic review examining whether interventions are effective in reducing cognitive delay in children infected and affected with HIV. Aids Care-Psychol Socio-Med Asp Aids-Hiv. 2014;26:S70–S7. Sherr L, Croome N, Bradshaw K, Castaneda KP. A systematic review examining whether interventions are effective in reducing cognitive delay in children infected and affected with HIV. Aids Care-Psychol Socio-Med Asp Aids-Hiv. 2014;26:S70–S7.
16.
go back to reference Kumakech E, Cantor-Graae E, Maling S, Bajunirwe F. Peer-group support intervention improves the psychosocial well-being of AIDS orphans: cluster randomized trial. Soc Sci Med. 2009;68(6):1038–43.CrossRefPubMed Kumakech E, Cantor-Graae E, Maling S, Bajunirwe F. Peer-group support intervention improves the psychosocial well-being of AIDS orphans: cluster randomized trial. Soc Sci Med. 2009;68(6):1038–43.CrossRefPubMed
17.
go back to reference Carlson M, Brennan RT, Earls F. Enhancing adolescent self-efficacy and collective efficacy through public engagement around HIV/AIDS competence: a multilevel, cluster randomized-controlled trial. Soc Sci Med. 2012;75(6):1078–87.CrossRefPubMed Carlson M, Brennan RT, Earls F. Enhancing adolescent self-efficacy and collective efficacy through public engagement around HIV/AIDS competence: a multilevel, cluster randomized-controlled trial. Soc Sci Med. 2012;75(6):1078–87.CrossRefPubMed
18.
go back to reference Balfour L, Farrar T, Mcgilvray M, Wilson D, Tasca GA, Spaans JN, et al. HIV prevention in action on the football field: the WhizzKids United program in South Africa. AIDS Behav. 2013;17(6):2045–52.CrossRefPubMed Balfour L, Farrar T, Mcgilvray M, Wilson D, Tasca GA, Spaans JN, et al. HIV prevention in action on the football field: the WhizzKids United program in South Africa. AIDS Behav. 2013;17(6):2045–52.CrossRefPubMed
19.
go back to reference Hallfors D, Cho H, Rusakaniko S, Iritani B, Mapfumo J, Halpern C. Supporting adolescent orphan girls to stay in school as HIV risk prevention: evidence from a randomized controlled trial in Zimbabwe. Am J Public Health. 2011;101(6):1082.CrossRefPubMedPubMedCentral Hallfors D, Cho H, Rusakaniko S, Iritani B, Mapfumo J, Halpern C. Supporting adolescent orphan girls to stay in school as HIV risk prevention: evidence from a randomized controlled trial in Zimbabwe. Am J Public Health. 2011;101(6):1082.CrossRefPubMedPubMedCentral
20.
go back to reference Baird S, Chirwa E, McIntosh C, Özler B. The short-term impacts of a schooling conditional cash transfer program on the sexual behavior of young women. Health Econ. 2010;19(S1):55–68.CrossRefPubMed Baird S, Chirwa E, McIntosh C, Özler B. The short-term impacts of a schooling conditional cash transfer program on the sexual behavior of young women. Health Econ. 2010;19(S1):55–68.CrossRefPubMed
21.
go back to reference Ssewamala FM, Han CK, Neilands TB. Asset ownership and health and mental health functioning among AIDS-orphaned adolescents: findings from a randomized clinical trial in rural Uganda ☆. Soc Sci Med. 2009;69(2):191–8.CrossRefPubMedPubMedCentral Ssewamala FM, Han CK, Neilands TB. Asset ownership and health and mental health functioning among AIDS-orphaned adolescents: findings from a randomized clinical trial in rural Uganda ☆. Soc Sci Med. 2009;69(2):191–8.CrossRefPubMedPubMedCentral
22.
go back to reference Robertson L, Mushati P, Eaton JW, Dumba L, Mavise G, Makoni J, et al. Effects of unconditional and conditional cash transfers on child health and development in Zimbabwe: a cluster-randomised trial. Lancet (London, England). 2013;381(9874):1283–92.CrossRef Robertson L, Mushati P, Eaton JW, Dumba L, Mavise G, Makoni J, et al. Effects of unconditional and conditional cash transfers on child health and development in Zimbabwe: a cluster-randomised trial. Lancet (London, England). 2013;381(9874):1283–92.CrossRef
23.
go back to reference Ssewamala FM, Neilands TB, Jane W, Leyla I. The impact of a comprehensive microfinance intervention on depression levels of AIDS-orphaned children in Uganda. J Adolesc Health. 2012;50(4):346–52.CrossRefPubMed Ssewamala FM, Neilands TB, Jane W, Leyla I. The impact of a comprehensive microfinance intervention on depression levels of AIDS-orphaned children in Uganda. J Adolesc Health. 2012;50(4):346–52.CrossRefPubMed
24.
go back to reference Thurman TR, Jarabi B, Rice J. Caring for the caregiver: evaluation of support groups for guardians of orphans and vulnerable children in Kenya. Aids Care-Psychol Socio-Med Asp Aids-Hiv. 2012;24(7):811–9. Thurman TR, Jarabi B, Rice J. Caring for the caregiver: evaluation of support groups for guardians of orphans and vulnerable children in Kenya. Aids Care-Psychol Socio-Med Asp Aids-Hiv. 2012;24(7):811–9.
25.
go back to reference Mueller CM, Dweck CS. Praise for intelligence can undermine children’s motivation and performance. J Pers Soc Psychol. 1998;75(1):33–52.CrossRefPubMed Mueller CM, Dweck CS. Praise for intelligence can undermine children’s motivation and performance. J Pers Soc Psychol. 1998;75(1):33–52.CrossRefPubMed
26.
go back to reference Hernandez-Reif M, Shor-Posner G, Baez J, Soto S, Mendoza R, Castillo R, et al. Dominican children with HIV not receiving Antiretrovirals: massage therapy influences their behavior and development. Evid Based Complement Alternat Med. 2008;5(3):345–54.CrossRefPubMed Hernandez-Reif M, Shor-Posner G, Baez J, Soto S, Mendoza R, Castillo R, et al. Dominican children with HIV not receiving Antiretrovirals: massage therapy influences their behavior and development. Evid Based Complement Alternat Med. 2008;5(3):345–54.CrossRefPubMed
27.
go back to reference Bernardo ABI, Estrellado AF. Measuring Hope in the Philippines: validating the short version of the locus-of-Hope scale in Filipino. Soc Indic Res. 2014;119(3):1649–61.CrossRef Bernardo ABI, Estrellado AF. Measuring Hope in the Philippines: validating the short version of the locus-of-Hope scale in Filipino. Soc Indic Res. 2014;119(3):1649–61.CrossRef
28.
go back to reference Bell CC, Bhana A, Petersen I, McKay MM, Gibbons R, Bannon W, et al. Building protective factors to offset sexually risky behaviors among black youths: a randomized control trial. J Natl Med Assoc. 2008;100(8):936–44.CrossRefPubMed Bell CC, Bhana A, Petersen I, McKay MM, Gibbons R, Bannon W, et al. Building protective factors to offset sexually risky behaviors among black youths: a randomized control trial. J Natl Med Assoc. 2008;100(8):936–44.CrossRefPubMed
29.
go back to reference Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions; 2011. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions; 2011.
30.
go back to reference Murphy DA, Marelich WD, Graham J, Payne DL. Children affected by maternal HIV/AIDS: feasibility and acceptability trial of the children united with buddies (CUB) intervention. Clin Child Psychol Psychiatry. 2015;20(1):117–33.CrossRefPubMed Murphy DA, Marelich WD, Graham J, Payne DL. Children affected by maternal HIV/AIDS: feasibility and acceptability trial of the children united with buddies (CUB) intervention. Clin Child Psychol Psychiatry. 2015;20(1):117–33.CrossRefPubMed
31.
go back to reference Lin X, Fang X, Chi P, Li X, Chen W, Heath MA. Grief-processing-based psychological intervention for children orphaned by AIDS in Central China: a pilot study. Sch Psychol Int. 2014;35(6):609–26.CrossRef Lin X, Fang X, Chi P, Li X, Chen W, Heath MA. Grief-processing-based psychological intervention for children orphaned by AIDS in Central China: a pilot study. Sch Psychol Int. 2014;35(6):609–26.CrossRef
32.
go back to reference Rochat TJ, Arteche AX, Stein A, Mkwanazi N, Bland RM. Maternal HIV disclosure to young HIV-uninfected children: an evaluation of a family-centred intervention in South Africa (vol 28, pg 5331, 2014). Aids. 2014;28(17):2641.CrossRef Rochat TJ, Arteche AX, Stein A, Mkwanazi N, Bland RM. Maternal HIV disclosure to young HIV-uninfected children: an evaluation of a family-centred intervention in South Africa (vol 28, pg 5331, 2014). Aids. 2014;28(17):2641.CrossRef
33.
go back to reference Keypour M, Arman S, Reza MM. The effectiveness of cognitive behavioral stress management training on mental health, social interaction and family function in adolescents of families with one human immunodeficiency virus (HIV) positive member*. J Res Med Sci. 2011;16:741–9.PubMedPubMedCentral Keypour M, Arman S, Reza MM. The effectiveness of cognitive behavioral stress management training on mental health, social interaction and family function in adolescents of families with one human immunodeficiency virus (HIV) positive member*. J Res Med Sci. 2011;16:741–9.PubMedPubMedCentral
34.
go back to reference Kaufman JA, Zeng W, Wang L, Zhang Y. Community-based mental health counseling for children orphaned by AIDS in China. AIDS Care. 2013;25(4):430–7.CrossRefPubMed Kaufman JA, Zeng W, Wang L, Zhang Y. Community-based mental health counseling for children orphaned by AIDS in China. AIDS Care. 2013;25(4):430–7.CrossRefPubMed
35.
go back to reference O'Donnell K, Dorsey S, Gong W, Ostermann J, Whetten R, Cohen JA, et al. Treating maladaptive grief and posttraumatic stress symptoms in orphaned children in Tanzania: group-based trauma-focused cognitive-behavioral therapy. J Trauma Stress. 2014;27(6):664–71.CrossRefPubMedPubMedCentral O'Donnell K, Dorsey S, Gong W, Ostermann J, Whetten R, Cohen JA, et al. Treating maladaptive grief and posttraumatic stress symptoms in orphaned children in Tanzania: group-based trauma-focused cognitive-behavioral therapy. J Trauma Stress. 2014;27(6):664–71.CrossRefPubMedPubMedCentral
36.
go back to reference Cohen J. Statistical power ANALYSIS for the Behavioral sciences. SERBIULA (sistema Librum 20). 2nd ed; 1988. Cohen J. Statistical power ANALYSIS for the Behavioral sciences. SERBIULA (sistema Librum 20). 2nd ed; 1988.
37.
38.
go back to reference Ellis PD. The essential guide to effect sizes: Statistical power, meta-analysis, and the interpretation of research results; 2010.CrossRef Ellis PD. The essential guide to effect sizes: Statistical power, meta-analysis, and the interpretation of research results; 2010.CrossRef
39.
go back to reference Melby-Lervag M, Redick TS, Hulme C. Working memory training does not improve performance on measures of intelligence or other measures of "far transfer": evidence from a meta-analytic review. Perspect Psychol Sci. 2016;11(4):512–34.CrossRefPubMedPubMedCentral Melby-Lervag M, Redick TS, Hulme C. Working memory training does not improve performance on measures of intelligence or other measures of "far transfer": evidence from a meta-analytic review. Perspect Psychol Sci. 2016;11(4):512–34.CrossRefPubMedPubMedCentral
40.
go back to reference Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J. 2003;327(7414):557–60.CrossRef Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J. 2003;327(7414):557–60.CrossRef
41.
go back to reference Egger M. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;316(7129):469–71. Egger M. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;316(7129):469–71.
42.
go back to reference Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed
45.
go back to reference Mueller CM. Praise for intelligence can undermine children's motivation and performance; 1998. Mueller CM. Praise for intelligence can undermine children's motivation and performance; 1998.
46.
go back to reference King E, De Silva M, Stein A, Patel V. Interventions for improving the psychosocial well-being of children affected by HIV and AIDS. Cochrane Database Syst Rev. 2009;2(2):CD006733. King E, De Silva M, Stein A, Patel V. Interventions for improving the psychosocial well-being of children affected by HIV and AIDS. Cochrane Database Syst Rev. 2009;2(2):CD006733.
47.
go back to reference Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010;63(8):e1–37.CrossRefPubMed Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010;63(8):e1–37.CrossRefPubMed
Metadata
Title
Effects of psychosocial interventions on children affected by parental HIV/AIDS: a meta-analysis on depression and anxiety
Authors
Peilian Chi
Shan Zhao
Chen Zhang
Xiaoming Li
Yan Guo
Xiuyun Lin
Hongfei Du
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2019
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-019-7806-x

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