Skip to main content
Top
Published in: Pediatric Rheumatology 1/2021

01-12-2021 | Mood Disorders | Research article

Suicidal risk and resilience in juvenile fibromyalgia syndrome: a cross-sectional cohort study

Authors: Sabrina Gmuca, Maitry Sonagra, Rui Xiao, Kimberly S. Miller, Nina H. Thomas, Jami F. Young, Pamela F. Weiss, David D. Sherry, Jeffrey S. Gerber

Published in: Pediatric Rheumatology | Issue 1/2021

Login to get access

Abstract

Background

To characterize suicidality among youth with juvenile fibromyalgia syndrome (JFMS) receiving treatment from pediatric rheumatologists at a tertiary care center in order to determine the prevalence of suicidality in JFMS and to explore risk factors for persistent suicidal ideation.

Methods

We performed a cross-sectional cohort study of children 12–17 years old with JFMS seen in a specialty pediatric rheumatology pain clinic from 7/2017–9/2019. All subjects completed patient-reported outcomes measures, complemented by retrospective chart review. Subjects who endorsed item 8 on the Children’s Depression Inventory, 2nd Edition (CDI-2) were categorized as endorsing suicidal ideation. We assessed for differences between the suicidal and non-suicidal patients using Wilcoxon-rank sum test. Logistic regression modeling was performed to identify psychosocial factors associated with suicidality.

Results

Of the 31 subjects, more than one-quarter endorsed suicidality. Nearly 90% of teens with suicidal ideation were established in outpatient counseling. In bivariate analyses, suicidality was associated with lower resilience and greater depression and anxiety (all p < 0.05). Pain intensity trended towards a statistically significant positive association (OR: 1.16 [0.99–1.37]; p = 0.06). Lower resilience was independently associated with suicidality (OR: 0.90 [95% CI: 0.82–0.98]; p < 0.02).

Conclusions

Suicidality was prevalent among youth with JFMS and persistent despite concurrent receipt of mental health services. Higher patient-level resilience was independently associated with a reduced odds of suicidality. Future work should examine the role of resilience training on reducing psychological distress and mitigating the risk of suicidality in JFMS.
Literature
1.
go back to reference Calandre EP, Navajas-Rojas MA, Ballesteros J, Garcia-Carrillo J, Garcia-Leiva JM, Rico-Villademoros F. Suicidal ideation in patients with fibromyalgia: a cross-sectional study. Pain Pract. 2015;15(2):168–74.PubMedCrossRef Calandre EP, Navajas-Rojas MA, Ballesteros J, Garcia-Carrillo J, Garcia-Leiva JM, Rico-Villademoros F. Suicidal ideation in patients with fibromyalgia: a cross-sectional study. Pain Pract. 2015;15(2):168–74.PubMedCrossRef
2.
go back to reference Jimenez-Rodriguez I, Garcia-Leiva JM, Jimenez-Rodriguez BM, Condes-Moreno E, Rico-Villademoros F, Calandre EP. Suicidal ideation and the risk of suicide in patients with fibromyalgia: a comparison with non-pain controls and patients suffering from low-back pain. Neuropsychiatr Dis Treat. 2014;10:625–30.PubMedPubMedCentral Jimenez-Rodriguez I, Garcia-Leiva JM, Jimenez-Rodriguez BM, Condes-Moreno E, Rico-Villademoros F, Calandre EP. Suicidal ideation and the risk of suicide in patients with fibromyalgia: a comparison with non-pain controls and patients suffering from low-back pain. Neuropsychiatr Dis Treat. 2014;10:625–30.PubMedPubMedCentral
3.
go back to reference Kanzler KE, Bryan CJ, McGeary DD, Morrow CE. Suicidal ideation and perceived burdensomeness in patients with chronic pain. Pain Pract. 2012;12(8):602–9.PubMedCrossRef Kanzler KE, Bryan CJ, McGeary DD, Morrow CE. Suicidal ideation and perceived burdensomeness in patients with chronic pain. Pain Pract. 2012;12(8):602–9.PubMedCrossRef
4.
go back to reference Lafuente-Castro CP, Ordonez-Carrasco JL, Garcia-Leiva JM, Salgueiro-Macho M, Calandre EP. Perceived burdensomeness, thwarted belongingness and suicidal ideation in patients with fibromyalgia and healthy subjects: a cross-sectional study. Rheumatol Int. 2018;38(8):1479–86.PubMedCrossRef Lafuente-Castro CP, Ordonez-Carrasco JL, Garcia-Leiva JM, Salgueiro-Macho M, Calandre EP. Perceived burdensomeness, thwarted belongingness and suicidal ideation in patients with fibromyalgia and healthy subjects: a cross-sectional study. Rheumatol Int. 2018;38(8):1479–86.PubMedCrossRef
5.
go back to reference Trinanes Y, Gonzalez-Villar A, Gomez-Perretta C, Carrillo-de-la-Pena MT. Suicidality in chronic pain: predictors of suicidal ideation in fibromyalgia. Pain Pract. 2015;15(4):323–32.PubMedCrossRef Trinanes Y, Gonzalez-Villar A, Gomez-Perretta C, Carrillo-de-la-Pena MT. Suicidality in chronic pain: predictors of suicidal ideation in fibromyalgia. Pain Pract. 2015;15(4):323–32.PubMedCrossRef
6.
go back to reference Wolfe F, Hassett AL, Walitt B, Michaud K. Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years. Arthritis Care Res. 2011;63(1):94–101.CrossRef Wolfe F, Hassett AL, Walitt B, Michaud K. Mortality in fibromyalgia: a study of 8,186 patients over thirty-five years. Arthritis Care Res. 2011;63(1):94–101.CrossRef
7.
go back to reference Dreyer L, Kendall S, Danneskiold-Samsoe B, Bartels EM, Bliddal H. Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide. Arthritis Rheum. 2010;62(10):3101–8.PubMedCrossRef Dreyer L, Kendall S, Danneskiold-Samsoe B, Bartels EM, Bliddal H. Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide. Arthritis Rheum. 2010;62(10):3101–8.PubMedCrossRef
8.
go back to reference Lewcun B, Kennedy TM, Tress J, Miller KS, Sherker J, Sherry DD. Predicting suicidal ideation in adolescents with chronic amplified pain: the roles of depression and pain duration. Psychol Serv. 2018;15(3):309–15.PubMedCrossRef Lewcun B, Kennedy TM, Tress J, Miller KS, Sherker J, Sherry DD. Predicting suicidal ideation in adolescents with chronic amplified pain: the roles of depression and pain duration. Psychol Serv. 2018;15(3):309–15.PubMedCrossRef
9.
go back to reference Kashikar-Zuck S, Parkins IS, Graham TB, Lynch AM, Passo M, Johnston M, et al. Anxiety, mood, and behavioral disorders among pediatric patients with juvenile fibromyalgia syndrome. Clin J Pain. 2008;24(7):620–6.PubMedPubMedCentralCrossRef Kashikar-Zuck S, Parkins IS, Graham TB, Lynch AM, Passo M, Johnston M, et al. Anxiety, mood, and behavioral disorders among pediatric patients with juvenile fibromyalgia syndrome. Clin J Pain. 2008;24(7):620–6.PubMedPubMedCentralCrossRef
10.
go back to reference Cousins LA, Kalapurakkel S, Cohen LL, Simons LE. Topical review: resilience resources and mechanisms in pediatric chronic pain. J Pediatr Psychol. 2015;40(9):840–5.PubMedPubMedCentralCrossRef Cousins LA, Kalapurakkel S, Cohen LL, Simons LE. Topical review: resilience resources and mechanisms in pediatric chronic pain. J Pediatr Psychol. 2015;40(9):840–5.PubMedPubMedCentralCrossRef
11.
12.
go back to reference Masten AS, Barnes AJ. Resilience in Children: Developmental Perspectives. Children (Basel, Switzerland). 2018;5(7):98. Masten AS, Barnes AJ. Resilience in Children: Developmental Perspectives. Children (Basel, Switzerland). 2018;5(7):98.
13.
14.
go back to reference Torma LM, Houck GM, Wagnild GM, Messecar D, Jones KD. Growing old with fibromyalgia: factors that predict physical function. Nurs Res. 2013;62(1):16–24.PubMedCrossRef Torma LM, Houck GM, Wagnild GM, Messecar D, Jones KD. Growing old with fibromyalgia: factors that predict physical function. Nurs Res. 2013;62(1):16–24.PubMedCrossRef
15.
go back to reference Gmuca S, Xiao R, Urquhart A, Weiss PF, Gillham JE, Ginsburg KR, et al. The Role of Patient and Parental Resilience in Adolescents with Chronic Musculoskeletal Pain. J Pediatr. 2019;210:118–126.e2. Gmuca S, Xiao R, Urquhart A, Weiss PF, Gillham JE, Ginsburg KR, et al. The Role of Patient and Parental Resilience in Adolescents with Chronic Musculoskeletal Pain. J Pediatr. 2019;210:118–126.e2.
16.
go back to reference Rosenberg AR, Yi-Frazier JP, Eaton L, Wharton C, Cochrane K, Pihoker C, et al. Promoting resilience in stress management: a pilot study of a novel resilience-promoting intervention for adolescents and Young adults with serious illness. J Pediatr Psychol 2015;40(9):992–9. Rosenberg AR, Yi-Frazier JP, Eaton L, Wharton C, Cochrane K, Pihoker C, et al. Promoting resilience in stress management: a pilot study of a novel resilience-promoting intervention for adolescents and Young adults with serious illness. J Pediatr Psychol 2015;40(9):992–9.
17.
go back to reference Ginsburg KR, Jablow MM. Building resilience in children and teens. 2nd ed. Itasca: American Academy of Pediatrics; 2005. Ginsburg KR, Jablow MM. Building resilience in children and teens. 2nd ed. Itasca: American Academy of Pediatrics; 2005.
18.
go back to reference Rosenberg AR, Bradford MC, McCauley E, Curtis JR, Wolfe J, Baker KS, et al. Promoting resilience in adolescents and young adults with cancer: results from the PRISM randomized controlled trial. Cancer. 2018;124(19):3909–17.PubMedCrossRef Rosenberg AR, Bradford MC, McCauley E, Curtis JR, Wolfe J, Baker KS, et al. Promoting resilience in adolescents and young adults with cancer: results from the PRISM randomized controlled trial. Cancer. 2018;124(19):3909–17.PubMedCrossRef
19.
go back to reference Winsett RP, Stender SR, Gower G, Burghen GA. Adolescent self-efficacy and resilience in participants attending a diabetes camp. Pediatr Nurs. 2010;36(6):293–6 quiz 7.PubMed Winsett RP, Stender SR, Gower G, Burghen GA. Adolescent self-efficacy and resilience in participants attending a diabetes camp. Pediatr Nurs. 2010;36(6):293–6 quiz 7.PubMed
20.
go back to reference Rosenberg AR, Bradford MC, Barton KS, Etsekson N, McCauley E, Curtis JR, et al. Hope and benefit finding: results from the PRISM randomized controlled trial. Pediatr Blood Cancer. 2019;66(1):e27485.PubMedCrossRef Rosenberg AR, Bradford MC, Barton KS, Etsekson N, McCauley E, Curtis JR, et al. Hope and benefit finding: results from the PRISM randomized controlled trial. Pediatr Blood Cancer. 2019;66(1):e27485.PubMedCrossRef
21.
go back to reference Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62(5):600–10.CrossRef Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62(5):600–10.CrossRef
22.
go back to reference Walker LS, Greene JW. The functional disability inventory: measuring a neglected dimension of child health status. J Pediatr Psychol. 1991;16(1):39–58.PubMedCrossRef Walker LS, Greene JW. The functional disability inventory: measuring a neglected dimension of child health status. J Pediatr Psychol. 1991;16(1):39–58.PubMedCrossRef
23.
go back to reference Kashikar-Zuck S, Flowers SR, Claar RL, Guite JW, Logan DE, Lynch-Jordan AM, et al. Clinical utility and validity of the functional disability inventory (FDI) among a multicenter sample of youth with chronic pain. Pain. 2011;152(7):1600–7.PubMedPubMedCentralCrossRef Kashikar-Zuck S, Flowers SR, Claar RL, Guite JW, Logan DE, Lynch-Jordan AM, et al. Clinical utility and validity of the functional disability inventory (FDI) among a multicenter sample of youth with chronic pain. Pain. 2011;152(7):1600–7.PubMedPubMedCentralCrossRef
24.
go back to reference Claar RL, Walker LS. Functional assessment of pediatric pain patients: psychometric properties of the functional disability inventory. Pain. 2006;121(1–2):77–84.PubMedPubMedCentralCrossRef Claar RL, Walker LS. Functional assessment of pediatric pain patients: psychometric properties of the functional disability inventory. Pain. 2006;121(1–2):77–84.PubMedPubMedCentralCrossRef
25.
go back to reference McGrath PA, Gillespie J. Pain assessment in children and adolescents. In: Turk DC, Melzack R, editors. Handbook of Pain Assessment. New York: The Guildford Press; 2001. p. 97–118. McGrath PA, Gillespie J. Pain assessment in children and adolescents. In: Turk DC, Melzack R, editors. Handbook of Pain Assessment. New York: The Guildford Press; 2001. p. 97–118.
26.
go back to reference Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 1990;33(2):160–72.PubMedCrossRef Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 1990;33(2):160–72.PubMedCrossRef
27.
go back to reference Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RL, et al. 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319–29.PubMedCrossRef Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RL, et al. 2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319–29.PubMedCrossRef
28.
go back to reference Wei C, Hoff A, Villabø MA, Peterman J, Kendall PC, Piacentini J, et al. Assessing anxiety in youth with the multidimensional anxiety scale for children (MASC). J Clin Child Adolesc Psychol. 2014;43(4):566–78.PubMedCrossRef Wei C, Hoff A, Villabø MA, Peterman J, Kendall PC, Piacentini J, et al. Assessing anxiety in youth with the multidimensional anxiety scale for children (MASC). J Clin Child Adolesc Psychol. 2014;43(4):566–78.PubMedCrossRef
29.
go back to reference March JS, Parker JD, Sullivan K, Stallings P, Conners CK. The multidimensional anxiety scale for children (MASC): factor structure, reliability, and validity. J Am Acad Child Psy. 1997;36(4):554–65.CrossRef March JS, Parker JD, Sullivan K, Stallings P, Conners CK. The multidimensional anxiety scale for children (MASC): factor structure, reliability, and validity. J Am Acad Child Psy. 1997;36(4):554–65.CrossRef
30.
go back to reference March JS, Sullivan K. Test-retest reliability of the multidimensional anxiety scale for children. J Anxiety Disord. 1999;13(4):349–58.CrossRefPubMed March JS, Sullivan K. Test-retest reliability of the multidimensional anxiety scale for children. J Anxiety Disord. 1999;13(4):349–58.CrossRefPubMed
31.
go back to reference Limbers C, Young D, Jernigan S, Bryant W, Stephen M. Comparison between objective measures and parental behavioral rating scales of memory and attention in pediatric endocrinology patients. Appl Neuropsychol Child. 2016:1–8. Limbers C, Young D, Jernigan S, Bryant W, Stephen M. Comparison between objective measures and parental behavioral rating scales of memory and attention in pediatric endocrinology patients. Appl Neuropsychol Child. 2016:1–8.
32.
go back to reference Varni JW, Limbers CA, Sorensen LG, Neighbors K, Martz K, Bucuvalas JC, et al. PedsQL™ cognitive functioning scale in pediatric liver transplant recipients: feasibility, Reliability and Validity. Qual Life Res. 2011;20(6):913–21.PubMedCrossRef Varni JW, Limbers CA, Sorensen LG, Neighbors K, Martz K, Bucuvalas JC, et al. PedsQL™ cognitive functioning scale in pediatric liver transplant recipients: feasibility, Reliability and Validity. Qual Life Res. 2011;20(6):913–21.PubMedCrossRef
33.
go back to reference Varni JW, Limbers CA. The PedsQL multidimensional fatigue scale in young adults: feasibility, reliability and validity in a university student population. Qual Life Res. 2008;17(1):105–14.PubMedCrossRef Varni JW, Limbers CA. The PedsQL multidimensional fatigue scale in young adults: feasibility, reliability and validity in a university student population. Qual Life Res. 2008;17(1):105–14.PubMedCrossRef
34.
go back to reference Kovacs M. Children's depression inventory (CDI and CDI 2). The Encyclopedia of Clinical Psychology. Hoboken: Wiley; 2014. Kovacs M. Children's depression inventory (CDI and CDI 2). The Encyclopedia of Clinical Psychology. Hoboken: Wiley; 2014.
35.
go back to reference Gioia GA, Insquith PK, Guy SC, Kenworthy L. Behavior Rating Inventory of Executive Function. 2nd ed. Lutz: Psychological Assessment Resources; 2015. BRIEF2. Gioia GA, Insquith PK, Guy SC, Kenworthy L. Behavior Rating Inventory of Executive Function. 2nd ed. Lutz: Psychological Assessment Resources; 2015. BRIEF2.
36.
go back to reference Forrest CB, Bevans KB, Pratiwadi R, Moon J, Teneralli RE, Minton JM, et al. Development of the PROMIS (R) pediatric global health (PGH-7) measure. Qual Life Res. 2014;23(4):1221–31.PubMedCrossRef Forrest CB, Bevans KB, Pratiwadi R, Moon J, Teneralli RE, Minton JM, et al. Development of the PROMIS (R) pediatric global health (PGH-7) measure. Qual Life Res. 2014;23(4):1221–31.PubMedCrossRef
37.
go back to reference Forrest CB, Tucker CA, Ravens-Sieberer U, Pratiwadi R, Moon J, Teneralli RE, et al. Concurrent validity of the PROMIS(R) pediatric global health measure. Qual Life Res. 2016;25(3):739–51.PubMedCrossRef Forrest CB, Tucker CA, Ravens-Sieberer U, Pratiwadi R, Moon J, Teneralli RE, et al. Concurrent validity of the PROMIS(R) pediatric global health measure. Qual Life Res. 2016;25(3):739–51.PubMedCrossRef
38.
go back to reference Pritzker S, Minter A. Measuring adolescent resilience: an examination of the cross-ethnic validity of the RS-14. Child Youth Serv Res. 2014;44(C):328–33.CrossRef Pritzker S, Minter A. Measuring adolescent resilience: an examination of the cross-ethnic validity of the RS-14. Child Youth Serv Res. 2014;44(C):328–33.CrossRef
39.
go back to reference Wagnild G. The resilience scale User's guide for the US English version of the resilience scale and the 14-item resilience scale (RS-14); 2009. Wagnild G. The resilience scale User's guide for the US English version of the resilience scale and the 14-item resilience scale (RS-14); 2009.
41.
go back to reference Wagnild GM, Young HM. Development and psychometric evaluation of the resilience scale. J Nurs Meas. 1993;1(2):165–78.PubMed Wagnild GM, Young HM. Development and psychometric evaluation of the resilience scale. J Nurs Meas. 1993;1(2):165–78.PubMed
42.
go back to reference Flowers SR, Kashikar-Zuck S. Measures of juvenile fibromyalgia: Functional Disability Inventory (FDI), Modified Fibromyalgia Impact Questionnaire-Child Version (MFIQ-C), and Pediatric Quality of Life Inventory (PedsQL) 3.0 Rheumatology Module Pain and Hurt Scale. Arthritis Care Res. 2011;63(Suppl 11):S431–7.CrossRef Flowers SR, Kashikar-Zuck S. Measures of juvenile fibromyalgia: Functional Disability Inventory (FDI), Modified Fibromyalgia Impact Questionnaire-Child Version (MFIQ-C), and Pediatric Quality of Life Inventory (PedsQL) 3.0 Rheumatology Module Pain and Hurt Scale. Arthritis Care Res. 2011;63(Suppl 11):S431–7.CrossRef
43.
go back to reference Wagnild GM. The resilience scale user's guide: for the US English version of the resilience scale and the 14-item resilience scale (RS-14): resilience center; 2009. Wagnild GM. The resilience scale user's guide: for the US English version of the resilience scale and the 14-item resilience scale (RS-14): resilience center; 2009.
44.
go back to reference Campbell-Sills L, Stein MB. Psychometric analysis and refinement of the Connor-davidson resilience scale (CD-RISC): validation of a 10-item measure of resilience. J Trauma Stress. 2007;20(6):1019–28.PubMedCrossRef Campbell-Sills L, Stein MB. Psychometric analysis and refinement of the Connor-davidson resilience scale (CD-RISC): validation of a 10-item measure of resilience. J Trauma Stress. 2007;20(6):1019–28.PubMedCrossRef
45.
go back to reference Connor KM, Davidson JR. Development of a new resilience scale: the Connor-Davidson resilience scale (CD-RISC). Depress Anxiety. 2003;18(2):76–82.PubMedCrossRef Connor KM, Davidson JR. Development of a new resilience scale: the Connor-Davidson resilience scale (CD-RISC). Depress Anxiety. 2003;18(2):76–82.PubMedCrossRef
46.
go back to reference Helmreich I, Kunzler A, Chmitorz A, König J, Binder H, Wessa M, et al. Psychological interventions for resilience enhancement in adults. Cochrane Database Syst Rev. 2017;2. Helmreich I, Kunzler A, Chmitorz A, König J, Binder H, Wessa M, et al. Psychological interventions for resilience enhancement in adults. Cochrane Database Syst Rev. 2017;2.
47.
go back to reference Gmuca S, Sherry DD. Fibromyalgia: Treating Pain in the Juvenile Patient. Pediatr Drugs. 2017;19(4):325–338.CrossRef Gmuca S, Sherry DD. Fibromyalgia: Treating Pain in the Juvenile Patient. Pediatr Drugs. 2017;19(4):325–338.CrossRef
48.
go back to reference Sherry DD, Brake L, Tress JL, Sherker J, Fash K, Ferry K, et al. The treatment of juvenile fibromyalgia with an intensive physical and psychosocial program. J Pediatr. 2015;167(3):731–7.PubMedCrossRef Sherry DD, Brake L, Tress JL, Sherker J, Fash K, Ferry K, et al. The treatment of juvenile fibromyalgia with an intensive physical and psychosocial program. J Pediatr. 2015;167(3):731–7.PubMedCrossRef
Metadata
Title
Suicidal risk and resilience in juvenile fibromyalgia syndrome: a cross-sectional cohort study
Authors
Sabrina Gmuca
Maitry Sonagra
Rui Xiao
Kimberly S. Miller
Nina H. Thomas
Jami F. Young
Pamela F. Weiss
David D. Sherry
Jeffrey S. Gerber
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue 1/2021
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/s12969-020-00487-w

Other articles of this Issue 1/2021

Pediatric Rheumatology 1/2021 Go to the issue