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Social Psychiatry and Psychiatric Epidemiology

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01-03-2019 | Affective Disorder | Original Paper

Psychotic experiences and mood episodes predict each other bidirectionally: a 6-year follow-up study in a community-based population

Authors: Umut Kırlı, Tolga Binbay, Marjan Drukker, Jim van Os, Köksal Alptekin, Bülent Kayahan, Hayriye Elbi

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 3/2019

Abstract

Background

Psychotic experiences (PEs) are not exclusive to psychotic disorders and highly correlated with mood episodes. In this representative general population-based study, longitudinal bidirectional associations between the extended psychosis phenotype and mood episodes were investigated, accounting for other possible causes.

Methods

Households were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighbourhoods at baseline (n = 4011) and at 6-year follow-up (n = 2185). Participants were interviewed with the relevant sections of the composite international diagnostic interview both at baseline and at follow-up. Sociodemographic, familial and environmental risk factors associated with the extended psychosis phenotype and mood episodes were assessed. Logistic regression and cross-lagged panel correlation models were used for the associations between the extended psychosis phenotype and mood episodes.

Results

PEs were associated with subsequent depressive and manic episodes. There was bidirectionality in that mood episodes were associated with subsequent PEs, and PEs were associated with subsequent mood episodes. The associations occurred in a sub-additive pattern. There were substantial synchronous and cross-lagged correlations between these psychopathology domains, with reciprocally similar cross-lagged correlations. Familial risk and adverse life events were associated with both psychopathology domains, whereas some sociodemographic risk factors and alcohol/cannabis use were associated with only one domain.

Conclusion

The sub-additive bidirectional associations between PEs and mood episodes over time and the similarity of cross-lagged correlations are suggestive of mutually causal connections between affective and psychotic domains of psychopathology.

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Title: Psychotic experiences and mood episodes predict each other bidirectionally: a 6-year follow-up study in a community-based population
Authors: Umut Kırlı
Tolga Binbay
Marjan Drukker
Jim van Os
Köksal Alptekin
Bülent Kayahan
Hayriye Elbi
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Keywords: Affective Disorder
Affective Disorder
Manic Episode
Published in: Social Psychiatry and Psychiatric Epidemiology / Issue 3/2019
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-018-1641-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Psychotic experiences and mood episodes predict each other bidirectionally: a 6-year follow-up study in a community-based population

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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