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Social Psychiatry and Psychiatric Epidemiology
Published in: Social Psychiatry and Psychiatric Epidemiology 3/2019

01-03-2019 | Original Paper

A comparison of neurocognition and functioning in first episode psychosis populations: do research samples reflect the real world?

Authors: Emily Kline, Victoria Hendel, Michelle Friedman-Yakoobian, Raquelle I. Mesholam-Gately, Ann Findeisen, Suzanna Zimmet, Joanne D. Wojcik, Tracey L. Petryshen, Tsung-Ung W. Woo, Jill M. Goldstein, Martha E. Shenton, Matcheri S. Keshavan, Robert W. McCarley, Larry J. Seidman

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 3/2019

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Abstract

Purpose

The current study evaluates the demographic, clinical, and neurocognitive characteristics of a recruited FEP research sample, a research control group, and a FEP clinic sample that were assessed and treated within the same center and time period.

Methods

This study utilized data collected through an observational study and a retrospective chart review. Samples were ascertained in the Longitudinal Assessment and Monitoring of Clinical Status and Brain Function in Adolescents and Adults study and the Prevention and Recovery in Early Psychosis clinic. FEP clinic patients (n = 77), FEP research participants (n = 44), and age-matched controls (n = 38) were assessed using the MATRICS consensus cognitive battery and global functioning social and role scales. Between-group differences were assessed via one-way ANOVA and Chi-square analyses.

Results

No significant differences were observed between groups with regard to age and gender. The FEP research sample had a higher proportion of white participants, better social and role functioning, and better neurocognitive performance when compared with the FEP clinical population. The clinic sample also had more diagnostic variability and higher prevalence of substance use disorders relative to the FEP research sample.

Conclusions

Researchers should be aware of how study design and recruitment practices may impact the representativeness of samples, with particular concern for equal representation of racial minorities and patients with more severe illness. Studies should be designed to minimize burden to promote a wider range of participation.
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Metadata
Title
A comparison of neurocognition and functioning in first episode psychosis populations: do research samples reflect the real world?
Authors
Emily Kline
Victoria Hendel
Michelle Friedman-Yakoobian
Raquelle I. Mesholam-Gately
Ann Findeisen
Suzanna Zimmet
Joanne D. Wojcik
Tracey L. Petryshen
Tsung-Ung W. Woo
Jill M. Goldstein
Martha E. Shenton
Matcheri S. Keshavan
Robert W. McCarley
Larry J. Seidman
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
Social Psychiatry and Psychiatric Epidemiology / Issue 3/2019
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI
https://doi.org/10.1007/s00127-018-1631-x

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