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International Journal of Colorectal Disease

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Open Access 01-12-2024 | Mood Disorders | REVIEW

Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data

Authors: Shijun Xia, Yuwen Zhu, Lidan Luo, Wenjiang Wu, Lijuan Ma, Linchong Yu, Yue Li

Published in: International Journal of Colorectal Disease | Issue 1/2024

Abstract

Background

Depression and anxiety are common mental disorders in patients with colorectal cancer (CRC); however, it remains unclear whether they are related to cancer mortality.

Method

Based on a systematic literature search, 12 eligible studies involving 26,907 patients with CRC were included in this study.

Results

Univariate analysis revealed that anxiety was associated with an all-cause mortality rate of 1.42 (1.02, 1.96), whereas multivariate analysis revealed that anxiety was not associated with an all-cause mortality rate of 0.73 (0.39, 1.36). In univariate and multivariate analyses, depression was associated with all-cause mortality rates of 1.89 (1.68, 2.13) and 1.62 (1.27, 2.06), respectively, but not with the cancer-associated mortality rate of 1.16 (0.91, 1.48) in multivariate analyses. Multivariate subgroup analysis of depression and all-cause mortality showed that younger age (≤65 years), being diagnosed with depression/anxiety after a confirmed cancer diagnosis, and shorter follow-up time (<5 years) were associated with poor prognosis.

Conclusions

Our study emphasizes the key roles of depression and anxiety as independent factors for predicting the survival of patients with CRC. However, owing to the significant heterogeneity among the included studies, the results should be interpreted with caution. Early detection and effective treatment of depression and anxiety in patients with CRC have public health and clinical significance.

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Title: Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data
Authors: Shijun Xia
Yuwen Zhu
Lidan Luo
Wenjiang Wu
Lijuan Ma
Linchong Yu
Yue Li
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Mood Disorders
Affective Disorder
Colorectal Cancer
Colorectal Cancer
Anxiety
Published in: International Journal of Colorectal Disease / Issue 1/2024
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-024-04619-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data

Abstract

Background

Method

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusions

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