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International Journal of Colorectal Disease

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Open Access 01-12-2024 | Rectal Cancer | RESEARCH

Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries

Authors: John Andersson, Eva Angenete, Martin Gellerstedt, Eva Haglind

Published in: International Journal of Colorectal Disease | Issue 1/2024

Abstract

Purpose

Rectal cancer and its treatment have a negative impact on health-related quality of life (HRQoL). If risk factors for sustained low HRQoL could be identified early, ideally before the start of treatment, individualised interventions could be identified and implemented to maintain or improve HRQoL. The study aimed to develop a multivariable prediction model for global HRQoL 12 months after rectal cancer treatment.

Methods

Within COLOR II, a randomised, multicentre, international trial of laparoscopic and open surgery for rectal cancer, a sub-study on HRQoL included 385 patients in 12 hospitals and five countries. The HRQoL study was optional for hospitals in the COLOR II trial. EORTC QLQ-C30 and EORTC QLQ-CR38 were analysed preoperatively and at 1 and 12 months postoperatively. In exploratory analyses, correlations between age, sex, fatigue, pain, ASA classification, complications, and symptoms after surgery to HRQoL were studied. Bivariate initial analyses were followed by multivariate regression models.

Results

Patient characteristics and clinical factors explained 4–10% of the variation in global HRQoL. The patient-reported outcomes from EORTC QLQ-C30 explained 55–65% of the variation in global HRQoL. The predominant predictors were fatigue and pain, which significantly impacted global HRQoL at all time points measured.

Conclusion

We found that fatigue and pain were two significant factors associated with posttreatment global HRQoL in patients treated for rectal cancer T1-T3 Nx. Interventions to reduce fatigue and pain could enhance global HRQoL after rectal cancer treatment.

Trial registration

This trial is registered with ClinicalTrials.gov No. NCT00297791

Available only for authorised users

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Title: Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries
Authors: John Andersson
Eva Angenete
Martin Gellerstedt
Eva Haglind
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Keywords: Rectal Cancer
Rectal Cancer
Fatigue
Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 1/2024
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-024-04605-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries

Abstract

Purpose

Methods

Results

Conclusion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Trial registration

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