Skip to main content
Top
Published in: Current Diabetes Reports 5/2020

01-05-2020 | Mood Disorders | Psychosocial Aspects (SS Jaser, Section Editor)

Novel Challenges in Aging with Type 1 Diabetes

Authors: Jeoffrey A. Bispham, Allyson S. Hughes, Kimberly A. Driscoll, Alicia H. McAuliffe-Fogarty

Published in: Current Diabetes Reports | Issue 5/2020

Login to get access

Abstract

Purpose of Review

Due to treatment advancements, individuals with type 1 diabetes (T1D) are living longer, presenting a unique understudied population with advanced complex needs. This article is a review of the aging literature in T1D and identifies existing gaps while serving as a call to the research community.

Recent Findings

Recent studies have identified an association between cognitive impairment and glycemic variability, as well as increased risk and frequency of hypoglycemia in older adults with T1D. However, limited research exists about additional physical and mental health conditions and barrier to successful treatment in this population.

Summary

Older adults may experience both age- and diabetes-related barriers to diabetes management. Due to the scarcity of aging T1D research, current treatment guidelines for this age group are based on type 2 diabetes research. There is a critical need to further investigate the physical and mental effects of T1D and aging as well as public health policy; insurance challenges; and needs for support and interventions for older adults with T1D.
Literature
25.
go back to reference •• Gilsanz P, Schnaider Beeri M, Karter AJ, Quesenberry CP, Adams AS, Whitmer RA. Depression in type 1 diabetes and risk of dementia. Aging Ment Health. 2019;23(7):880–6. https://doi.org/10.1080/13607863.2018.1455167This study provides evidence that risk of dementia is significantly increased with the occurrence of depression in adults with type 1 diabetes aged ≥ 50. CrossRefPubMed •• Gilsanz P, Schnaider Beeri M, Karter AJ, Quesenberry CP, Adams AS, Whitmer RA. Depression in type 1 diabetes and risk of dementia. Aging Ment Health. 2019;23(7):880–6. https://​doi.​org/​10.​1080/​13607863.​2018.​1455167This study provides evidence that risk of dementia is significantly increased with the occurrence of depression in adults with type 1 diabetes aged ≥ 50. CrossRefPubMed
39.
go back to reference Bauer S, Nauck MA. Polypharmacy in people with type 1 and type 2 diabetes is justified by current guidelines-a comprehensive assessment of drug prescriptions in patients needing inpatient treatment for diabetes-associated problems. Diabet Med. 2014;31(9):1078–85. https://doi.org/10.1111/dme.12497.CrossRefPubMed Bauer S, Nauck MA. Polypharmacy in people with type 1 and type 2 diabetes is justified by current guidelines-a comprehensive assessment of drug prescriptions in patients needing inpatient treatment for diabetes-associated problems. Diabet Med. 2014;31(9):1078–85. https://​doi.​org/​10.​1111/​dme.​12497.CrossRefPubMed
42.
go back to reference Roussel R, Moutairou A, Riveline J-P, Gautier J-F, Potier L. 1091-P: association between mild and severe hypoglycemia in people with T1 and T2 diabetes enrolled in randomized controlled trials for assessing insulin therapy. Diabetes. 2019;68(Suppl. 1):1091. https://doi.org/10.2337/db19-1091-P.CrossRef Roussel R, Moutairou A, Riveline J-P, Gautier J-F, Potier L. 1091-P: association between mild and severe hypoglycemia in people with T1 and T2 diabetes enrolled in randomized controlled trials for assessing insulin therapy. Diabetes. 2019;68(Suppl. 1):1091. https://​doi.​org/​10.​2337/​db19-1091-P.CrossRef
48.
go back to reference •• Chaytor NS, Barbosa-Leiker C, Ryan CM, Germine LT, Hirsch IB, Weinstock RS. Clinically significant cognitive impairment in older adults with type 1 diabetes. J Diabetes Complicat. 2019;33(1):91–7. https://doi.org/10.1016/j.jdiacomp.2018.04.003This study identified the prevalence of clinically significant cognitive impairment in older adults with type 1 diabetes and diabetes-related factors correlated with impairment. CrossRefPubMed •• Chaytor NS, Barbosa-Leiker C, Ryan CM, Germine LT, Hirsch IB, Weinstock RS. Clinically significant cognitive impairment in older adults with type 1 diabetes. J Diabetes Complicat. 2019;33(1):91–7. https://​doi.​org/​10.​1016/​j.​jdiacomp.​2018.​04.​003This study identified the prevalence of clinically significant cognitive impairment in older adults with type 1 diabetes and diabetes-related factors correlated with impairment. CrossRefPubMed
49.
go back to reference Mattishent K, Richardson K, Dhatariya K, Savva GM, Fox C, Loke YK. The effects of hypoglycaemia and dementia on cardiovascular events, falls and fractures and all-cause mortality in older individuals: a retrospective cohort study. Diabetes Obes Metab. 2019:1–10. https://doi.org/10.1111/dom.13769. Mattishent K, Richardson K, Dhatariya K, Savva GM, Fox C, Loke YK. The effects of hypoglycaemia and dementia on cardiovascular events, falls and fractures and all-cause mortality in older individuals: a retrospective cohort study. Diabetes Obes Metab. 2019:1–10. https://​doi.​org/​10.​1111/​dom.​13769.
52.
go back to reference Administration SA and MHS. Key substance use and mental health indicators in the United States: results from the 2017 National Survey on Drug Use and Health. Rockville, MD; 2018. https://www.samhsa.gov/data/. Accessed 10 Feb 2020. Administration SA and MHS. Key substance use and mental health indicators in the United States: results from the 2017 National Survey on Drug Use and Health. Rockville, MD; 2018. https://​www.​samhsa.​gov/​data/​. Accessed 10 Feb 2020.
Metadata
Title
Novel Challenges in Aging with Type 1 Diabetes
Authors
Jeoffrey A. Bispham
Allyson S. Hughes
Kimberly A. Driscoll
Alicia H. McAuliffe-Fogarty
Publication date
01-05-2020
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 5/2020
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-020-01298-9
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine