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Published in: Heart and Vessels 2/2023

28-07-2022 | Affective Disorder | Original Article

Comparison of the incidence of depression before and after endovascular treatment in patients with lower limb peripheral artery disease

Authors: Yasushi Komatsu, Michiaki Higashitani, Daisuke Ueshima, Atsushi Mizuno, Tetsuo Yamaguchi, Takahide Kodama, Tomofumi Tanaka, Kentaro Jujo, Naotaka Murata, Satoko Ookoshi, Tetsuya Ochiai, Yuji Taya, Yoshiko Nemoto, Norihiro Abe, Hitoshi Anzai, Taishiro Chikamori

Published in: Heart and Vessels | Issue 2/2023

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Abstract

Depression is a chronic illness that affects mood, physical health, and overall vitality and quality of life. Depression has been associated with an increased risk of all-cause and cardiovascular mortality among patients with peripheral arterial disease (PAD). Therefore, this study aimed to compare the incidence of depression before and after endovascular treatment in patients with lower limb PAD. This is an important clinical issue considering the worldwide increase in PAD with the aging population and the known negative impact of depression on recovery. This was a retrospective sub-analysis of data from the Tokyo Peripheral Vascular Intervention Study using the TOMA-CODE registry. The presence and extent of depressive symptoms were evaluated using the patient health questionnaire (PHQ-9), with a depressive tendency score of ≥ 5. The PHQ-9 score was evaluated before endovascular treatment (EVT) and at 4 (± 1) weeks after EVT. The study population consisted of 87 patients who completed the PHQ-9 before EVT, with 76 completing the post-EVT PHQ-9. Of these 76, 19 had a pre-EVT score ≥ 5. Overall, there was no difference in the pre- and post-EVT scores (P = 0.091). There was no significant change in the 19 patients with a pre-EVT score ≥ 5 (mean 9.2 ± 4.4); however, there was a tendency to improve in the pre- to post-EVT score (mean, 6.9 ± 5.2; P = 0.059). Diabetes was a significant negative factor for pre- to post-EVT score improvement (P = 0.023). Overall, symptoms of depression showed the tendency to improve at 30 days post-EVT. However, diabetes was associated with lower improvement in symptoms.
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Metadata
Title
Comparison of the incidence of depression before and after endovascular treatment in patients with lower limb peripheral artery disease
Authors
Yasushi Komatsu
Michiaki Higashitani
Daisuke Ueshima
Atsushi Mizuno
Tetsuo Yamaguchi
Takahide Kodama
Tomofumi Tanaka
Kentaro Jujo
Naotaka Murata
Satoko Ookoshi
Tetsuya Ochiai
Yuji Taya
Yoshiko Nemoto
Norihiro Abe
Hitoshi Anzai
Taishiro Chikamori
Publication date
28-07-2022
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 2/2023
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-022-02149-1

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