Skip to main content
Top
Published in: BMC Gastroenterology 1/2023

Open Access 01-12-2023 | Mood Disorders | Research article

Behaviour regulation and the role of mental health in non-alcoholic fatty liver disease

Authors: E. Asquith, K. Bould, J. C. Catling, E. J. Day, A. Holt

Published in: BMC Gastroenterology | Issue 1/2023

Login to get access

Abstract

Background and aims

Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in wealthy societies, and is responsible for a significant rise in liver morbidity and mortality. Current treatments prioritise lifestyle interventions, predominantly diet and exercise management, but patients frequently fail to make the necessary behavioural adjustments. The current study seeks to identify those factors which influence patients’ behaviour with respect to adherence to treatment regimes.

Methods

Novel areas of interest were investigated; locus of control, behavioural regulation and a range of mental health measures, due to their links to either poor lifestyle choices or abnormal eating as identified in previous literature. Data was gathered using self-report questionnaires, from 96 participants, who were split into three groups, NAFLD patients, non-NAFLD liver disease patients and healthy controls

Results

Data was analysed using a MANOVA, and followed up with a Tukey post-hoc test. Three factors were found to be significant by group; cognitive restraint, uncontrolled eating and SAPAS score (a measure of personality disorders). An association between personality disorders and NAFLD was identified.

Conclusion

It is suggested that NAFLD patients are screened for personality disorders and, if identified, treated prior to the commencement of diet and exercise management.
Literature
1.
go back to reference Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA. 2015;313(22):2263–73.PubMed Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA. 2015;313(22):2263–73.PubMed
2.
go back to reference Younossi ZM, Marchesini G, Pinto-Cortez H, Petta S. Epidemiology of non alcoholic fatty liver disease and non alcoholic steatohepatitis: implications for liver transplantation. Transplantation. 2019;103(1):22–7.PubMed Younossi ZM, Marchesini G, Pinto-Cortez H, Petta S. Epidemiology of non alcoholic fatty liver disease and non alcoholic steatohepatitis: implications for liver transplantation. Transplantation. 2019;103(1):22–7.PubMed
3.
go back to reference Tuyama AC, Chang CY. Non-alcoholic fatty liver disease. J Diabetes. 2012;4(3):266–80.PubMed Tuyama AC, Chang CY. Non-alcoholic fatty liver disease. J Diabetes. 2012;4(3):266–80.PubMed
4.
go back to reference Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005–23.PubMed Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M, Sanyal AJ. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005–23.PubMed
5.
go back to reference Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol. 2013;10(11):686–90.PubMed Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol. 2013;10(11):686–90.PubMed
7.
go back to reference Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, Romero-Gomez M. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015;149(2):367–78.PubMed Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, Romero-Gomez M. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015;149(2):367–78.PubMed
8.
go back to reference Noto H, Tokushige K, Hashimoto E, Taniai M, Shiratori K. Questionnaire survey on lifestyle of patients with nonalcoholic steatohepatitis. J Clin Biochem Nutr. 2014;55(3):191–5.PubMedPubMedCentral Noto H, Tokushige K, Hashimoto E, Taniai M, Shiratori K. Questionnaire survey on lifestyle of patients with nonalcoholic steatohepatitis. J Clin Biochem Nutr. 2014;55(3):191–5.PubMedPubMedCentral
9.
go back to reference Moore MP, Cunningham RP, Dashek RJ, Mucinski JM, Rector RS. A fad too far? Dietary strategies for the prevention and treatment of NAFLD. Obesity. 2020;28(10):1843–52.PubMed Moore MP, Cunningham RP, Dashek RJ, Mucinski JM, Rector RS. A fad too far? Dietary strategies for the prevention and treatment of NAFLD. Obesity. 2020;28(10):1843–52.PubMed
10.
go back to reference Dureja P, Mellinger J, Agni R, Chang F, Avey G, Lucey M, Said A. NAFLD recurrence in liver transplant recipients. Transplantation. 2011;91(6):684–9.PubMed Dureja P, Mellinger J, Agni R, Chang F, Avey G, Lucey M, Said A. NAFLD recurrence in liver transplant recipients. Transplantation. 2011;91(6):684–9.PubMed
11.
go back to reference Elfhag K, Rössner S. Who succeeds in maintaining weight loss? a conceptual review of factors associated with weight loss maintenance and weight regain. Obes Rev. 2005;6(1):67–85.PubMed Elfhag K, Rössner S. Who succeeds in maintaining weight loss? a conceptual review of factors associated with weight loss maintenance and weight regain. Obes Rev. 2005;6(1):67–85.PubMed
12.
go back to reference Nir Z, Neumann L. Relationship among self-esteem, internal-external locus of control, and weight change after participation in a weight reduction program. J Clin Psychol. 1995;51(4):482–90.PubMed Nir Z, Neumann L. Relationship among self-esteem, internal-external locus of control, and weight change after participation in a weight reduction program. J Clin Psychol. 1995;51(4):482–90.PubMed
13.
go back to reference Swann AC, Lijffijt M, Lane SD, Steinberg JL, Moeller FG. Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness. Acta Psychiatr Scand. 2010;121(6):453–61.PubMedPubMedCentral Swann AC, Lijffijt M, Lane SD, Steinberg JL, Moeller FG. Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness. Acta Psychiatr Scand. 2010;121(6):453–61.PubMedPubMedCentral
14.
go back to reference Tyrer P, Reed GM, Crawford MJ. Classification, assessment, prevalence, and effect of personality disorder. The Lancet. 2015;385(9969):717–26. Tyrer P, Reed GM, Crawford MJ. Classification, assessment, prevalence, and effect of personality disorder. The Lancet. 2015;385(9969):717–26.
15.
go back to reference Gerlach G, Loeber S, Herpertz S. Personality disorders and obesity: a systematic review. Obes Rev. 2016;17(8):691–723.PubMed Gerlach G, Loeber S, Herpertz S. Personality disorders and obesity: a systematic review. Obes Rev. 2016;17(8):691–723.PubMed
16.
go back to reference Wilson ST, Stanley B, Oquendo MA, Goldberg P, Zalsman G, Mann JJ. Comparing impulsiveness, hostility, and depression in borderline personality disorder and bipolar II disorder. J Clin Psychiatry. 2007;68(10):0. Wilson ST, Stanley B, Oquendo MA, Goldberg P, Zalsman G, Mann JJ. Comparing impulsiveness, hostility, and depression in borderline personality disorder and bipolar II disorder. J Clin Psychiatry. 2007;68(10):0.
17.
go back to reference Guerrieri R, Nederkoorn C, Schrooten M, Martijn C, Jansen A. Inducing impulsivity leads high and low restrained eaters into overeating, whereas current dieters stick to their diet. Appetite. 2009;53(1):93–100.PubMed Guerrieri R, Nederkoorn C, Schrooten M, Martijn C, Jansen A. Inducing impulsivity leads high and low restrained eaters into overeating, whereas current dieters stick to their diet. Appetite. 2009;53(1):93–100.PubMed
18.
go back to reference Yeomans MR, Leitch M, Mobini S. Impulsivity is associated with the disinhibition but not restraint factor from the three factor eating questionnaire. Appetite. 2008;50(2–3):469–76.PubMed Yeomans MR, Leitch M, Mobini S. Impulsivity is associated with the disinhibition but not restraint factor from the three factor eating questionnaire. Appetite. 2008;50(2–3):469–76.PubMed
19.
go back to reference Goossens L, Braet C, Van Vlierberghe L, Mels S. Loss of control over eating in overweight youngsters: the role of anxiety, depression and emotional eating. Eur Eat Disord Rev. 2009;17(1):68–78.PubMed Goossens L, Braet C, Van Vlierberghe L, Mels S. Loss of control over eating in overweight youngsters: the role of anxiety, depression and emotional eating. Eur Eat Disord Rev. 2009;17(1):68–78.PubMed
20.
go back to reference Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220–9.PubMed Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220–9.PubMed
21.
go back to reference Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.PubMed Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.PubMed
22.
go back to reference Karlsson J, Persson LO, Sjöström L, Sullivan M. Psychometric properties and factor structure of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women. results from the Swedish Obese Subjects (SOS) study. Int J Obes. 2000;24(12):1715–25. Karlsson J, Persson LO, Sjöström L, Sullivan M. Psychometric properties and factor structure of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women. results from the Swedish Obese Subjects (SOS) study. Int J Obes. 2000;24(12):1715–25.
23.
go back to reference Markland D, Tobin V. A modification to the behavioural regulation in exercise questionnaire to include an assessment of amotivation. J Sport Exerc Psychol. 2004;26(2):191–6. Markland D, Tobin V. A modification to the behavioural regulation in exercise questionnaire to include an assessment of amotivation. J Sport Exerc Psychol. 2004;26(2):191–6.
24.
go back to reference Rotter JB. Generalized expectancies for internal versus external control of reinforcement. Psychol Monogr Gen Appl. 1966;80(1):1. Rotter JB. Generalized expectancies for internal versus external control of reinforcement. Psychol Monogr Gen Appl. 1966;80(1):1.
25.
go back to reference Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.PubMed Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.PubMed
26.
go back to reference Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the hospital anxiety and depression scale: an updated literature review. J Psychosom Res. 2002;52(2):69–77.PubMed Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the hospital anxiety and depression scale: an updated literature review. J Psychosom Res. 2002;52(2):69–77.PubMed
27.
go back to reference Moran P, Leese M, Lee T, Walters P, Thornicroft G, Mann A. Standardised Assessment of Personality-Abbreviated Scale (SAPAS): preliminary validation of a brief screen for personality disorder. Br J Psychiatry. 2003;183(3):228–32.PubMed Moran P, Leese M, Lee T, Walters P, Thornicroft G, Mann A. Standardised Assessment of Personality-Abbreviated Scale (SAPAS): preliminary validation of a brief screen for personality disorder. Br J Psychiatry. 2003;183(3):228–32.PubMed
28.
go back to reference Oltmanns TF, Rodrigues MM, Weinstein Y, Gleason ME. Prevalence of personality disorders at midlife in a community sample: Disorders and symptoms reflected in interview, self, and informant reports. J Psychopathol Behav Assess. 2014;36(2):177–88.PubMed Oltmanns TF, Rodrigues MM, Weinstein Y, Gleason ME. Prevalence of personality disorders at midlife in a community sample: Disorders and symptoms reflected in interview, self, and informant reports. J Psychopathol Behav Assess. 2014;36(2):177–88.PubMed
29.
go back to reference Mago R, Gomez JP, Gupta N, Kunkel EJ. Anxiety in medically III patients. Curr Psychiatry Rep. 2006;8(3):228–33.PubMed Mago R, Gomez JP, Gupta N, Kunkel EJ. Anxiety in medically III patients. Curr Psychiatry Rep. 2006;8(3):228–33.PubMed
30.
go back to reference Wilhelm K, Mitchell P, Slade T, Brownhill S, Andrews G. Prevalence and correlates of DSM-IV major depression in an Australian national survey. J Affect Disord. 2003;75(2):155–62.PubMed Wilhelm K, Mitchell P, Slade T, Brownhill S, Andrews G. Prevalence and correlates of DSM-IV major depression in an Australian national survey. J Affect Disord. 2003;75(2):155–62.PubMed
31.
go back to reference Skodol AE, Gunderson JG, Pfohl B, Widiger TA, Livesley WJ, Siever LJ. The borderline diagnosis I: psychopathology, comorbidity, and personaltity structure. Biol Psychiat. 2002;51(12):936–50.PubMed Skodol AE, Gunderson JG, Pfohl B, Widiger TA, Livesley WJ, Siever LJ. The borderline diagnosis I: psychopathology, comorbidity, and personaltity structure. Biol Psychiat. 2002;51(12):936–50.PubMed
32.
go back to reference Svaldi J, Philipsen A, Matthies S. Risky decision-making in borderline personality disorder. Psychiatry Res. 2012;197(1–2):112–8.PubMed Svaldi J, Philipsen A, Matthies S. Risky decision-making in borderline personality disorder. Psychiatry Res. 2012;197(1–2):112–8.PubMed
33.
go back to reference Schuermann B, Kathmann N, Stiglmayr C, Renneberg B, Endrass T. Impaired decision making and feedback evaluation in borderline personality disorder. Psychol Med. 2011;41(9):1917–27.PubMed Schuermann B, Kathmann N, Stiglmayr C, Renneberg B, Endrass T. Impaired decision making and feedback evaluation in borderline personality disorder. Psychol Med. 2011;41(9):1917–27.PubMed
34.
go back to reference Sevastianova K, Santos A, Kotronen A, Hakkarainen A, Makkonen J, Silander K, Peltonen M, Romeo S, Lundbom J, Lundbom N, Olkkonen VM. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr. 2012;96(4):727–34.PubMed Sevastianova K, Santos A, Kotronen A, Hakkarainen A, Makkonen J, Silander K, Peltonen M, Romeo S, Lundbom J, Lundbom N, Olkkonen VM. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr. 2012;96(4):727–34.PubMed
35.
go back to reference Holmer M, Lindqvist C, Petersson S, Moshtaghi-Svensson J, Tillander V, Brismar TB, Stål P. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet–a randomised controlled trial. JHEP Rep. 2021;3(3):100256.PubMedPubMedCentral Holmer M, Lindqvist C, Petersson S, Moshtaghi-Svensson J, Tillander V, Brismar TB, Stål P. Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet–a randomised controlled trial. JHEP Rep. 2021;3(3):100256.PubMedPubMedCentral
36.
go back to reference Rashid M, Roberts EA. Non-alcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2000;30(1):48–53.PubMed Rashid M, Roberts EA. Non-alcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 2000;30(1):48–53.PubMed
37.
go back to reference Rohrer JE, Vickers-Douglas KS, Stroebel RJ. Uncontrolled eating and obesity in adult primary care patients. Obes Res Clin Pract. 2009;3(2):115–21. Rohrer JE, Vickers-Douglas KS, Stroebel RJ. Uncontrolled eating and obesity in adult primary care patients. Obes Res Clin Pract. 2009;3(2):115–21.
38.
go back to reference Banerji O, Hepatitis B. InnovAiT. 2013;6(12):790–800. Banerji O, Hepatitis B. InnovAiT. 2013;6(12):790–800.
39.
go back to reference Davidson K, Norrie J, Tyrer P, Gumley A, Tata P, Murray H, Palmer S. The effectiveness of cognitive behavior therapy for borderline personality disorder: results from the borderline personality disorder study of cognitive therapy (BOSCOT) trial. J Pers Disord. 2006;20(5):450–65.PubMedPubMedCentral Davidson K, Norrie J, Tyrer P, Gumley A, Tata P, Murray H, Palmer S. The effectiveness of cognitive behavior therapy for borderline personality disorder: results from the borderline personality disorder study of cognitive therapy (BOSCOT) trial. J Pers Disord. 2006;20(5):450–65.PubMedPubMedCentral
40.
go back to reference Bateman AW, Gunderson J, Mulder R. Treatment of personality disorder. The Lancet. 2015;385(9969):735–43. Bateman AW, Gunderson J, Mulder R. Treatment of personality disorder. The Lancet. 2015;385(9969):735–43.
41.
go back to reference Huang CY, Liao HY, Chang SH. Social desirability and the clinical self-report inventory: methodological reconsideration. j clin psychol. 1998;54(4):517–28.PubMed Huang CY, Liao HY, Chang SH. Social desirability and the clinical self-report inventory: methodological reconsideration. j clin psychol. 1998;54(4):517–28.PubMed
Metadata
Title
Behaviour regulation and the role of mental health in non-alcoholic fatty liver disease
Authors
E. Asquith
K. Bould
J. C. Catling
E. J. Day
A. Holt
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2023
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-023-02941-x

Other articles of this Issue 1/2023

BMC Gastroenterology 1/2023 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.