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09-04-2024 | Affective Disorder | Original Article

“Association between perinatal mood disorders of parents and child health outcomes”

Authors: Erika Obikane, Hayato Yamana, Sachiko Ono, Hideo Yasunaga, Norito Kawakami

Published in: Archives of Women's Mental Health

Abstract

Purpose

Perinatal mood disorders affect both parents, impacting their children negatively. Little is known on the association between parental perinatal mood disorders and pediatric outcomes in Japan considering relevant covariates. Our objective was to investigate the association between paternal and maternal perinatal mood disorders and adverse physical and psychological child outcomes by the age of 36 months, adjusting for covariates such as the child’s sex, age of parent at child’s birth, perinatal mood disorders of the other parent, and perinatal antidepressant use.

Methods

We identified parents in the JMDC Claims Database in Japan from 2012 to 2020. Perinatal mood disorders were defined using International Classification of Diseases, 10th codes for mood disorders during the perinatal period combined with psychiatric treatment codes. We evaluated the association between parental perinatal mood disorders and pediatric adverse outcomes by the age of 36 months using Cox proportional hazard models adjusted for the covariates.

Results

Of the 116,423 father-mother-child triads, 2.8% of fathers and 2.3% of mothers had perinatal mood disorders. Paternal perinatal mood disorders were not significantly associated with adverse child outcomes. After adjusting for paternal perinatal mood disorders and antidepressant use, maternal perinatal mood disorders were associated with delayed motor development, language development disorders, autism spectrum disorders, and behavioral and emotional disorders (adjusted hazard ratio [95% confidence interval]: 1.65 [1.01–2.69], 2.26 [1.36–3.75], 4.16 [2.64–6.55], and 6.12 [1.35–27.81], respectively).

Conclusions

Paternal perinatal mood disorders were not associated with adverse child outcomes in this population. Maternal perinatal mood disorders were associated with multiple child outcomes.

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Title: “Association between perinatal mood disorders of parents and child health outcomes”
Authors: Erika Obikane
Hayato Yamana
Sachiko Ono
Hideo Yasunaga
Norito Kawakami
Publication date: 09-04-2024
Publisher: Springer Vienna
Keywords: Affective Disorder
Affective Disorder
Autism Spectrum Disorder
Language Development
Antidepressant Drugs
Antidepressant Drugs
Published in: Archives of Women's Mental Health
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-024-01463-z

At a glance: The STEP trials

Springer Medicine

“Association between perinatal mood disorders of parents and child health outcomes”

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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