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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 5/2019

01-05-2019 | Affective Disorder | Original Article

Assessment of Quality of Life, Anxiety and Depressive Symptoms in Serbian Children with Celiac Disease and their Parents

Authors: Biljana Stojanović, Aleksandar Kočović, Nedeljko Radlović, Zoran Leković, Dragan Prokić, Nela Đonović, Stevan Jovanović, Biljana Vuletić

Published in: Indian Journal of Pediatrics | Issue 5/2019

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Abstract

Objectives

To evaluate the level of health-related quality of life (QoL) and presence of anxiety and depressive symptoms in Serbian children with celiac disease from the perspective of patients and their parents.

Methods

This cross-sectional study investigated the group of children and adolescents with celiac disease aged 5–18 y, and at least one parent of each patient with celiac disease. The patients and their parents were recruited at the Institute of Mother and Child Health of Serbia and the University Children’s Hospital in Belgrade. The instruments used in this study were child-self and parent-proxy versions of the Pediatric Quality of Life Inventory (PedsQL), Screen for Child Anxiety Related Emotional Disorder (SCARED) and Short Mood and Feelings Questionnaire (MFQ). Additional information was collected from the medical records of each patient.

Results

According to the PedsQL questionnaire, the quality of life was similarly assessed by both parents and their children (p > 0.05), as well as the presence of depressive symptoms according to MFQ questionnaire. However, a statistically significant difference was observed in the total score of the SCARED questionnaire for children and parents [total score (p < 0.05), panic-somatic disturbance (p < 0.01) and social anxiety (p < 0.01)].

Conclusions

The patients and their parents in Serbia have similarly assessed the quality of life of children with celiac disease, but the differences in the scores of SCARED questionnaire indicate that it is necessary to include both children and parents in the assessment of QOL.
Literature
1.
Schaart MW, Mearin ML. Early nutrition: prevention of celiac disease? J Pediatr Gastroenterol Nutr. 2014;59:S18–20.CrossRefPubMed
2.
Husby S, Koletzko S, Korponay-Szabó IR, et al; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54:136–60.
3.
4.
5.
Epstein I, Stinson J, Stevens B. The effects of camp on health-related quality of life in children with chronic illnesses: a review of the literature. J Pediatr Oncol Nurs. 2005;22:89–103.
6.
7.
Häuser W, Gold J, Stallmach A, Caspary WF, Stein J. Development and validation of the celiac disease questionnaire (CDQ), a disease-specific health-related quality of life measure for adult patients with celiac disease. J Clin Gastroenterol. 2007;41:157–66.CrossRefPubMed
8.
Van Doorn RK, Winkler LM, Zwinderman KH, Mearin ML, Koopman HM. CDDUX: a disease-specific health-related quality-of-life questionnaire for children with celiac disease. J Pediatr Gastroenterol Nutr. 2008;47:147–52.CrossRefPubMed
9.
Aksan A, Mercanlıgil SM, Häuser W, Karaismailoğlu E. Validation of the Turkish version of the celiac disease questionnaire (CDQ). Health Qual Life Outcomes. 2015;13:82.CrossRefPubMedPubMedCentral
10.
Marchese A, Klersy C, Biagi F, et al. Quality of life in coeliac patients: Italian validation of a coeliac questionnaire. Eur J Intern Med. 2013;24:87–91.
11.
Pouchot J, Despujol C, Malamut G, Ecosse E, Coste J, Cellier C. Validation of a French version of the quality of life "celiac disease questionnaire". PLoS One. 2014;9:e96346.
12.
Lins MT, Tassitano RM, Brandt KG, Antunes MM, Silva GA. Translation, cultural adaptation, and validation of the celiac disease DUX (CDDUX). J Pediatr. 2015;91:448–54.CrossRef
13.
Biagetti C, Gesuita R, Gatti S, Catassi C. Quality of life in children with celiac disease: a paediatric cross-sectional study. Dig Liver Dis. 2015;47:927–32.CrossRefPubMed
14.
Smith DF, Gerdes LU. Meta-analysis on anxiety and depression in adult celiac disease. Acta Psychiatr Scand. 2012;125:189–9.
15.
Esenyel S, Unal F, Vural P. Depression and anxiety in child and adolescents with follow-up celiac disease and in their families. Turk J Gastroenterol. 2014;25:381–5.CrossRefPubMed
16.
Stevanović D, Lakić A, Damnjanović M. Some psychometric properties of the pediatric quality of life inventory™ version 4.0 generic Core scales (PedsQL™) in the general Serbian population. Qual Life Res. 2011;20:945–9.CrossRefPubMed
17.
Stevanović D. Childhood depression and anxiety disorders in Serbia: a psychometric study of four screening questionnaires. Epidemiol Psychiatr Sci. 2012;21:111–6.CrossRefPubMed
18.
Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Erlbaum Associates; 1988.
19.
Kuburovic NB, Pasic S, Susic G, et al. Health-related quality of life, anxiety, and depressive symptoms in children with primary immunodeficiencies. Patient Prefer Adherence. 2014;8:323–30.
20.
Byström IM, Hollén E, Fälth-Magnusson K, Johansson A. Health-related quality of life in children and adolescents with celiac disease: from the perspectives of children and parents. Gastroenterol Res Pract. 2012;2012:986475.CrossRefPubMedPubMedCentral
21.
Barrio J, Román E, Cilleruelo M, Márquez M, Mearin M, Fernández C. Health-related quality of life in spanish children with coeliac disease. J Pediatr Gastroenterol Nutr. 2016;62:603–8.
22.
Pico M, Spirito MF, Roizen M. Quality of life in children and adolescents with celiac disease: Argentinian version of the specific questionnaire CDDUX. Acta Gastroenterol Latinoam. 2012;42:12–9.PubMed
23.
Varni JW, Limbers CA, Burwinkle TM. Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL 4.0 generic Core scales. Health Qual Life Outcomes. 2007;5:43.CrossRefPubMedPubMedCentral
24.
Mazzone L, Reale L, Spina M, et al. Compliant gluten-free children with celiac disease: an evaluation of psychological distress. BMC Pediatr. 2011;11:46.
25.
Häuser W, Janke KH, Klump B, Gregor M, Hinz A. Anxiety and depression in adult patients with celiac disease on a gluten-free diet. World J Gastroenterol. 2010;16:2780–7.CrossRefPubMedPubMedCentral
26.
Ciacci C, Iavarone A, Siniscalchi M, Romano R, De Rosa A. Psychological dimensions of celiac disease: toward an integrated approach. Dig Dis Sci. 2002;47:2082–7.CrossRefPubMed
27.
Addolorato G. Anxiety but not depression decrease in celiac patients after one year gluten free diet: a longitudinal study. Scan J Gastroenterol. 2001;36:502–6.CrossRef
28.
Kolsteren MM, Koopman HM, Schalekamp G, Mearin ML. Health-related quality of life in children with celiac disease. J Pediatr. 2001;138:593–5.CrossRefPubMed
29.
Jellinek MS, Murphy JM, Little M, Pagano ME, Comer DM, Kelleher KJ. Use of the pediatric symptom checklist to screen for psychosocial problems in pediatric primary care. Arch Pediatr Adole Med. 1999;153:254–60.CrossRef
30.
Zarkadas M, Dubois S, MacIsaac K. Living with coeliac disease and a gluten-free diet: a Canadian perspective. J Hum Nutr Diet. 2013;26:10–23.
31.
Chauhan JC, Kumar P, Dutta AK, Basu S, Kumar A. Assessment of dietary compliance to gluten free diet and psychosocial problems in Indian children with celiac disease. Indian J Pediatr. 2010;77:649–54.CrossRefPubMed
32.
Stone K, Storey J, Hughes F. Perceived stress and comorbid illness predict depressive symptomatology in people with coeliac disease. Austral Psychol. 2012;47:198–203.CrossRef
33.
Black JL, Orfila C. Impact of coeliac disease on dietary habits and quality of life. J Hum Nutr Diet. 2011;24:582–7.CrossRefPubMed
34.
Addolorato G, Di Giuda D, De Rossi G, et al. Regional cerebral hypoperfusion in patients with celiac disease. Am J Med. 2004;116:312–7.CrossRefPubMed
35.
Solaymani-Dodaran M, West J, Logan RF. Long-term mortality in people with celiac disease diagnosed in childhood compared with adulthood: a population-based cohort study. Am J Gastroenterol. 2007;102:864–70.CrossRefPubMed
36.
White LE, Bannerman E, Gillett PM. Coeliac disease and the gluten-free diet: a review of the burdens; factors associated with adherence and impact on health-related quality of life, with specific focus on adolescence. J Hum Nutr Diet. 2016;29:593–606.CrossRefPubMed
37.
Di Filippo T, Orlando MF, Concialdi G, et al. The quality of life in developing age children with celiac disease. Minerva Pediatr. 2013;65:599–608.PubMed
Metadata
Title
Assessment of Quality of Life, Anxiety and Depressive Symptoms in Serbian Children with Celiac Disease and their Parents
Authors
Biljana Stojanović
Aleksandar Kočović
Nedeljko Radlović
Zoran Leković
Dragan Prokić
Nela Đonović
Stevan Jovanović
Biljana Vuletić
Publication date
01-05-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 5/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-018-2836-4

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