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Open Access 01-01-2018 | Review Article

Advances in ovarian cancer therapy

Authors: Alexander J. Cortez, Patrycja Tudrej, Katarzyna A. Kujawa, Katarzyna M. Lisowska

Published in: Cancer Chemotherapy and Pharmacology | Issue 1/2018

Abstract

Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of complete remissions; however, the recurrence rate is also high. For most patients, the disease eventually becomes a continuum of symptom-free periods and recurrence episodes. Different targeted treatment approaches and biological drugs, currently under development, bring the promise of turning ovarian cancer into a manageable chronic disease. In this review, we discuss the current standard in the therapy for ovarian cancer, major recent studies on the new variants of conventional therapies, and new therapeutic approaches, recently approved and/or in clinical trials. The latter include anti-angiogenic therapies, polyADP-ribose polymerase (PARP) inhibitors, inhibitors of growth factor signaling, or folate receptor inhibitors, as well as several immunotherapeutic approaches. We also discuss cost-effectiveness of some novel therapies and the issue of better selection of patients for personalized treatment.

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Title: Advances in ovarian cancer therapy
Authors: Alexander J. Cortez
Patrycja Tudrej
Katarzyna A. Kujawa
Katarzyna M. Lisowska
Publication date: 01-01-2018
Publisher: Springer Berlin Heidelberg
Published in: Cancer Chemotherapy and Pharmacology / Issue 1/2018
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-017-3501-8

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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