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Published in: Skeletal Radiology 8/2012

01-08-2012 | Review Article

Advanced imaging of skeletal manifestations of systemic mastocytosis

Authors: J. Fritz, E. K. Fishman, J. A. Carrino, M. S. Horger

Published in: Skeletal Radiology | Issue 8/2012

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Abstract

Systemic mastocytosis comprises a group of clonal disorders of the mast cell that most commonly involves the skeletal system. Imaging can be helpful in the detection and characterization of the osseous manifestations of this disease. While radiography and bone scans are frequently used for this assessment, low-dose multidetector computed tomography and magnetic resonance imaging can be more sensitive for the detection of marrow involvement and for the demonstration of the various disease patterns. In this article, we review the pathophysiological and clinical features of systemic mastocytosis, discuss the role of imaging for staging and management, and illustrate the various cross-sectional imaging appearances. Awareness and knowledge of the imaging features of this disorder will increase the accuracy of image interpretation and can contribute important information for management decisions.
Literature
1.
go back to reference Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, Metcalfe DD. Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood. 1999;94:2333–42.PubMed Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, Metcalfe DD. Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood. 1999;94:2333–42.PubMed
2.
3.
go back to reference Horny H, Metcalfe D, Bennett J, Bain B, Akin C, Escribano L. Mastocytosis. In: Swerdlow S, Campo E, Harris N, editors. WHO classification of tumors of hematopoietic and lymphoid tissues. Lyon: IARC Press; 2008. p. 54–63. Horny H, Metcalfe D, Bennett J, Bain B, Akin C, Escribano L. Mastocytosis. In: Swerdlow S, Campo E, Harris N, editors. WHO classification of tumors of hematopoietic and lymphoid tissues. Lyon: IARC Press; 2008. p. 54–63.
4.
go back to reference Valent P, Sperr WR, Schwartz LB, Horny HP. Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms. J Allergy Clin Immunol. 2004;114:3–11.PubMedCrossRef Valent P, Sperr WR, Schwartz LB, Horny HP. Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non-mast cell hematopoietic neoplasms. J Allergy Clin Immunol. 2004;114:3–11.PubMedCrossRef
5.
go back to reference Murali MR, Castells MC, Song JY, Dudzinski DM, Hasserjian RP. Case records of the Massachusetts General Hospital. Case 9-2011. A 37-year-old man with flushing and hypotension. N Engl J Med. 2011;364:1155–65.PubMedCrossRef Murali MR, Castells MC, Song JY, Dudzinski DM, Hasserjian RP. Case records of the Massachusetts General Hospital. Case 9-2011. A 37-year-old man with flushing and hypotension. N Engl J Med. 2011;364:1155–65.PubMedCrossRef
6.
go back to reference Zanotti R, Bonadonna P, Bonifacio M, Artuso A, Schena D, Rossini M, et al. Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis. Haematologica. 2011;96:482–4.PubMedCrossRef Zanotti R, Bonadonna P, Bonifacio M, Artuso A, Schena D, Rossini M, et al. Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis. Haematologica. 2011;96:482–4.PubMedCrossRef
7.
go back to reference Simpson JK, Metcalfe DD. Mastocytosis and disorders of mast cell proliferation. Clin Rev Allergy Immunol. 2002;22:175–88.PubMedCrossRef Simpson JK, Metcalfe DD. Mastocytosis and disorders of mast cell proliferation. Clin Rev Allergy Immunol. 2002;22:175–88.PubMedCrossRef
9.
go back to reference Travis WD, Li CY, Bergstralh EJ, Yam LT, Swee RG. Systemic mast cell disease. Analysis of 58 cases and literature review. Medicine (Baltimore). 1988;67:345–68. Travis WD, Li CY, Bergstralh EJ, Yam LT, Swee RG. Systemic mast cell disease. Analysis of 58 cases and literature review. Medicine (Baltimore). 1988;67:345–68.
10.
go back to reference Genovese A, Spadaro G, Triggiani M, Marone G. Clinical advances in mastocytosis. Int J Clin Lab Res. 1995;25:178–88.PubMedCrossRef Genovese A, Spadaro G, Triggiani M, Marone G. Clinical advances in mastocytosis. Int J Clin Lab Res. 1995;25:178–88.PubMedCrossRef
11.
go back to reference Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res. 2001;25:603–25.PubMedCrossRef Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res. 2001;25:603–25.PubMedCrossRef
12.
go back to reference Pardanani A, Lim KH, Lasho TL, Finke C, McClure RF, Li CY, et al. Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies. Blood. 2009;114:3769–72.PubMedCrossRef Pardanani A, Lim KH, Lasho TL, Finke C, McClure RF, Li CY, et al. Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies. Blood. 2009;114:3769–72.PubMedCrossRef
13.
go back to reference Parker RI. Hematologic aspects of systemic mastocytosis. Hematol Oncol Clin North Am. 2000;14:557–68.PubMedCrossRef Parker RI. Hematologic aspects of systemic mastocytosis. Hematol Oncol Clin North Am. 2000;14:557–68.PubMedCrossRef
14.
go back to reference Lim KH, Tefferi A, Lasho TL, Finke C, Patnaik M, Butterfield JH, et al. Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 2009;113:5727–36.PubMedCrossRef Lim KH, Tefferi A, Lasho TL, Finke C, Patnaik M, Butterfield JH, et al. Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 2009;113:5727–36.PubMedCrossRef
15.
go back to reference Barete S, Assous N, de Gennes C, Grandpeix C, Feger F, Palmerini F, et al. Systemic mastocytosis and bone involvement in a cohort of 75 patients. Ann Rheum Dis. 2010;69:1838–41.PubMedCrossRef Barete S, Assous N, de Gennes C, Grandpeix C, Feger F, Palmerini F, et al. Systemic mastocytosis and bone involvement in a cohort of 75 patients. Ann Rheum Dis. 2010;69:1838–41.PubMedCrossRef
16.
go back to reference Lawrence JB, Friedman BS, Travis WD, Chinchilli VM, Metcalfe DD, Gralnick HR. Hematologic manifestations of systemic mast cell disease: a prospective study of laboratory and morphologic features and their relation to prognosis. Am J Med. 1991;91:612–24.PubMedCrossRef Lawrence JB, Friedman BS, Travis WD, Chinchilli VM, Metcalfe DD, Gralnick HR. Hematologic manifestations of systemic mast cell disease: a prospective study of laboratory and morphologic features and their relation to prognosis. Am J Med. 1991;91:612–24.PubMedCrossRef
17.
go back to reference Johansson C, Roupe G, Lindstedt G, Mellstrom D. Bone density, bone markers and bone radiological features in mastocytosis. Age Ageing. 1996;25:1–7.PubMedCrossRef Johansson C, Roupe G, Lindstedt G, Mellstrom D. Bone density, bone markers and bone radiological features in mastocytosis. Age Ageing. 1996;25:1–7.PubMedCrossRef
18.
go back to reference Rafii M, Firooznia H, Golimbu C, Balthazar E. Pathologic fracture in systemic mastocytosis. Radiographic spectrum and review of the literature. Clin Orthop Relat Res. 1983;260–7. Rafii M, Firooznia H, Golimbu C, Balthazar E. Pathologic fracture in systemic mastocytosis. Radiographic spectrum and review of the literature. Clin Orthop Relat Res. 1983;260–7.
19.
go back to reference Rosenbaum RC, Frieri M, Metcalfe DD. Patterns of skeletal scintigraphy and their relationship to plasma and urinary histamine levels in systemic mastocytosis. J Nucl Med. 1984;25:859–64.PubMed Rosenbaum RC, Frieri M, Metcalfe DD. Patterns of skeletal scintigraphy and their relationship to plasma and urinary histamine levels in systemic mastocytosis. J Nucl Med. 1984;25:859–64.PubMed
20.
go back to reference Goldhaber P. Heparin enhancement of factors stimulating bone resorption in tissue culture. Science. 1965;147:407–8.PubMedCrossRef Goldhaber P. Heparin enhancement of factors stimulating bone resorption in tissue culture. Science. 1965;147:407–8.PubMedCrossRef
21.
22.
go back to reference Gospodarowicz D, Cheng J. Heparin protects basic and acidic FGF from inactivation. J Cell Physiol. 1986;128:475–84.PubMedCrossRef Gospodarowicz D, Cheng J. Heparin protects basic and acidic FGF from inactivation. J Cell Physiol. 1986;128:475–84.PubMedCrossRef
23.
go back to reference McKenna MJ, Frame B. The mast cell and bone. Clin Orthop Relat Res. 1985;226–33. McKenna MJ, Frame B. The mast cell and bone. Clin Orthop Relat Res. 1985;226–33.
24.
go back to reference Resnick D, Haghishi P. Lymphoproliferative and myeloproliferative disorders. In: Resnick D, editor. Diagnosis of bone and joint disorders. Philadelphia: Saunders; 2002. p. 2327–31. Resnick D, Haghishi P. Lymphoproliferative and myeloproliferative disorders. In: Resnick D, editor. Diagnosis of bone and joint disorders. Philadelphia: Saunders; 2002. p. 2327–31.
25.
go back to reference Floman Y, Amir G. Systemic mastocytosis presenting with severe spinal osteopenia and multiple compression fractures. J Spinal Disord. 1991;4:369–73.PubMedCrossRef Floman Y, Amir G. Systemic mastocytosis presenting with severe spinal osteopenia and multiple compression fractures. J Spinal Disord. 1991;4:369–73.PubMedCrossRef
26.
27.
go back to reference Sundaram M. Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 2009;38:841–53.PubMedCrossRef Sundaram M. Founders lecture 2007: Metabolic bone disease: what has changed in 30 years? Skeletal Radiol. 2009;38:841–53.PubMedCrossRef
28.
go back to reference Link TM. The Founder’s Lecture 2009: advances in imaging of osteoporosis and osteoarthritis. Skeletal Radiol. 2010;39:943–55.PubMedCrossRef Link TM. The Founder’s Lecture 2009: advances in imaging of osteoporosis and osteoarthritis. Skeletal Radiol. 2010;39:943–55.PubMedCrossRef
29.
go back to reference Ejindu VC, Hine AL, Mashayekhi M, Shorvon PJ, Misra RR. Musculoskeletal manifestations of sickle cell disease. Radiographics. 2007;27:1005–21.PubMedCrossRef Ejindu VC, Hine AL, Mashayekhi M, Shorvon PJ, Misra RR. Musculoskeletal manifestations of sickle cell disease. Radiographics. 2007;27:1005–21.PubMedCrossRef
30.
go back to reference Katz R, Booth T, Hargunani R, Wylie P, Holloway B. Radiological aspects of Gaucher disease. Skeletal Radiol. 2011;40:1505–13.PubMedCrossRef Katz R, Booth T, Hargunani R, Wylie P, Holloway B. Radiological aspects of Gaucher disease. Skeletal Radiol. 2011;40:1505–13.PubMedCrossRef
31.
go back to reference Sebes JI, Niell HB, Palmieri GM, Reidy TJ. Skeletal surveys in multiple myeloma. Radiologic-clinical correlation. Skeletal Radiol. 1986;15:354–9.PubMedCrossRef Sebes JI, Niell HB, Palmieri GM, Reidy TJ. Skeletal surveys in multiple myeloma. Radiologic-clinical correlation. Skeletal Radiol. 1986;15:354–9.PubMedCrossRef
32.
go back to reference Horger M, Kanz L, Denecke B, Vonthein R, Pereira P, Claussen CD, et al. The benefit of using whole-body, low-dose, nonenhanced, multidetector computed tomography for follow-up and therapy response monitoring in patients with multiple myeloma. Cancer. 2007;109:1617–26.PubMedCrossRef Horger M, Kanz L, Denecke B, Vonthein R, Pereira P, Claussen CD, et al. The benefit of using whole-body, low-dose, nonenhanced, multidetector computed tomography for follow-up and therapy response monitoring in patients with multiple myeloma. Cancer. 2007;109:1617–26.PubMedCrossRef
33.
go back to reference Tunaci M, Tunaci A, Engin G, Ozkorkmaz B, Dincol G, Acunas G, et al. Imaging features of thalassemia. Eur Radiol. 1999;9:1804–9.PubMedCrossRef Tunaci M, Tunaci A, Engin G, Ozkorkmaz B, Dincol G, Acunas G, et al. Imaging features of thalassemia. Eur Radiol. 1999;9:1804–9.PubMedCrossRef
34.
go back to reference Bieler EU, Wohlenberg H, Utech C. Skeletal manifestations of generalized mastocytosis in the skeletal scintigram compared with roentgen findings. Rofo. 1985;142:552–8.PubMedCrossRef Bieler EU, Wohlenberg H, Utech C. Skeletal manifestations of generalized mastocytosis in the skeletal scintigram compared with roentgen findings. Rofo. 1985;142:552–8.PubMedCrossRef
35.
go back to reference Huang TY, Yam LT, Li CY. Radiological features of systemic mast-cell disease. Br J Radiol. 1987;60:765–70.PubMedCrossRef Huang TY, Yam LT, Li CY. Radiological features of systemic mast-cell disease. Br J Radiol. 1987;60:765–70.PubMedCrossRef
36.
go back to reference Bancroft LW, Berquist TH. Erdheim-Chester disease: radiographic findings in five patients. Skeletal Radiol. 1998;27:127–32.PubMedCrossRef Bancroft LW, Berquist TH. Erdheim-Chester disease: radiographic findings in five patients. Skeletal Radiol. 1998;27:127–32.PubMedCrossRef
37.
go back to reference Baskin Jr HJ. The pathogenesis and imaging of the tuberous sclerosis complex. Pediatr Radiol. 2008;38:936–52.PubMedCrossRef Baskin Jr HJ. The pathogenesis and imaging of the tuberous sclerosis complex. Pediatr Radiol. 2008;38:936–52.PubMedCrossRef
38.
go back to reference Guermazi A, de Kerviller E, Cazals-Hatem D, Zagdanski AM, Frija J. Imaging findings in patients with myelofibrosis. Eur Radiol. 1999;9:1366–75.PubMedCrossRef Guermazi A, de Kerviller E, Cazals-Hatem D, Zagdanski AM, Frija J. Imaging findings in patients with myelofibrosis. Eur Radiol. 1999;9:1366–75.PubMedCrossRef
39.
go back to reference Mithal A, Trivedi N, Gupta SK, Kumar S, Gupta RK. Radiological spectrum of endemic fluorosis: relationship with calcium intake. Skeletal Radiol. 1993;22:257–61.PubMedCrossRef Mithal A, Trivedi N, Gupta SK, Kumar S, Gupta RK. Radiological spectrum of endemic fluorosis: relationship with calcium intake. Skeletal Radiol. 1993;22:257–61.PubMedCrossRef
40.
go back to reference Mirra JM, Brien EW, Tehranzadeh J. Paget’s disease of bone: review with emphasis on radiologic features. II. Skeletal Radiol. 1995;24:173–84.PubMed Mirra JM, Brien EW, Tehranzadeh J. Paget’s disease of bone: review with emphasis on radiologic features. II. Skeletal Radiol. 1995;24:173–84.PubMed
41.
go back to reference Mirra JM, Brien EW, Tehranzadeh J. Paget’s disease of bone: review with emphasis on radiologic features. I. Skeletal Radiol. 1995;24:163–71.PubMed Mirra JM, Brien EW, Tehranzadeh J. Paget’s disease of bone: review with emphasis on radiologic features. I. Skeletal Radiol. 1995;24:163–71.PubMed
42.
go back to reference Burgener FA, Perry PE. Solitary renal cell carcinoma metastasis in Paget’s disease simulating sarcomatous degeneration. AJR Am J Roentgenol. 1977;128:853–5.PubMed Burgener FA, Perry PE. Solitary renal cell carcinoma metastasis in Paget’s disease simulating sarcomatous degeneration. AJR Am J Roentgenol. 1977;128:853–5.PubMed
43.
go back to reference Dell’Atti C, Cassar-Pullicino VN, Lalam RK, Tins BJ, Tyrrell PN. The spine in Paget’s disease. Skeletal Radiol. 2007;36:609–26.PubMedCrossRef Dell’Atti C, Cassar-Pullicino VN, Lalam RK, Tins BJ, Tyrrell PN. The spine in Paget’s disease. Skeletal Radiol. 2007;36:609–26.PubMedCrossRef
45.
go back to reference Graves III L, Stechschulte DJ, Morris DC, Lukert BP. Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes. J Bone Miner Res. 1990;5:1113–9.PubMedCrossRef Graves III L, Stechschulte DJ, Morris DC, Lukert BP. Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes. J Bone Miner Res. 1990;5:1113–9.PubMedCrossRef
46.
go back to reference Chen CC, Andrich MP, Mican JM, Metcalfe DD. A retrospective analysis of bone scan abnormalities in mastocytosis: correlation with disease category and prognosis. J Nucl Med. 1994;35:1471–5.PubMed Chen CC, Andrich MP, Mican JM, Metcalfe DD. A retrospective analysis of bone scan abnormalities in mastocytosis: correlation with disease category and prognosis. J Nucl Med. 1994;35:1471–5.PubMed
47.
go back to reference Ho LM, Lipper MH. Mastocytosis of the axial skeleton presenting as an epidural mass lesion: MR imaging appearance. AJR Am J Roentgenol. 1996;167:716–8.PubMed Ho LM, Lipper MH. Mastocytosis of the axial skeleton presenting as an epidural mass lesion: MR imaging appearance. AJR Am J Roentgenol. 1996;167:716–8.PubMed
48.
go back to reference Gleeson TG, Moriarty J, Shortt CP, Gleeson JP, Fitzpatrick P, Byrne B, et al. Accuracy of whole-body low-dose multidetector CT (WBLDCT) versus skeletal survey in the detection of myelomatous lesions, and correlation of disease distribution with whole-body MRI (WBMRI). Skeletal Radiol. 2009;38:225–36.PubMedCrossRef Gleeson TG, Moriarty J, Shortt CP, Gleeson JP, Fitzpatrick P, Byrne B, et al. Accuracy of whole-body low-dose multidetector CT (WBLDCT) versus skeletal survey in the detection of myelomatous lesions, and correlation of disease distribution with whole-body MRI (WBMRI). Skeletal Radiol. 2009;38:225–36.PubMedCrossRef
49.
go back to reference Kropil P, Fenk R, Fritz LB, Blondin D, Kobbe G, Modder U, et al. Comparison of whole-body 64-slice multidetector computed tomography and conventional radiography in staging of multiple myeloma. Eur Radiol. 2008;18:51–8.PubMedCrossRef Kropil P, Fenk R, Fritz LB, Blondin D, Kobbe G, Modder U, et al. Comparison of whole-body 64-slice multidetector computed tomography and conventional radiography in staging of multiple myeloma. Eur Radiol. 2008;18:51–8.PubMedCrossRef
50.
go back to reference Mahnken AH, Wildberger JE, Gehbauer G, Schmitz-Rode T, Blaum M, Fabry U, et al. Multidetector CT of the spine in multiple myeloma: comparison with MR imaging and radiography. AJR Am J Roentgenol. 2002;178:1429–36.PubMed Mahnken AH, Wildberger JE, Gehbauer G, Schmitz-Rode T, Blaum M, Fabry U, et al. Multidetector CT of the spine in multiple myeloma: comparison with MR imaging and radiography. AJR Am J Roentgenol. 2002;178:1429–36.PubMed
51.
go back to reference Avila NA, Ling A, Metcalfe DD, Worobec AS. Mastocytosis: magnetic resonance imaging patterns of marrow disease. Skeletal Radiol. 1998;27:119–26.PubMedCrossRef Avila NA, Ling A, Metcalfe DD, Worobec AS. Mastocytosis: magnetic resonance imaging patterns of marrow disease. Skeletal Radiol. 1998;27:119–26.PubMedCrossRef
52.
go back to reference Avila NA, Ling A, Worobec AS, Mican JM, Metcalfe DD. Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 1997;202:367–72.PubMed Avila NA, Ling A, Worobec AS, Mican JM, Metcalfe DD. Systemic mastocytosis: CT and US features of abdominal manifestations. Radiology. 1997;202:367–72.PubMed
53.
go back to reference Horger M, Claussen CD, Bross-Bach U, Vonthein R, Trabold T, Heuschmid M, et al. Whole-body low-dose multidetector row-CT in the diagnosis of multiple myeloma: an alternative to conventional radiography. Eur J Radiol. 2005;54:289–97.PubMedCrossRef Horger M, Claussen CD, Bross-Bach U, Vonthein R, Trabold T, Heuschmid M, et al. Whole-body low-dose multidetector row-CT in the diagnosis of multiple myeloma: an alternative to conventional radiography. Eur J Radiol. 2005;54:289–97.PubMedCrossRef
54.
go back to reference Roca M, Mota J, Giraldo P, Garcia Erce JA. Systemic mastocytosis: MRI of bone marrow involvement. Eur Radiol. 1999;9:1094–7.PubMedCrossRef Roca M, Mota J, Giraldo P, Garcia Erce JA. Systemic mastocytosis: MRI of bone marrow involvement. Eur Radiol. 1999;9:1094–7.PubMedCrossRef
55.
go back to reference Haney K, Russell W, Raila FA, Brower AC, Harrison RB. MRI characteristics of systemic mastocytosis of the lumbosacral spine. Skeletal Radiol. 1996;25:171–3.PubMedCrossRef Haney K, Russell W, Raila FA, Brower AC, Harrison RB. MRI characteristics of systemic mastocytosis of the lumbosacral spine. Skeletal Radiol. 1996;25:171–3.PubMedCrossRef
56.
go back to reference Hwang S, Panicek DM. Magnetic resonance imaging of bone marrow in oncology. I. Skeletal Radiol. 2007;36:913–20.PubMedCrossRef Hwang S, Panicek DM. Magnetic resonance imaging of bone marrow in oncology. I. Skeletal Radiol. 2007;36:913–20.PubMedCrossRef
57.
go back to reference Khoo MM, Tyler PA, Saifuddin A, Padhani AR. Diffusion-weighted imaging (DWI) in musculoskeletal MRI: a critical review. Skeletal Radiol. 2011;40:665–81.PubMedCrossRef Khoo MM, Tyler PA, Saifuddin A, Padhani AR. Diffusion-weighted imaging (DWI) in musculoskeletal MRI: a critical review. Skeletal Radiol. 2011;40:665–81.PubMedCrossRef
58.
go back to reference Bartuseviciene A, Samuilis A, Skucas J. Camurati-Engelmann disease: imaging, clinical features and differential diagnosis. Skeletal Radiol. 2009;38:1037–43.PubMedCrossRef Bartuseviciene A, Samuilis A, Skucas J. Camurati-Engelmann disease: imaging, clinical features and differential diagnosis. Skeletal Radiol. 2009;38:1037–43.PubMedCrossRef
59.
go back to reference Schmidt GP, Reiser MF, Baur-Melnyk A. Whole-body imaging of the musculoskeletal system: the value of MR imaging. Skeletal Radiol. 2007;36:1109–19.PubMedCrossRef Schmidt GP, Reiser MF, Baur-Melnyk A. Whole-body imaging of the musculoskeletal system: the value of MR imaging. Skeletal Radiol. 2007;36:1109–19.PubMedCrossRef
60.
go back to reference Chavhan GB, Babyn PS. Whole-body MR imaging in children: principles, technique, current applications, and future directions. Radiographics. 2011;31:1757–72.PubMedCrossRef Chavhan GB, Babyn PS. Whole-body MR imaging in children: principles, technique, current applications, and future directions. Radiographics. 2011;31:1757–72.PubMedCrossRef
61.
go back to reference Bauerle T, Hillengass J, Fechtner K, Zechmann CM, Grenacher L, Moehler TM, et al. Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging. Radiology. 2009;252:477–85.PubMedCrossRef Bauerle T, Hillengass J, Fechtner K, Zechmann CM, Grenacher L, Moehler TM, et al. Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging. Radiology. 2009;252:477–85.PubMedCrossRef
62.
go back to reference Zettinig G, Becherer A, Szabo M, Uffmann M, Dudczak R, Valent P, et al. FDG positron emission tomography in patients with systemic mastocytosis. AJR Am J Roentgenol. 2002;179:1235–7.PubMed Zettinig G, Becherer A, Szabo M, Uffmann M, Dudczak R, Valent P, et al. FDG positron emission tomography in patients with systemic mastocytosis. AJR Am J Roentgenol. 2002;179:1235–7.PubMed
63.
go back to reference Tomihama RT, McEachen JC, Kuo PH. Imaging of systemic mastocytosis by FDG-PET/CT demonstrates increased activity in cortical bone. Clin Nucl Med. 2008;33:220–3.PubMedCrossRef Tomihama RT, McEachen JC, Kuo PH. Imaging of systemic mastocytosis by FDG-PET/CT demonstrates increased activity in cortical bone. Clin Nucl Med. 2008;33:220–3.PubMedCrossRef
Metadata
Title
Advanced imaging of skeletal manifestations of systemic mastocytosis
Authors
J. Fritz
E. K. Fishman
J. A. Carrino
M. S. Horger
Publication date
01-08-2012
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 8/2012
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-012-1374-9

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