Published in:
01-08-2017 | Editorial
Advanced Hodgkin’s lymphoma: End-of-treatment FDG-PET should be maintained
Authors:
Elif Hindié, Charles Mesguich, Krimo Bouabdallah, Noël Milpied
Published in:
European Journal of Nuclear Medicine and Molecular Imaging
|
Issue 8/2017
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Excerpt
Positron emission tomography with
18F–fluorodeoxyglucose (FDG-PET) has become a cornerstone procedure in the modern management of Hodgkin’s lymphoma (HL) [
1‐
4]. It offers better initial staging and risk stratification [
3]. FDG-PET often detects occult extranodal disease, notably focal bone marrow lesions [
5‐
7]. It rendered useless routine bone marrow biopsy [
3]. HL is associated with a high rate of residual masses at the end of therapy, which are difficult to characterize as residual disease or not on conventional imaging. Therefore, a major milestone was the finding that end-of-treatment FDG-PET offers excellent prediction of progression-free-survival (PFS), even in the presence of a residual mass [
8‐
11]. This finding led to the introduction of FDG-PET imaging in response criteria for HL [
12]. …