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Cancer Causes & Control
Published in: Cancer Causes & Control 7/2011

01-07-2011 | Original paper

Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis

Authors: Yeon Ji Lee, Seung-Kwon Myung, BeLong Cho, Byung-Joo Park, Jin Ho Park, Woong Ju, Min-Sun Park, Ji-Ho Choi

Published in: Cancer Causes & Control | Issue 7/2011

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Abstract

Objective

The findings from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous polyps are inconsistent. We performed a meta-analysis of epidemiological studies including cross-sectional, case–control, and cohort studies.

Methods

We searched PubMed and EMBASE in June, 2010. All searched articles were reviewed and selected independently by two evaluators according to pre-determined selection criteria.

Results

We included 25 studies (nine cross-sectional studies, eleven case–control studies, and five prospective cohort studies) that comprised a total of 300,671 participants and 20,903 cases in the final analysis. When all studies were pooled, the odds ratio (OR) or relative risk (RR) of adiposity and abdominal adiposity for colorectal adenomatous polyp risk was 1.43 (95% confidence interval (CI) 1.23–1.67; n = 22) and 1.42 (95% CI 1.30–1.56; n = 12), respectively. Similarly, an increased risk of colorectal adenomatous polyps was observed in most of the subgroup meta-analyses.

Conclusions

Overall, we found that adiposity and abdominal adiposity significantly increased the risk of colorectal adenomatous polyps in a meta-analysis of epidemiological studies.
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Metadata
Title
Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis
Authors
Yeon Ji Lee
Seung-Kwon Myung
BeLong Cho
Byung-Joo Park
Jin Ho Park
Woong Ju
Min-Sun Park
Ji-Ho Choi
Publication date
01-07-2011
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 7/2011
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-011-9777-9

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