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01-10-2009 | OriginalPaper

Adiposity in relation to colorectal adenomas and hyperplastic polyps in women

Authors: Michael F. Leitzmann, Andrew Flood, Leah M. Ferrucci, Philip Schoenfeld, Brooks Cash, Arthur Schatzkin, Amanda J. Cross

Published in: Cancer Causes & Control | Issue 8/2009

Abstract

Objective

To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps.

Methods

We conducted a cross-sectional study among 1,420 asymptomatic women aged 40–79 years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps.

Results

We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women = 1.57; 95% CI = 1.07–2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR = 3.76; 95% CI = 2.35–6.01) and the combination of adenomas and hyperplastic polyps (OR = 2.84; 95% CI = 1.41–5.72).

Conclusions

Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer.

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Title: Adiposity in relation to colorectal adenomas and hyperplastic polyps in women
Authors: Michael F. Leitzmann
Andrew Flood
Leah M. Ferrucci
Philip Schoenfeld
Brooks Cash
Arthur Schatzkin
Amanda J. Cross
Publication date: 01-10-2009
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 8/2009
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-009-9346-7

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