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Published in: BMC Pediatrics 1/2018

Open Access 01-12-2018 | Research article

Adherence to guidelines for testing and treatment of children with pharyngitis: a retrospective study

Authors: Thea Brennan-Krohn, Al Ozonoff, Thomas J. Sandora

Published in: BMC Pediatrics | Issue 1/2018

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Abstract

Background

Group A streptococcus (GAS) is the most common bacterial etiology of pharyngitis but is difficult to distinguish clinically from viral pharyngitis. There are benefits to early antibacterial treatment of GAS pharyngitis, but administering antibiotics to children with viral pharyngitis is ineffective and costly. We evaluated adherence to guidelines that were developed to help clinicians distinguish between viral and GAS pharyngitis and guide management.

Methods

Retrospective cohort study of patients ages 3–18 who had a rapid streptococcal test and/or throat culture performed in an outpatient setting. We collected data on documentation of components of the McIsaac score and classified tests as indicated if the score was ≥2. Based on McIsaac score and GAS test results, we determined whether each antibiotic course prescribed was indicated according to the Infectious Diseases Society of America guideline.

Results

Among 291 eligible children, 87 (30%) had all five components of the McIsaac score documented. There was sufficient data to classify the score as either < 2 or ≥2 in 234 (80%); among these, 96% of tests were indicated. Twenty-nine patients (10%) were prescribed antibiotics. Eight (28%) of these prescriptions were not indicated according to guidelines.

Conclusions

The majority of GAS tests in children with pharyngitis are indicated, although providers do not regularly document all elements of a validated pharyngitis scoring tool. Over one quarter of children prescribed antibiotics for pharyngitis did not require antibiotics according to guidelines. There remains a role for targeted antimicrobial stewardship education regarding pharyngitis management in pediatric outpatient settings.
Literature
1.
go back to reference Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010;126:e557–64.CrossRefPubMed Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010;126:e557–64.CrossRefPubMed
2.
go back to reference Kronman MP, Zhou C, Mangione-Smith R. Bacterial prevalence and antimicrobial prescribing trends for acute respiratory tract infections. Pediatrics. 2014;134:e956–65.CrossRefPubMed Kronman MP, Zhou C, Mangione-Smith R. Bacterial prevalence and antimicrobial prescribing trends for acute respiratory tract infections. Pediatrics. 2014;134:e956–65.CrossRefPubMed
3.
go back to reference Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat (review). Cochrane Database Syst Rev. 2013;11:CD000023. Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat (review). Cochrane Database Syst Rev. 2013;11:CD000023.
4.
go back to reference Gerber MA, Baltimore RS, Eaton CB, Gewitz M, Rowley AH, Shulman ST, et al. Prevention of rheumatic fever and diagnosis and treatment of acute streptococcal pharyngitis. Circulation. 2009;119:1541–51.CrossRefPubMed Gerber MA, Baltimore RS, Eaton CB, Gewitz M, Rowley AH, Shulman ST, et al. Prevention of rheumatic fever and diagnosis and treatment of acute streptococcal pharyngitis. Circulation. 2009;119:1541–51.CrossRefPubMed
5.
go back to reference Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, et al. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:155–64.CrossRefPubMed Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, et al. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:155–64.CrossRefPubMed
6.
go back to reference Wald ER, Green MD, Schwartz B, Barbadora K. A streptococcal score card revisited. Pediatr Emerg Care. 1998;14:109–11.CrossRefPubMed Wald ER, Green MD, Schwartz B, Barbadora K. A streptococcal score card revisited. Pediatr Emerg Care. 1998;14:109–11.CrossRefPubMed
7.
go back to reference Breese BB. A simple scorecard for the tentative diagnosis of streptococcal pharyngitis. Am J Dis Child. 1977;131:514–7.PubMed Breese BB. A simple scorecard for the tentative diagnosis of streptococcal pharyngitis. Am J Dis Child. 1977;131:514–7.PubMed
8.
go back to reference Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Mak. 1981;1:239–46.CrossRef Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K. The diagnosis of strep throat in adults in the emergency room. Med Decis Mak. 1981;1:239–46.CrossRef
9.
go back to reference WJ MI, White D, Tannenbaum D, Low DE. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. CMAJ. 1998;158:75–83. WJ MI, White D, Tannenbaum D, Low DE. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. CMAJ. 1998;158:75–83.
10.
11.
go back to reference Tanz R, Shulman ST. Chronic pharyngeal carriage of group a streptococci. Pediatr Infect Dis J. 2007;26:175–6.CrossRefPubMed Tanz R, Shulman ST. Chronic pharyngeal carriage of group a streptococci. Pediatr Infect Dis J. 2007;26:175–6.CrossRefPubMed
12.
go back to reference Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, et al. Clinical practice guideline for the diagnosis and management of group a streptococcal pharyngitis: 2012 update by the infectious diseases society of America. Clin Infect Dis. 2012;55(10):1279–82.CrossRefPubMed Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, et al. Clinical practice guideline for the diagnosis and management of group a streptococcal pharyngitis: 2012 update by the infectious diseases society of America. Clin Infect Dis. 2012;55(10):1279–82.CrossRefPubMed
13.
go back to reference American Academy of Pediatrics. Group A streptococcal infections. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2012 Report of the Committee on Infectious Diseases. Elk Grove Village: American Academy of Pediatrics; 2012:668–80. American Academy of Pediatrics. Group A streptococcal infections. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2012 Report of the Committee on Infectious Diseases. Elk Grove Village: American Academy of Pediatrics; 2012:668–80.
14.
go back to reference Linder J, Bates D, Lee G, Finkelstein J. Antibiotic treatment of children with sore throat. JAMA. 2005;294:2315–22.CrossRefPubMed Linder J, Bates D, Lee G, Finkelstein J. Antibiotic treatment of children with sore throat. JAMA. 2005;294:2315–22.CrossRefPubMed
15.
go back to reference Benin AL, Vitkauskas G, Thornquist E, Shiffman RN, Concato J, Krumholz HM, et al. Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record. Pediatr Infect Dis J. 2003;22:1043–7.CrossRefPubMed Benin AL, Vitkauskas G, Thornquist E, Shiffman RN, Concato J, Krumholz HM, et al. Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record. Pediatr Infect Dis J. 2003;22:1043–7.CrossRefPubMed
17.
go back to reference Albrich WC, Monnet DL, Harbarth S. Antibiotic selection pressure and resistance in Streptococcus Pneumoniae and streptococcus pyogenes. Emerg Infect Dis. 2004;10:514–7.CrossRefPubMedPubMedCentral Albrich WC, Monnet DL, Harbarth S. Antibiotic selection pressure and resistance in Streptococcus Pneumoniae and streptococcus pyogenes. Emerg Infect Dis. 2004;10:514–7.CrossRefPubMedPubMedCentral
18.
go back to reference Hersh AL, Jackson MA, Hicks LA. Principles of judicious antibiotic prescribing for bacterial upper respiratory tract infections in pediatrics. Pediatrics. 2013;132:1146–54.CrossRefPubMed Hersh AL, Jackson MA, Hicks LA. Principles of judicious antibiotic prescribing for bacterial upper respiratory tract infections in pediatrics. Pediatrics. 2013;132:1146–54.CrossRefPubMed
19.
20.
21.
go back to reference Moro ML, Marchi M, Gagliotti C, Di Mario S, Resi D. Why do paediatricians prescribe antibiotics? Results of an Italian regional project. BMC Pediatr. 2009;9:69.CrossRefPubMedPubMedCentral Moro ML, Marchi M, Gagliotti C, Di Mario S, Resi D. Why do paediatricians prescribe antibiotics? Results of an Italian regional project. BMC Pediatr. 2009;9:69.CrossRefPubMedPubMedCentral
22.
go back to reference Linder JA, Chan JC, Bates DW. Evaluation and treatment of pharyngitis in primary care practice - the difference between guidelines is largely academic. Arch Intern Med. 2006;166:1374–9.CrossRefPubMed Linder JA, Chan JC, Bates DW. Evaluation and treatment of pharyngitis in primary care practice - the difference between guidelines is largely academic. Arch Intern Med. 2006;166:1374–9.CrossRefPubMed
23.
go back to reference Dooling KL, Shapiro DJ, Van Beneden C, Hersh AL, Hicks LA. Overprescribing and inappropriate antibiotic selection for children with pharyngitis in the United States, 1997-2010. JAMA Pediatr. 2014;168:1073–4.CrossRefPubMed Dooling KL, Shapiro DJ, Van Beneden C, Hersh AL, Hicks LA. Overprescribing and inappropriate antibiotic selection for children with pharyngitis in the United States, 1997-2010. JAMA Pediatr. 2014;168:1073–4.CrossRefPubMed
24.
go back to reference Gerber MA. Comparison of throat cultures and rapid strep tests for diagnosis of streptococcal pharyngitis. Pediatr Infect Dis J. 1989;8:820–4.CrossRefPubMed Gerber MA. Comparison of throat cultures and rapid strep tests for diagnosis of streptococcal pharyngitis. Pediatr Infect Dis J. 1989;8:820–4.CrossRefPubMed
25.
go back to reference WHO. Rheumatic fever and rheumatic heart disease. World Health Organ Tech Rep Ser. 2004;923:1–122. WHO. Rheumatic fever and rheumatic heart disease. World Health Organ Tech Rep Ser. 2004;923:1–122.
26.
go back to reference Miyake CY, Gauvreau K, Tani LY, Sundel RP, Newburger JW. Characteristics of children discharged from hospitals in the United States in 2000 with the diagnosis of acute rheumatic fever. Pediatrics. 2007;120:503–8.CrossRefPubMed Miyake CY, Gauvreau K, Tani LY, Sundel RP, Newburger JW. Characteristics of children discharged from hospitals in the United States in 2000 with the diagnosis of acute rheumatic fever. Pediatrics. 2007;120:503–8.CrossRefPubMed
27.
go back to reference Ebell MH, Smith MA, Barry HC, Ives K, Carey M. The rational clinical examination. Does this patient have strep throat? JAMA. 2000;284:2912–8.CrossRefPubMed Ebell MH, Smith MA, Barry HC, Ives K, Carey M. The rational clinical examination. Does this patient have strep throat? JAMA. 2000;284:2912–8.CrossRefPubMed
28.
go back to reference Vaz LE, Kleinman KP, Raebel MA, Nordin JD, Lakoma MD, Dutta-Linn MM, et al. Recent trends in outpatient antibiotic use in children. Pediatrics. 2014;133:375–85.CrossRefPubMedPubMedCentral Vaz LE, Kleinman KP, Raebel MA, Nordin JD, Lakoma MD, Dutta-Linn MM, et al. Recent trends in outpatient antibiotic use in children. Pediatrics. 2014;133:375–85.CrossRefPubMedPubMedCentral
29.
go back to reference Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. J Am Med Assoc. 2009;302:758–66.CrossRef Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. J Am Med Assoc. 2009;302:758–66.CrossRef
30.
go back to reference McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA. 2002;287:3096–102.CrossRefPubMed McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA. 2002;287:3096–102.CrossRefPubMed
31.
go back to reference Shulman ST, Tanz RR. Group a streptococcal pharyngitis and immune-mediated complications: from diagnosis to management. Expert Rev Anti-Infect Ther. 2010;8:137–50.CrossRefPubMed Shulman ST, Tanz RR. Group a streptococcal pharyngitis and immune-mediated complications: from diagnosis to management. Expert Rev Anti-Infect Ther. 2010;8:137–50.CrossRefPubMed
Metadata
Title
Adherence to guidelines for testing and treatment of children with pharyngitis: a retrospective study
Authors
Thea Brennan-Krohn
Al Ozonoff
Thomas J. Sandora
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2018
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-018-0988-z

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