Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Virology Journal
Published in: Virology Journal 1/2023

Open Access 01-12-2023 | Adenovirus | Research

Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary

Authors: Danielle T Cupido, Corena de Beer

Published in: Virology Journal | Issue 1/2023

Login to get access

Abstract

Sudden and unexpected death in infancy (SUDI) may be triggered by an external risk or exposure. Intestinal infections with enteric viruses may disrupt the gut and enhance bacterial toxins present in SUDI cases. While diarrhoeal disease deaths have decreased worldwide, approximately half a million deaths still occur in children in Sub- Saharan Africa and South Asia. Furthermore, the role of viral enteropathogens in SUDI cases have not been investigated. The aim of this study was to describe specific viral pathogens in stool samples collected from SUDI cases and age-matched, apparently healthy infants in Cape Town, South Africa. Stool samples were collected from 176 SUDI cases between June 2017 and May 2018. In addition, stool samples were collected from the nappies of 30 age-matched, apparently healthy infants as a control group. Real-time polymerase chain reaction was performed on the stool samples for viral detection. A total of 111 SUDI cases were positive for viruses, with rotavirus (38.6%; 68/176) and norovirus GI and GII (30.0%; 53/176) were prevalent in SUDI cases. Adenovirus Type F was present in only 15.9% (28/176), astrovirus in 9.7% (17/176), and sapovirus in 0.6% (1/176) of cases. In the control samples, norovirus GII was detected most frequently (36.7%; 11/30), followed by rotavirus (33.3%; 10/30), and sapovirus in 6.7% (2/30). While there was no significant association between SUDI cases and enteric viruses, the majority of viruses were significantly associated with the seasons. The study confirms the importance of rotavirus vaccination and describes the significance of norovirus infection in children, post rotavirus vaccine introduction.
Appendix
Available only for authorised users
Literature
1.
Fleming PJ, Blair PS, Pease A. Sudden unexpected death in infancy: aetiology, pathophysiology, epidemiology and prevention in 2015. Arch Dis Child. 2015;100(10):984–8.PubMedCrossRef
2.
Weber MA, Sebire NJ. Postmortem investigation of sudden unexpected death in infancy: current issues and autopsy protocol. Diagn Histopathol. 2009;15(11):510–23.CrossRef
3.
Krous HF, Beckwith JB, Byard RW, Rognum TO, Bajanowski T, Corey T, Cutz E, Hanzlick R, Keens TG, Mitchell EA. Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach. Pediatrics. 2004;114(1):234-8. https://​doi.​org/​10.​1542/​peds.​114.​1.​234. PMID: 15231934.
4.
Filiano JJ, Kinney HC. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Biol Neonate. 1994;65(3–4):194–7.PubMedCrossRef
5.
6.
Goldstein RD, Kinney HC, Willinger M. Sudden unexpected death in fetal life through early childhood. Pediatrics. 2016;137(6).
7.
Duncan JR, Byard RW, editors. SIDS Sudden Infant and early childhood death: the past, the Present and the future. Adelaide (AU): University of Adelaide Press; 2018 May.
8.
9.
10.
Dattani S, Spooner F, Ritchie H, Roser M. Diarrheal Diseases. Our World in Data. 2023 Jul 3.
11.
Graves NS. Acute gastroenteritis. Prim care: Clin Office Pract. 2013;40(3):727–41.CrossRef
12.
Boschi-Pinto C, Velebit L, Shibuya K. Estimating child mortality due to Diarrhoea in developing countries. Bull World Health Organ. 2008;86(9):710–7.PubMedPubMedCentralCrossRef
13.
14.
15.
16.
Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, Panchalingam S, Wu Y, Sow SO, Sur D, Breiman RF, Faruque AS. Burden and aetiology of diarrhoeal Disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet. 2013;382(9888):209–22.PubMedCrossRef
17.
Janko MM, Joffe J, Michael D, Earl L, Rosettie KL, Sparks GW, Albertson SB, Compton K, Velandia PP, Stafford L, Zheng P. Cost-effectiveness of rotavirus vaccination in children under five years of age in 195 countries: a meta-regression analysis. Vaccine. 2022;40(28):3903–17.PubMedPubMedCentralCrossRef
18.
Tate JE, Burton AH, Boschi-Pinto C, Parashar UD, World Health Organization–Coordinated Global Rotavirus Surveillance Network, Agocs M, Serhan F, de Oliveira L, Mwenda JM, Mihigo R, Ranjan Wijesinghe P. Global, regional, and national estimates of rotavirus mortality in children < 5 years of age, 2000–2013. Clin Infect Dis. 2016;62(suppl2):96–105.CrossRef
19.
Burnett E, Jonesteller CL, Tate JE, Yen C, Parashar UD. Global impact of rotavirus vaccination on childhood hospitalizations and mortality from diarrhea. J Infect Dis. 2017;215(11):1666–72.PubMedCrossRef
20.
Hemming M, Räsänen S, Huhti L, Paloniemi M, Salminen M, Vesikari T. Major reduction of rotavirus, but not norovirus, gastroenteritis in children seen in hospital after the introduction of RotaTeq vaccine into the National Immunization Programme in Finland. Eur J Pediatr. 2013;172(6):739–46.PubMedPubMedCentralCrossRef
21.
Payne DC, Vinjé J, Szilagyi PG, Edwards KM, Staat MA, Weinberg GA, Hall CB, Chappell J, Bernstein DI, Curns AT, Wikswo M. Norovirus and medically attended gastroenteritis in US children. N Engl J Med. 2013;368(12):1121–30.PubMedPubMedCentralCrossRef
22.
23.
Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MP. Updated classification of norovirus genogroups and genotypes. J Gen Virol. 2019;100(10):1393.PubMedPubMedCentralCrossRef
24.
25.
Bucardo F, Reyes Y, Svensson L, Nordgren J. Predominance of norovirus and sapovirus in Nicaragua after implementation of universal rotavirus vaccination. PLoS ONE. 2014;9(5):e98201.PubMedPubMedCentralCrossRef
26.
Dove W, Cunliffe NA, Gondwe JS, Broadhead RL, Molyneux ME, Nakagomi O, Hart CA. Detection and characterization of human caliciviruses in hospitalized children with acute gastroenteritis in Blantyre, Malawi. J Med Virol. 2005;77(4):522–7.PubMedCrossRef
27.
Liu J, Kibiki G, Maro V, Maro A, Kumburu H, Swai N, Taniuchi M, Gratz J, Toney D, Kang G, Houpt E. Multiplex reverse transcription PCR Luminex assay for detection and quantitation of viral agents of gastroenteritis. J Clin Virol. 2011;50(4):308–13.PubMedPubMedCentralCrossRef
28.
Elfving K, Andersson M, Msellem MI, Welinder-Olsson C, Petzold M, Björkman A, Trollfors B, Mårtensson A, Lindh M. Real-time PCR threshold cycle cutoffs help to identify agents causing acute childhood diarrhea in Zanzibar. J Clin Microbiol. 2014;52(3):916–23.PubMedPubMedCentralCrossRef
29.
Lekana-Douki SE, Kombila-Koumavor C, Nkoghe D, Drosten C, Drexler JF, Leroy EM. Molecular epidemiology of enteric viruses and genotyping of rotavirus A, adenovirus and astrovirus among children under 5 years old in Gabon. Int J Infect Dis. 2015;34:90–5.PubMedCrossRef
30.
Matussek A, Dienus O, Djeneba O, Simpore J, Nitiema L, Nordgren J. Molecular characterization and genetic susceptibility of sapovirus in children with diarrhea in Burkina Faso. Infect Genet Evol. 2015;32:396–400.PubMedCrossRef
31.
Liu X, Yamamoto D, Saito M, Imagawa T, Ablola A, Tandoc AO III, Segubre-Mercado E, Lupisan SP, Okamoto M, Furuse Y, Saito M. Molecular detection and characterization of sapovirus in hospitalized children with acute gastroenteritis in the Philippines. J Clin Virol. 2015;68:83–8.PubMedCrossRef
32.
Liu X, Jahuira H, Gilman RH, Alva A, Cabrera L, Okamoto M, Xu H, Windle HJ, Kelleher D, Varela M, Verastegui M. Etiological role and repeated Infections of sapovirus among children aged less than 2 years in a cohort study in a peri-urban community of Peru. J Clin Microbiol. 2016;54(6):1598–604.PubMedPubMedCentralCrossRef
33.
Pongsuwanna Y, Tacharoenmuang R, Prapanpoj M, Sakon N, Komoto S, Guntapong R, Taniguchi K. Monthly distribution of norovirus and sapovirus causing viral gastroenteritis in Thailand. Jpn J Infect Dis. 2017;70(1):84–6.PubMedCrossRef
34.
35.
Grohmann GS, Glass RI, Pereira HG, Monroe SS, Hightower AW, Weber R, Bryan RT. Enteric viruses and diarrhea in HIV-infected patients. N Engl J Med. 1993;329(1):14–20.PubMedCrossRef
36.
Liste MB, Natera I, Suarez JA, Pujol FH, Liprandi F, Ludert JE. Enteric virus Infections and diarrhea in healthy and human immunodeficiency virus-infected children. J Clin Microbiol. 2000;38(8):2873–7.PubMedPubMedCentralCrossRef
37.
38.
Jarchow-Macdonald AA, Halley S, Chandler D, Gunson R, Shepherd SJ, Parcell BJ. First report of an astrovirus type 5 gastroenteritis outbreak in a residential elderly care home identified by sequencing. J Clin Virol. 2015;73:115–9.PubMedCrossRef
39.
40.
GBD 2016 Lower Respiratory Infections Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower Respiratory Infections in 195 countries, 1990–2016: a systematic analysis for the global burden of Disease Study 2016. Lancet Infect Dis. 2018;18(11):1191.CrossRef
41.
Ghebremedhin B. Human adenovirus: viral pathogen with increasing importance. Eur J Microbiol Immunol. 2014;4(1):26–33.CrossRef
42.
Ouédraogo N, Kaplon J, Bonkoungou IJ, Traoré AS, Pothier P, Barro N, Ambert-Balay K. Prevalence and genetic diversity of enteric viruses in children with diarrhea in Ouagadougou, Burkina Faso. PLoS ONE. 2016;11(4):e0153652.PubMedPubMedCentralCrossRef
43.
Reis TA, Assis AS, Valle DA, Barletta VH, Carvalho IP, Rose TL, Portes SA, Leite JP. The role of human adenoviruses type 41 in acute Diarrheal Disease in Minas Gerais after Rotavirus vaccination. Braz J Microbiol. 2016;47:243–50.PubMedPubMedCentralCrossRef
44.
45.
Blackwell CC, Gordon AE, James VS, MacKenzie DA, Mogensen-Buchanan M, El Ahmer OR, Al Madani OM, Törö K, Csukás Z, Sótonyi P, Weir DM, Busuttil A. The role of bacterial toxins in sudden infant death syndrome (SIDS). Int J Med Microbiol. 2002;291(6–7):561–70.PubMed
46.
Blood-Siegfried J, Rambaud C, Nyska A, Germolec DR. Evidence for Infection, inflammation and shock in sudden infant death: parallels between a neonatal rat model of sudden death and infants who died of sudden infant death syndrome. Innate Immun. 2008;14(3):145–52.PubMedCrossRef
47.
Weber MA, Klein NJ, Hartley JC, Lock PE, Malone M, Sebire NJ. Infection and sudden unexpected death in infancy: a systematic retrospective case review. Lancet. 2008;371(9627):1848–53.PubMedCrossRef
48.
Highet AR, Goldwater PN. Staphylococcal enterotoxin genes are common in Staphylococcus aureus intestinal flora in Sudden Infant Death Syndrome (SIDS) and live comparison infants. FEMS Immunol Med Microbiol. 2009;57(2):151–5.PubMedCrossRef
49.
Hoffman HJ, Damus K, Hillman L, Krongrad E. Risk factors for SIDS: results of the National Institute of Child Health and Human Development SIDS cooperative epidemiological study. Ann N Y Acad Sci. 1988;533:13–30.PubMedCrossRef
50.
Bányai K, Estes MK, Martella V, Parashar UD. Viral gastroenteritis. The Lancet. 2018;392(10142):175–86.CrossRef
51.
Ayukekbong J, Lindh M, Nenonen N, Tah F, Nkuo-Akenji T, Bergström T. Enteric viruses in healthy children in Cameroon: viral load and genotyping of norovirus strains. J Med Virol. 2011;83(12):2135–42.PubMedCrossRef
52.
Chitambar S, Gopalkrishna V, Chhabra P, Patil P, Verma H, Lahon A, Arora R, Tatte V, Ranshing S, Dhale G, Kolhapure R, Tikute S, Kulkarni J, Bhardwaj R, Akarte S, Pawar S. Diversity in the enteric viruses detected in outbreaks of gastroenteritis from Mumbai, Western India. Int J Environ Res Public Health. 2012;9(3):895–915.PubMedPubMedCentralCrossRef
53.
Arowolo KO, Ayolabi CI, Lapinski B, Santos JS, Raboni SM. Epidemiology of enteric viruses in children with gastroenteritis in Ogun State, Nigeria. J Med Virol. 2019;91(6):1022–9.PubMedCrossRef
54.
Flahault A, Hanslik T. Épidémiologie des gastroentérites virales en France et en Europe. Bull Acad Natl Med. 2010;194(8):1415–25.PubMed
55.
Biscaro V, Piccinelli G, Gargiulo F, Ianiro G, Caruso A, Caccuri F, De Francesco MA. Detection and molecular characterization of enteric viruses in children with acute gastroenteritis in Northern Italy. Infect Genet Evol. 2018;60:35–41.PubMedCrossRef
56.
Rossouw E, Brauer M, Meyer P, Du Plessis NM, Avenant T, Mans J. Virus etiology, diversity and clinical characteristics in South African children hospitalised with gastroenteritis. Viruses. 2021;13(2):215.PubMedPubMedCentralCrossRef
57.
58.
Chukwu MO, Abia AL, Ubomba-Jaswa E, Dewar JB, Obi CL. Mixed aetiology of Diarrhoea in infants attending clinics in the North-West Province of South Africa: potential for sub-optimal treatment. Pathogens. 2020;9(3):198.PubMedPubMedCentralCrossRef
59.
Operario DJ, Platts-Mills JA, Nadan S, Page N, Seheri M, Mphahlele J, Praharaj I, Kang G, Araujo IT, Leite JP, Cowley D. Etiology of severe acute watery diarrhea in children in the global rotavirus surveillance network using quantitative polymerase chain reaction. J Infect Dis. 2017;216(2):220–7.PubMedPubMedCentralCrossRef
60.
Patel MM, Widdowson MA, Glass RI, Akazawa K, Vinjé J, Parashar UD. Systematic literature review of role of noroviruses in sporadic gastroenteritis. Emerg Infect Dis. 2008;14(8):1224.PubMedPubMedCentralCrossRef
61.
Siebenga JJ, Vennema H, Zheng DP, Vinjé J, Lee BE, Pang XL, Ho EC, Lim W, Choudekar A, Broor S, Halperin T. Norovirus Illness is a global problem: emergence and spread of norovirus GII. 4 variants, 2001–2007. J Infect Dis. 2009;200(5):802–12.PubMedCrossRef
62.
Tran TH, Trainor E, Nakagomi T, Cunliffe NA, Nakagomi O. Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII. 4 variants. J Clin Virol. 2013;56(3):269–77.CrossRef
63.
64.
Ferreira MS, Victoria M, Carvalho-Costa FA, Vieira CB, Xavier MP, Fioretti JM, Andrade J, Volotão EM, Rocha M, Leite JP, Miagostovich MP. Surveillance of norovirus Infections in the state of Rio De Janeiro, Brazil 2005–2008. J Med Virol. 2010;82(8):1442–8.PubMedCrossRef
65.
McAtee CL, Webman R, Gilman RH, Mejia C, Bern C, Apaza S, Espetia S, Pajuelo M, Saito M, Challappa R, Soria R. Burden of norovirus and rotavirus in children after rotavirus vaccine introduction, Cochabamba, Bolivia. Am J Trop Med Hyg. 2016;94(1):212.PubMedPubMedCentralCrossRef
66.
Zou W, Cui D, Wang X, Guo H, Yao X, Jin M, Huang Q, Gao M, Wen X. Clinical characteristics and molecular epidemiology of noroviruses in outpatient children with acute gastroenteritis in Huzhou of China. PLoS ONE. 2015;10(5):e0127596.PubMedPubMedCentralCrossRef
67.
Govender N, Perovic O, Meiring S, Kleynhans J, von Gottberg A, Thomas J, Ismail F, Ismail N, Page NA, Hunt G. GERMS-SA Annual Report 2018. National Institute for Communicable Diseases. 2017:37 – 8.
68.
Gelaw A, Pietsch C, Liebert UG. Genetic diversity of human adenovirus and human astrovirus in children with acute gastroenteritis in Northwest Ethiopia. Arch Virol. 2019;164(12):2985–93.PubMedCrossRef
69.
Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR. Prevalence of classic, MLB-clade and VA-clade astroviruses in Kenya and the Gambia. Virol J. 2015;12(1):1–7.CrossRef
70.
Nadan S, Taylor MB, Groome MJ, Cohen C, Madhi SA, Page NA. Epidemiology of human astroviruses among children younger than 5 years: prospective hospital-based sentinel surveillance in South Africa, 2009‐2014. J Med Virol. 2019;91(2):225–34.PubMedCrossRef
71.
Hwang BM, Jung S, Jeong HJ, Chung GT, Kang YH, Yang SJ, Seo NY, Shin TH, Yoo CK, Lee DY. Outbreak of astrovirus in adults with acute gastroenteritis in Korea. J Gastrointest Dig Syst. 2015;13:1–4.
72.
Page N, Groome MJ, Murray T, Nadan S, Netshikweta R, Keddy KH, Poonsamy B, Moyes J, Walaza S, Kahn K, Kuonza L. Sapovirus prevalence in children less than five years of age hospitalised for diarrhoeal Disease in South Africa, 2009–2013. J Clin Virol. 2016;78:82–8.PubMedCrossRef
73.
Pang XL, Honma S, Nakata S, Vesikari T. Human caliciviruses in acute gastroenteritis of young children in the community. J Infect Dis. 2000;181(Supplement2):288–94.CrossRef
74.
Sakai Y, Nakata S, Honma S, Tatsumi M, Numata-Kinoshita K, Chiba S. Clinical severity of Norwalk virus and Sapporo virus gastroenteritis in children in Hokkaido, Japan. Pediatr Infect Dis J. 2001;20(9):849–53.PubMedCrossRef
75.
Kotloff KL, Nasrin D, Blackwelder WC, Wu Y, Farag T, Panchalingham S, Sow SO, Sur D, Zaidi AK, Faruque AS, Saha D. The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to the global enteric Multicenter Study (GEMS). Lancet Glob Health. 2019;7(5):e568–84.PubMedPubMedCentralCrossRef
76.
Mohammad HA, Madi NM, Al-Nakib W. Analysis of viral diversity in stool samples from infants and children with acute gastroenteritis in Kuwait using Metagenomics approach. Virol J. 2020;17(1):1–2.CrossRef
77.
Potgieter N, Heine L, Ngandu JPK, Ledwaba SE, Zitha T, Mudau LS, Becker P, Traore AN, Barnard TG. High Burden of Co-infection with multiple enteric pathogens in children suffering with Diarrhoea from Rural and Peri-urban communities in South Africa. Pathogens. 2023;12(2):315.PubMedPubMedCentralCrossRef
78.
Zhang M, Differding MK, Benjamin-Neelon SE, Østbye T, Hoyo C, Mueller NT. Association of prenatal antibiotics with measures of infant adiposity and the gut microbiome. Ann Clin Microbiol Antimicrob. 2019;18(1):18.PubMedPubMedCentralCrossRef
79.
Li L, Wang F, Liu Y, Gu F. Intestinal microbiota dysbiosis in children with recurrent respiratory tract Infections. Microb Pathog. 2019;136:103709.PubMedCrossRef
80.
Sabey KA, Song SJ, Jolles A, Knight R, Ezenwa VO. Coinfection and Infection duration shape how pathogens affect the African buffalo gut microbiota. ISME J. 2021;15(5):1359–71.PubMedCrossRef
81.
Mathew S, Smatti MK, Al Ansari K, Nasrallah GK, Al Thani AA, Yassine HM. Mixed viral-bacterial Infections and their effects on Gut Microbiota and Clinical illnesses in Children. Sci Rep. 2019;9(1):865.PubMedPubMedCentralCrossRef
82.
83.
Heimesaat MM, Boelke S, Fischer A, Haag LM, Loddenkemper C, Kühl AA, Göbel UB, Bereswill S. Comprehensive postmortem analyses of intestinal microbiota changes and bacterial translocation in human flora associated mice. PLoS ONE. 2012;7(7):e40758.PubMedPubMedCentralCrossRef
84.
Beal S, Porter C. Sudden infant death syndrome related to climate. Acta Paediatr Scand. 1991;80(3):278–87.PubMedCrossRef
85.
D’souza RM, Hall G, Becker NG. Climatic factors associated with hospitalizations for rotavirus Diarrhoea in children under 5 years of age. Epidemiol Infect. 2008;136(1):56–64.PubMedCrossRef
86.
Raza MW, Blackwell CC. Sudden infant death syndrome, virus Infections and cytokines. FEMS Immunol Med Microbiol. 1999;25(1–2):85–96.PubMedCrossRef
87.
Read JS, Clemens JD, Klebanoff MA. Moderate low birth weight and Infectious Disease mortality during infancy and childhood. Am J Epidemiol. 1994;140(8):721–33.PubMedCrossRef
88.
Bobak DA, Guerrant RL. Nausea, vomiting, and noninflammatory diarrhea. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 2015:1253–1262.
89.
Ponsonby AL, Dwyer T, Gibbons LE, Cochrane JA, Wang YG. Factors potentiating the risk of sudden infant death syndrome associated with the prone position. N Engl J Med. 1993;329(6):377–82.PubMedCrossRef
Metadata
Title
Screening for viral pathogens in the gastrointestinal tract from cases of sudden unexpected death in infancy at the Tygerberg Medico-legal Mortuary
Authors
Danielle T Cupido
Corena de Beer
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Adenovirus
Published in
Virology Journal / Issue 1/2023
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-023-02249-y

Other articles of this Issue 1/2023

Virology Journal 1/2023 Go to the issue

Research

ARIH1 inhibits influenza A virus replication and facilitates RIG-I dependent immune signaling by interacting with SQSTM1/p62

Research

Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019

Research

Prevalence and characteristics of HTLV-associated uveitis in patients from Bahia, an endemic area for HTLV − 1 in Brazil

Research

HIV transmission and associated factors under the scale-up of HIV antiretroviral therapy: a population-based longitudinal molecular network study

Research

SARS-CoV-2 infection aggravates cigarette smoke-exposed cell damage in primary human airway epithelia

Research

Detection of parechovirus A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients from Panama (2014–2015)
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits